The Effects and Mechanisms of Exercise on the Treatment of Depression

Frontiers in Psychiatry, Год журнала: 2021, Номер 12

Опубликована: Ноя. 5, 2021

Background: It is necessary to seek alternative therapies for depression, because side effects of medications lead poor adherence and some patients do not achieve a clinical treatment effect. Recently the role exercise as low-cost easy-to-use depression has gained attention with number studies showing that effective at reducing depressive symptoms improving body functions such cardiorespiratory system cognitive function. Because heterogeneity therapy programs, there no standardized unified program. Few have summarized specific properties programs (type, intensity, duration, frequency) prescriptions are mentioned in most articles. Aims: This study aimed investigate feasibility efficacy order appraise evidence outline accepted guidelines direct individualized plans based on their individual situations. Methods: A systematic review English language literature including papers published from 2010 present PubMed was performed. Given prescribing nearly 3 years treatments were first reviewed, comparing utilized. Conclusions: Exercise therapeutic all age groups (mostly 18-65 old), single therapy, an adjuvant or combination benefits comparable traditional depression. Moderate intensity enough reduce symptoms, but higher-dose better overall functioning. become more widely used its cardiovascular system, emotional state, systemic functions. Recommendations: Aerobic exercise/mind-body (3-5 sessions per week moderate lasting 4-16 weeks) recommended. Individualized protocols form group supervision increasing treatment.

Язык: Английский

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Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes

Frontiers in Psychiatry, Год журнала: 2019, Номер 9

Опубликована: Янв. 9, 2019

Major depression shortens life while the effectiveness of frontline treatments remains modest. Exercise has been shown to be effective both in reducing mortality and treating symptoms major depression, but it is still underutilized clinical practice, possibly due prevalent misperceptions. For instance, a common misperception that exercise beneficial for mostly because its positive effects on body ("from neck down"), whereas core features up") underappreciated. Other long-held misperceptions are patients suffering from will not engage even if physicians prescribe it, only vigorous effective. Lastly, false assumption may more harmful than old age, therefore should recommended younger patients. This narrative review summarizes relevant literature address aforementioned provide practical recommendations prescribing individuals with depression.

Язык: Английский

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Molecular mechanisms of physical exercise on depression in the elderly: a systematic review

Molecular Biology Reports, Год журнала: 2021, Номер 48(4), С. 3853 - 3862

Опубликована: Апрель 1, 2021

Язык: Английский

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Understanding Vulnerability to Late-Life Suicide

Current Psychiatry Reports, Год журнала: 2021, Номер 23(9)

Опубликована: Июль 17, 2021

Язык: Английский

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Physical Activity and Depression in Adolescents: Evidence from China Family Panel Studies

Behavioral Sciences, Год журнала: 2022, Номер 12(3), С. 71 - 71

Опубликована: Март 8, 2022

Depression in adolescents is a major public health disorder. The relationship between physical activity and risk of depression was examined using three waves data from the China Family Panel Studies 2020. significantly higher among who reported lower frequency shorter duration exercise than those more frequently for longer duration. intense little or no exercise. amount time spent on housework by inversely associated with depression. These results provide somewhat stronger evidence an activity−depression link previous studies suggest differential role different types activity, such as housework. overall model predicting (LR chi-squared = 95.974, p < 0.001, Nagelkerke R-square 0.183) statistically significant. To effectively control adolescents, government, schools parents need to act together guide towards participation appropriate activities. level experience breathing, rapid heartbeat, slight perspiration.

Язык: Английский

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Treatment resistant late-life depression: A narrative review of psychosocial risk factors, non-pharmacological interventions, and the role of clinical phenotyping

Journal of Affective Disorders, Год журнала: 2024, Номер 356, С. 145 - 154

Опубликована: Апрель 7, 2024

Язык: Английский

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The relationship between demoralization and depressive symptoms among patients from the general hospital: network and exploratory graph analysis

Journal of Affective Disorders, Год журнала: 2020, Номер 276, С. 137 - 146

Опубликована: Июль 14, 2020

Язык: Английский

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Antidepressant Drugs and Physical Activity: A Possible Synergism in the Treatment of Major Depression?

Frontiers in Psychology, Год журнала: 2020, Номер 11

Опубликована: Май 6, 2020

Major depressive disorder (MDD) is a severe mental illness that affects 5 to 20% of the general population. Current antidepressant drugs exerts only partial clinical efficacy because approximately 30% depressed patients failed respond these and antidepressants produce remission in patients. This can be explained by fact complex pathophysiology depression has not been completely elucidated, treatments have mainly developed following "monoaminergic hypothesis" without considering key role other factors involved pathogenesis MDD, such as chronic stress neuroinflammation. Chronic acts risk factor for development MDD through impairment neurotrophins signaling brain-derived neurotrophic (BDNF) transforming-growth-factor-β1 (TGF-β1). Stress-induced pathology contributes altered BDNF level function and, thereby, an neuroplasticity at regional circuit level. Recent studies demonstrate aerobic exercise strongly increases production it may contribute non-pharmacological strategy improve treatment cognitive affective symptoms MDD. Here we will provide overview on possible synergism between physical activity Physical synergize with rescuing neurotrophin patients, promoting neuronal health recovery MDD-related circuits, finally enhancing pharmacotherapeutic response. might particularly relevant elderly late-life depression, subgroup increased develop dementia.

Язык: Английский

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Primary prevention of depression: An umbrella review of controlled interventions

Journal of Affective Disorders, Год журнала: 2021, Номер 294, С. 957 - 970

Опубликована: Июль 31, 2021

Язык: Английский

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Physical Activity as a Clinical Tool against Depression: Opportunities and Challenges

Journal of Integrative Neuroscience, Год журнала: 2022, Номер 21(5), С. 132 - 132

Опубликована: Июль 22, 2022

Depression is a major public health issue in numerous countries, with around 300 million people worldwide suffering from it. Typically, depressed patients are treated antidepressants or psychological therapy combination of both. However, there some limitations associated these therapies and as result, over the past decades number alternative complementary have been developed. Exercise one such option that supported by published extensive basic clinical research data. The aim this review was to examine beneficial effects exercise depression. Physical activity shown be effective treating mild-to-moderate depression reducing mortality symptoms physical still underused practice. This attempts propose framework help clinicians their decision-making process, how incorporate toolkit potential therapeutic responses for patients. We first summarize interactions between activities, particular focus on antidepressant physiological activity. then identify barriers blocking being used fight Finally, we present several perspectives ideas can optimizing mitigation strategies challenge barriers, including actions representations, ways increase accessibility activity, technology both

Язык: Английский

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