Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population DOI Open Access
Alena Kalyakulina, Igor Yusipov, Elena Kondakova

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13741 - 13741

Опубликована: Дек. 23, 2024

Yakutia is one of the coldest permanently inhabited regions in world, characterized by a subarctic climate with average January temperatures near −40 °C and minimum below −60 °C. Recently, we demonstrated accelerated epigenetic aging Yakutian population comparison to their Central Russian counterparts, residing considerably milder climate. In this paper, analyzed these cohorts from inflammaging perspective addressed two hypotheses: mismatch immunological profiles inflammatory Yakuts. We found that levels 17 cytokines displayed statistically significant differences mean values between groups (with minimal p-value = 2.06 × 10−19), 6 them are among 10 SImAge markers. five out six markers (PDGFB, CD40LG, VEGFA, PDGFA, CXCL10) had higher cohort, therefore, due positive chronological age correlation, might indicate trend toward aging. At same time, biological acceleration difference according clock was not detected because they similar CXCL9, CCL22, IL6, top contributing biomarkers SImAge. introduced an explainable deep neural network separate individual groups, resulting over 95% accuracy. The obtained results allow for hypothesizing specificity cytokine chemokine people living extremely cold climates, possibly reflecting effects long-term human (dis)adaptation conditions related risk developing number pathologies.

Язык: Английский

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation DOI Creative Commons
Ioana Agache, Cezmi A. Akdiş, Mübeccel Akdiş

и другие.

Frontiers in Science, Год журнала: 2024, Номер 2

Опубликована: Апрель 4, 2024

Global warming and climate change have increased the pollen burden frequency intensity of wildfires, sand dust storms, thunderstorms, heatwaves—with concomitant increases in air pollution, heat stress, flooding. These environmental stressors alter human exposome trigger complex immune responses. In parallel, pollutants, allergens, other factors increase risks skin mucosal barrier disruption microbial dysbiosis, while a loss biodiversity reduced exposure to diversity impairs tolerogenic development. The resulting dysregulation is contributing an immune-mediated diseases such as asthma allergic diseases, autoimmune cancer. It now abundantly clear that multisectoral, multidisciplinary, transborder efforts based on Planetary Health One approaches (which consider dependence health environment natural ecosystems) are urgently needed adapt mitigate effects change. Key actions include reducing emissions improving quality (through fossil fuel use), providing safe housing (e.g., weatherization), diets (i.e., diversity) agricultural practices, increasing green spaces. There also pressing need for collaborative, multidisciplinary research better understand pathophysiology context New data science techniques, biomarkers, economic models should be used measure impact disease, inform mitigation adaptation efforts, evaluate their effectiveness. Justice, equity, diversity, inclusion (JEDI) considerations integral these address disparities

Язык: Английский

Процитировано

21
Skin Barrier in Atopic Dermatitis DOI
Matthias Schmuth,

Sonja Eckmann,

Verena Moosbrugger‐Martinz

и другие.

Journal of Investigative Dermatology, Год журнала: 2024, Номер 144(5), С. 989 - 1000.e1

Опубликована: Апрель 19, 2024

Язык: Английский

Процитировано

12
Impact of climate change and air pollution on childhood respiratory health DOI Creative Commons
Marilyn Urrutia‐Pereira, Dirceu Solé

Jornal de Pediatria, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

To assess the impact of climate change and air pollution on children's respiratory health. Narrative review articles published in English, Portuguese, French, Spanish last decade following databases: PubMed, Google Scholar, EMBASE, SciELO. The keywords used this search were: changes OR indoor pollutants wildfires AND human health children exposome. Increases extreme weather events, such as heat waves, forest fires, floods, droughts, hurricanes, dust storms, put system at greater risk. growing global increase diseases recent decades raises questions about environmental factors resulting from industrialization, urbanization, individual's Understanding it better is a key point for treatment.

Язык: Английский

Процитировано

0
Subacute thyroiditis – Is it really linked to viral infection? Retrospective hospital patient registry study DOI Creative Commons
Hans Martin Orth, Alexander Killer,

Smaranda Gliga

и другие.

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Objective Subacute thyroiditis (SAT) is a painful inflammatory disorder of the thyroid gland, which – after phase thyrotoxicosis leads to transient, or less frequently permanent hypothyroidism. Apart from strong association with specific HLA alleles, causes are uncertain. Viral disease has been hypothesised as trigger, Enteroviruses, namely Echoviruses and Coxsackieviruses, showing seasonal distribution that coincides incidence SAT. In first year COVID-19 pandemic, strict hygiene measures led sharp decline in infections thus offered opportunity test this hypothesis. Methods We analysed national registry data hospitalised patients Germany during years 2015 2022 (Federal statistical Office (Destatis), Wiesbaden, Germany) surveillance on infectious diseases same (clinical-virology.net RKI). Statistical analysis includes modelling seasonality by month, polynomial autoregression Granger causality assess dependency future SAT frequencies past ones, virus frequency, respectively. Results Our study confirms previously described epidemiological findings higher females peak late summer coinciding enteroviruses until 2019. 2020, pattern remained unchanged, except for marked reduction other pathogens (except SARS-CoV-2) due hygienic measures. Moreover, 2021 was apparently unaltered through pandemic. Conclusions provides evidence despite their pattern, Coxsackieviruses not cause no (including Influenza A B, Parainfluenza, Rhinovirus, Human Coronaviruses including showed any association.

Язык: Английский

Процитировано

0
Prenatal and Postnatal Ambient Air Pollution and Kawasaki Disease DOI
Penghui Yang, Jing Zhang, Kai‐Jun Zhang

и другие.

JACC Advances, Год журнала: 2025, Номер 4(4), С. 101651 - 101651

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease DOI Creative Commons
Pierluigi Rio, Mario Caldarelli, Antonio Gasbarrini

и другие.

Diseases, Год журнала: 2024, Номер 12(6), С. 118 - 118

Опубликована: Июнь 3, 2024

According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution

Язык: Английский

Процитировано

4
The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies DOI Creative Commons
Mary G. George,

Tonisha T. Gaitor,

David Cluck

и другие.

Therapeutic Advances in Infectious Disease, Год журнала: 2025, Номер 12

Опубликована: Янв. 1, 2025

Anthropogenic climate change, primarily driven by greenhouse gas emissions, is reshaping ecosystems and creating conditions that affect 58% of all known human infectious diseases, including fungal infections. Specifically, increasing temperatures, changing precipitation patterns, extreme weather events are influencing growth, distribution, virulence. These factors may expand the geographic range pathogenic fungi, exposing populations to novel, potentially more virulent, or drug-resistant strains. Simultaneously, such as declining immunity, aging populations, increased use immunosuppressive therapies enhancing host susceptibility. This review explores intricate relationship between change infections, highlighting pathogens demonstrate virulence antifungal resistance, along with emerging novel pathogens. The clinical implications profound, morbidity, mortality, spread infections into new regions. Immediate action required develop policies, educational initiatives, therapies, enhance early diagnostic capabilities, address healthcare disparities mitigate growing burden

Язык: Английский

Процитировано

0
Communication Disruption in the Immune System DOI

Robert Barouki,

Xavier Coumoul, Étienne Blanc

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Wildfire and Wood Smoke Effects on Human Airway Epithelial Cells: A Scoping Review DOI

Behzad Heibati,

Harald Renz, Paige Lacy

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 121153 - 121153

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Effects of temperature on daily hospital visits for urticaria in Nanchang, China: a distributed lag nonlinear time series analysis DOI
Jing Zhang, Fadong Zhang,

Weijun Liu

и другие.

International Journal of Environmental Health Research, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Март 26, 2025

This study evaluated temperature's lagged effects on urticaria outpatient visits in Nanchang, China (2017-2022), and identified sensitive populations through age/gender stratification. Using a distributed lag nonlinear model (DLNM), we analyzed 71,779 visits, adjusting for humidity, weekday, holidays, seasonal/long-term trends. Temperature (cold: 5th/25th percentiles; hot: 75th/95th percentiles) were compared to the 50th percentile. exhibited non-linear delayed impacts. Daily averages >19.9°C initially increased then decreased risk, peaking at 29°C with 15-day (RR=1.74, 95% CI:1.63-1.86). No adverse occurred below 19.9°C. Individuals aged ≥60 most vulnerable: 16-day lag, RR surged 2.31 (95% CI:1.99-2.70). Hot increases while cold reduces risk. These findings highlight temperature-specific prevention strategies, particularly older adults.

Язык: Английский

Процитировано

0