The Antidepressant Potential of <i>Heracleum persicum</i> Essential Oil in the Forced Swim Test in Mice: Involvement of Antioxidant and Monoaminergic Mechanisms

Journal of Reports in Pharmaceutical Sciences, Год журнала: 2025, Номер 13(1)

Опубликована: Май 14, 2025

Background: Previous studies have highlighted the significant role of oxidative stress in depression. Conversely, Heracleum persicum has demonstrated notable antioxidant properties. However, no study been conducted to explore antidepressant effects H. essential oil (HPEO) and its mechanisms action. Objectives: This investigates potential HPEO a forced swim test (FST). Methods: In this study, mice (22 - 28 g) were administered (125 500 mg/kg, i.p.) one hour before performing FST. Additionally, mouse serum levels glutathione (GSH), catalase (CAT), nitric oxide (NO) measured. To assess monoaminergic system mechanism action oil, various receptor antagonists (500 mg/kg). Results: The mg/kg) increased CAT GSH decreased NO levels. Acute administration (250 reduced immobility FST without significantly altering animals' locomotion open field (OFT). Pretreatment with sulpiride, haloperidol, SCH23390, yohimbine, prazosin, p-chlorophenylalanine (pCPA), WAY100135, ketanserin, reserpine restrained HPEO. Conclusions: For first time, research demonstrates HPEO, which appears be mediated by dopaminergic, serotonergic, noradrenergic systems, as well

Язык: Английский

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Actual Data on Essential Trace Elements in Parkinson’s Disease

Nutrients, Год журнала: 2025, Номер 17(11), С. 1852 - 1852

Опубликована: Май 29, 2025

“Sola dosis facit venenum” (Paracelsus). Essential trace elements, crucial for maintaining neuronal function, have their dysregulation increasingly correlated with neurodegenerative disorders, particularly Parkinson’s disease (PD). This systematic review aims to synthesize recent high-quality evidence regarding the involvement of essential such as iron, zinc, copper, manganese, and selenium, in pathogenesis and, consequently, potential therapeutic targets PD. A comprehensive literature search was conducted articles published between 1 January 2023 31 December 2024. Out an initial pool 1231 identified studies, 63 met methodological eligibility criteria according PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines. All potentially eligible interventional observational studies were initially assessed using Physiotherapy Evidence Database (PEDro) scale, which is commonly employed evaluating internal validity statistical interpretability clinical trials rehabilitation-focused studies. Following qualitative assessment PEDro 18 ultimately selected based on scientific relevance rigor. To supplement scoring, designed primarily individual trials, we applied AMSTAR-2 (A MeaSurement Tool Assess Reviews) checklist evaluation included reviews or meta-analyses. The a variety clinical, postmortem, experimental models investigate trace-element concentrations mechanistic roles findings revealed consistent patterns iron accumulation substantia nigra, zinc’s bidirectional effects oxidative stress autophagy, copper-induced α-synuclein aggregation, neuroprotective role selenium via antioxidant pathways. Manganese associated mitochondrial dysfunction neuroinflammation. disturbances contribute PD pathology through interconnected mechanisms involving redox imbalance, protein misfolding, impaired cellular homeostasis. These elements may serve both biomarkers tools, warranting further investigation into personalized metal-based interventions

Язык: Английский

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Association between dietary selenium intake and depression in patients with or without stroke: a cross-sectional study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Июнь 5, 2025

Background Depression and stroke are life-threatening diseases with high incidence, research suggests an interaction between dietary selenium depression stroke. However, the relationship has not been adequately studied. Therefore, purpose of this study was to assess association among individuals or without Methods A cross-sectional performed using 2011–2018 National Health Nutrition Examination Survey dataset ( N = 15,018). Logistic regression, effect analysis, restricted cubic spline analysis were used for statistical analyses. Results The intake prevalence differed non-stroke groups. Furthermore, when converted into a categorical variable, there evidence status on decreasing p 0.007). What’s more, dose–response indicated various patterns participants Limitations cannot be infer causal relationships. Conclusion non-linear observed in stroke, characterized by apparent threshold approximately 128.4 mcg/d. In contrast, no Further is necessary validate present findings.

Язык: Английский

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Next-generation analytical platforms for antioxidant capacity assessment: The urge for realistic and physiologically relevant methods

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115155 - 115155

Опубликована: Июль 14, 2023

Bioactive compounds, such as carotenoids, alkaloids, and phenolics, are well known because of their alleged health benefits when consumed regularly in a balanced healthy diet. Some well-documented bioactivities antioxidant, antihypertensive, antihyperglycemic, antilipidemic, anti-obesity, anti-inflammatory, antimicrobial capacities. Trying to associate the chemical composition distinct sources bioactivity using vitro methods, several assays have been developed, implemented, optimised recapitulate human physiological conditions. However, most cases, pitfalls apparent, no single test tube-based assay can predict vivo responses. The need for more physiologically relevant cell-based method evaluate antioxidant capacity putative antioxidants is apparent. Therefore, this Review, current state-of-the-art food science nutrition aligned with cell biology/bioengineering approaches propose combining digestion absorption obtain bioavailable fraction containing antioxidants. Overall, plasma, 2-dimensional lines, erythrocytes, lymphocytes, hepatocytes, enterocytes and, ultimately, 3-dimensional spheroids (organoids) could be used biologically models assess activity foods, nutraceuticals. This versatile approach deemed suitable, accurate, reproducible, protective effects against ROS-mediated oxidation vitro.

Язык: Английский

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Protein-enriched and anti-inflammatory dietary patterns, healthy lifestyle index and depressive symptoms: A cross-sectional study of 287,945 adults in China

Journal of Affective Disorders, Год журнала: 2024, Номер 351, С. 863 - 869

Опубликована: Фев. 9, 2024

Язык: Английский

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