Biologics in severe asthma: a state-of-the-art review
European Respiratory Review,
Год журнала:
2025,
Номер
34(175), С. 240088 - 240088
Опубликована: Янв. 1, 2025
Asthma
is
considered
severe
if
it
remains
uncontrolled
despite
optimal
conventional
therapy,
characterised
by
poor
symptom
control,
frequent
exacerbations
and
increased
exposure
to
systemic
corticosteroids.
This
has
a
significant
impact
on
morbidity,
mortality
healthcare
resource
utilisation.
Recent
advances
in
the
understanding
of
asthma
heterogeneity
immunopathogenesis
have
helped
delineate
precise
disease
pathways.
The
discovery
these
pivotal
pathways
led
development
highly
effective
biologic
therapies.
Currently
available
biologics
target
immunoglobulin
E,
interleukin
(IL)-5/IL-5Rα,
IL-4Rα
thymic
stromal
lymphopoietin.
Identification
specific
phenotypes,
utilising
easily
measurable
biomarkers,
paved
way
towards
personalised
precision
management.
Biologic
therapies
play
role
reducing
exacerbations,
hospitalisations
need
for
maintenance
steroids,
while
also
improving
quality
life
patients
with
asthma.
evidence
their
clinical
efficacy
comes
from
randomised
controlled
trials
(RCTs),
extension
studies,
metanalyses
real-world
data.
review
synthesises
findings
early,
RCTs
subsequent
studies
following
approval
safety
data
completed
variety
settings,
provide
practical
perspectives
application
enhance
generalisability.
Язык: Английский
First-in-human study on tolerability, pharmacokinetics and pharmacodynamics of single and multiple escalating doses of XKH001, a recombinant humanized monoclonal antibody against IL-25 in healthy Chinese volunteers
Expert Opinion on Investigational Drugs,
Год журнала:
2025,
Номер
unknown, С. 1 - 7
Опубликована: Янв. 16, 2025
Background
XKH001
is
a
recombinant
humanized
IgG1
monoclonal
antibody
against
IL-25
for
the
treatment
of
type
2
inflammatory
diseases.
This
study
aimed
to
evaluate
tolerability,
pharmacokinetics,
and
pharmacodynamics
in
humans
first
time.
Язык: Английский
Different Phenotypes of Pediatric Asthma Show Distinct Bacterial Functional Profiles and Network Relationships
Allergies,
Год журнала:
2025,
Номер
5(2), С. 14 - 14
Опубликована: Май 6, 2025
Pediatric
asthma
is
the
most
common
chronic
childhood
disease
in
US
and
a
major
public
health
concern.
It
considered
to
comprise
multiple
clinical
variants
or
phenotypes
with
different
etiologies
pathophysiologies.
Former
research
has
shown
that
airway
bacteriomes
vary
composition
structure
across
pediatric
phenotypes,
but
their
functional
diversity
bacterial
interactions
have
hardly
been
investigated.
A
previous
study
of
163
children
from
Washington
DC
identified
three
statistically
each
unique
nasopharyngeal
diversity.
Here,
I
reanalyze
16S
rRNA
high-throughput
sequences
same
cohort
characterize
metabolism
interactions.
detect
61
102
metabolic
pathways
(PICRUSt2;
q
≤
0.05)
differentially
expressed
phenotypes.
Most
those
are
related
biosynthesis
degradation
processes
(p
0.0012)
separated
groups.
Co-occurrence
networks
also
differ
connectivity
suggesting
group.
Five
eight
keystone
taxa
detected
Insights
this
studies,
hence,
confirm
bacteriome
heterogeneity
asthma,
increasing
our
understanding
its
etiology
pathophysiology,
provide
new
taxonomic
biomarkers
for
targeted
interventions
therapies.
Язык: Английский
Oral Administration of Trichosanthes Kirilowii Fruit Extract Ameliorates Airway Inflammation and Suppresses Th2 Cell Activities in Ovalbumin‐Sensitized Mice
The Kaohsiung Journal of Medical Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 29, 2025
ABSTRACT
Trichosanthes
kirilowii
is
a
plant
used
in
traditional
Chinese
medicine.
Its
fruits,
seeds,
and
roots
can
all
be
medicinally.
The
fruit
of
T.
has
moistening
effect
on
the
lung
for
arresting
cough.
However,
there
no
scientific
research
to
prove
that
improve
asthma.
Herein,
we
evaluated
whether
extract
(TK)
could
reduce
airway
inflammation
hyperresponsiveness
(AHR)
murine
model
Female
BALB/c
mice
were
sensitized
with
ovalbumin
induce
asthma
treated
varying
oral
doses
TK
from
days
14
27
experiment.
Additionally,
IL‐4/TNF‐α‐stimulated
BEAS‐2B
cells
different
investigate
inflammatory
cytokine
chemokine
secretion.
treatment
significantly
mitigated
AHR,
eosinophil
infiltration,
lungs
asthmatic
mice.
It
also
alleviated
goblet
cell
hyperplasia
ROS
levels
while
modulating
Th2‐associated
bronchoalveolar
lavage
fluid.
Moreover,
effectively
proinflammatory
cytokine,
chemokine,
eotaxin
IL‐4
TNF‐α‐stimulated
cells.
Our
results
indicate
improved
symptoms
through
suppressed
Th2‐cell
activation,
which
inflammation,
oxidative
stress,
AHR.
Язык: Английский
Asthma in Pregnancy
Obstetrics and Gynecology,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 5, 2025
Asthma
affects
up
to
10%
of
pregnancies
and
confers
risk
both
mother
child.
Adverse
maternal
outcomes
associated
with
asthma
include
preeclampsia,
preterm
labor,
increased
cesarean
delivery.
Maternal
also
increases
risks
low
birth
weight
small-for-gestational-age
weight,
as
well
pediatric
respiratory
disease,
including
neonatal
distress
early-onset
asthma.
Despite
these
risks,
evidence
suggests
that
chronic
acute
exacerbations
remain
undertreated
in
pregnancy.
Recent
landmark
clinical
trials
nonpregnant
individuals
have
shown
that,
even
for
patients
mild
using
as-needed
inhaled
corticosteroids
combined
long-acting
bronchodilators
rescue
therapy
dramatically
reduces
exacerbations.
Inhaled
are
considered
safe
pregnancy
effective
reducing
symptoms,
preventing
exacerbations,
mitigating
some
adverse
outcomes.
Therefore,
should
be
included
a
mainstay
the
treatment
regimens
all
pregnant
women
asthma,
preferably
an
corticosteroid
rapid-onset
bronchodilator
combination
inhaler
use
daily
maintenance
those
more
persistent
symptoms
or
factors
complications.
Clinicians
actively
discourage
discontinuation
de-escalation
therapies
during
educate
on
safety
importance
medications
themselves
their
offspring.
confer
additional
risk,
so
they
must
promptly
recognized
treated
systemic
bronchodilators.
This
Clinical
Expert
Series
article
provides
overview
pregnancy,
focus
its
potential
health
effects
core
principles
evaluation
Язык: Английский
Different Allergen-Induced Asthma and Anaphylaxis Show Distinctive IgE Pathway Dependence
Allergy medicine.,
Год журнала:
2024,
Номер
2, С. 100010 - 100010
Опубликована: Сен. 19, 2024
Язык: Английский
Multifaceted roles of mitochondria in asthma
Cell Biology and Toxicology,
Год журнала:
2024,
Номер
40(1)
Опубликована: Окт. 9, 2024
Mitochondria
are
essential
organelles
within
cells,
playing
various
roles
in
numerous
cellular
processes,
including
differentiation,
growth,
apoptosis,
energy
conversion,
metabolism,
and
immunity.
The
phenotypic
variation
of
mitochondria
is
specific
to
different
tissues
cell
types,
resulting
significant
differences
their
function,
morphology,
molecular
characteristics.
Asthma
a
chronic,
complex,
heterogeneous
airway
disease
influenced
by
external
factors
such
as
environmental
pollutants
allergen
exposure,
well
internal
at
the
tissue,
cellular,
genetic
levels,
lung
structural
immune
granulocytes,
mast
cells.
Therefore,
comprehensive
understanding
responses
stimuli
changes
crucial
for
elucidating
pathogenesis
asthma.
Previous
research
on
mitochondrial-targeted
therapy
asthma
has
primarily
focused
antioxidants.
Consequently,
it
necessary
summarize
multifaceted
discover
additional
strategies
targeting
this
context.
In
review,
our
goal
describe
mitochondrial
function
response
exposure
across
types
other
relevant
context
asthma,
utilizing
new
terminology
framework
that
encompasses
cell-dependent
characteristics,
features,
activity,
behavior.
Язык: Английский
Asma e interação gene-ambiente: estamos no caminho certo em nossa prática clínica?
Revista Brasileira de Saúde Materno Infantil,
Год журнала:
2024,
Номер
24
Опубликована: Янв. 1, 2024
Asthma and gene-environment interaction: are we on the right path in our clinical practice?
Revista Brasileira de Saúde Materno Infantil,
Год журнала:
2024,
Номер
24
Опубликована: Янв. 1, 2024
Язык: Английский
Diversity and Meta-Analysis of Microbial Differential Abundance in Nasal Metatranscriptomic Profiles of Asthma
Deleted Journal,
Год журнала:
2024,
Номер
1(4), С. 10018 - 10018
Опубликована: Янв. 1, 2024
Asthma
affects
millions
worldwide
and
involves
complex
genetic,
immunological,
environmental
factors.
The
nasal
microbiome
is
increasingly
recognized
for
its
role
in
asthma
development,
but
inconsistent
results
small
sample
sizes
have
limited
a
clear
understanding.
We
aimed
to
clarify
the
microbiome's
using
large
datasets
meta-transcriptomic
analysis.
RNA-seq
data
was
analyzed
from
two
public
studies:
GALA
II
(694
children
of
Puerto
Rican
heritage;
441
asthmatics,
253
controls)
CAAPA
(562
individuals
African
ancestry;
265
297
controls).
After
quality
control
host
read
removal,
microbial
reads
were
annotated
Kraken2.
α
β
diversity
analyses
compared
between
asthmatic
groups.
Differential
abundance
analysis
conducted
separately,
controlling
age
sex,
with
combined
via
meta-analysis.
found
that
patients
exhibited
significantly
higher
indices
(Shannon,
Berger-Parker,
Inverse
Simpson,
Fisher's)
microbiota
controls
II,
similar
trends
CAAPA.
showed
significant
differences
composition
data.
identified
20
species
9
associated
asthma.
Meta-analysis
revealed
11
asthma,
including
Язык: Английский