Monoclonal antibody precision therapy targeting inflammation for bipolar disorder: a narrative review

Therapeutic Advances in Psychopharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 1, 2024

Bipolar disorder (BD) is a severe mental with various hypotheses regarding its pathogenesis. This article provides summary of numerous studies on the variations in inflammatory cytokine levels patients BD and effects treatment antipsychotics, mood stabilizers, antidepressants these levels. In addition, autoimmune diseases who use anti-inflammatory monoclonal antibodies experience symptoms, such as depression, anxiety, insomnia. These pieces evidence suggest potential association between immune inflammation offer new possibilities for therapy. Building upon this relationship, authors propose an innovative approach treating through individualized precise therapy using antibody drugs. To support proposal, compile information pharmacological relevant studies, including trials therapeutic drugs (e.g. infliximab, tocilizumab, canakinumab) associated side psychiatry. The categorize into I–IV comprehensive analysis their advantages disadvantages. Their examined, need further exploration pharmaceutical established.

Язык: Английский

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Pathophysiological Mechanisms of Psychosis-Induced Atrial Fibrillation: The Links between Mental Disorder and Arrhythmia

Reviews in Cardiovascular Medicine, Год журнала: 2024, Номер 25(9)

Опубликована: Сен. 24, 2024

Atrial fibrillation (AF) is a common phenomenon of sustained arrhythmia leading to heart failure or stroke. Patients with mental disorders (MD), particularly schizophrenia and bipolar disorder, are at high risk AF triggered by the dysregulation autonomic nervous system, atrial stretch, oxidative stress, inflammation, electrical structural remodeling. Moreover, pathophysiological mechanisms underlying MD may also contribute genesis AF. An overactivated hypothalamic–pituitary–adrenal axis, aberrant renin–angiotensin–aldosterone abnormal serotonin signaling, disturbed sleep, genetic/epigenetic factors can adversely alter electrophysiology substrates, development In this review, we provide an update our collective knowledge molecular that link Targeting pathogenic MD-specific facilitate therapeutics mitigate cardiovascular mortality in patient population.

Язык: Английский

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T-cell immunophenotype correlations with cortical thickness and white matter microstructure in bipolar disorder

Journal of Affective Disorders, Год журнала: 2023, Номер 348, С. 179 - 190

Опубликована: Дек. 26, 2023

Inflammation and immunological alterations, such as T-cell cytokine changes, are implicated in bipolar disorder (BD), with some evidence linking them to brain structural changes (e.g., cortical thickness (CT), gray matter (GM) volume white (WM) microstructure). However, the connection between specific peripheral cell types, T-cells, neuroimaging BD remains scarcely investigated.

Язык: Английский

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Peripheral inflammation is associated with impaired sadness recognition in euthymic bipolar patients

Journal of Psychiatric Research, Год журнала: 2024, Номер 173, С. 333 - 339

Опубликована: Март 28, 2024

Язык: Английский

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Climate Change and Psychiatry: Correlation between Mean Monthly Temperature and Admissions to an Acute Inpatient Unit

Опубликована: Май 9, 2024

Background: Many clinical conditions are affected by meteorological factors and climate changes. Psychiatric disorders large contributors to the global disease burden, but literature on impact of changes mental health is limited. The aim this study investigate correlation between rising temperatures admissions for acute exacerbations psychiatric disorders. Methods: Data were collected summer months years 2013 2022. Mean monthly tempera-tures obtained from station Department Physics Universi-ty Turin. patients admitted unit San Luigi Gonzaga Univer-sity Hospital (Turin, Italy) extracted hospital registry. Linear regression analyses used temperature number admissions. Results: A total 1600 our ward recorded. temper-ature directly correlated (P = 0.0020). was significant subgroup due Bipo-lar Disorders (BD) (P=0.0011), not Schizophrenia (P=0.6070) (SCZ) or Major Depressive Disorder (MDD) (P=0.0588). Conclusions: These results confirm disorders, in particular course BD. This provides new insights into etiopathological mechanisms can contribute improved follow up relapse prevention.

Язык: Английский

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Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2024, Номер 9(9), С. 896 - 904

Опубликована: Май 28, 2024

Язык: Английский

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Climate Change and Psychiatry: The Correlation between the Mean Monthly Temperature and Admissions to an Acute Inpatient Unit

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(7), С. 826 - 826

Опубликована: Июнь 25, 2024

Background: Psychiatric disorders are large contributors to the global disease burden, but research on impact of climate change them is limited. Our aim investigate correlation between temperature and exacerbations psychiatric help inform clinical management future public health policies. Methods: Temperature records for summer months from 2013 2022 were obtained meteorological station Department Physics Turin University. Data patients admitted acute unit extracted registries San Luigi Gonzaga University Hospital (Turin, Italy). Regression analyses used number admissions test confounding variables. Results: A total 1600 recorded. The monthly directly correlated (p = 0.0020). was significant subgroup due Bipolar Disorders 0.0011), not schizophrenia or major depressive disorder. After multiple regression analyses, effect remained 0.0406). Conclusions: These results confirm factors mental disorders, particularly BD. This can contribute personalised follow-up efficient resource allocation poses grounds studies into etiopathological mechanisms therapeutic implications.

Язык: Английский

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Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Опубликована: Апрель 18, 2023

Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.

Язык: Английский

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Resting-state functional magnetic resonance imaging in bipolar affective disorder. A systematized umbrella review

V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, Год журнала: 2023, Номер 57(3), С. 15 - 29

Опубликована: Июль 19, 2023

Bipolar affective disorder (BD) is a complex mental illness that presents diagnostic challenges due to its heterogeneous nature. As result, identifying potential markers for the crucial effective diagnosis and treatment. Resting-state functional magnetic resonance imaging (rs-fMRI) promising non-invasive technique provides window into pathophysiological characteristics of psychiatric neurological diseases in vivo. The amount data accumulated scientific community regarding changes spontaneous activity connectivity brain regions BD necessitates comprehensive synthesis determine spectrum disorders. Accordingly, systematic review reviews was conducted summarize characteristic patients with as measured by fMRI. Qualitative results nine six meta-analyses has allowed definition most BD, confirming unity disturbances this nosological unit. findings indicate manic state often associated increased amygdala decreased between frontal regions. Conversely, depressive phase characterized abnormalities within default mode network, particularly relation posterior cingulate cortex. Changes during periods euthymia may reflect residual manifestations one exacerbation phases or be history psychotic episode. Furthermore, comparative analysis possible methods quantitative fMRI been first time Russia, which valuable contribution field.

Язык: Английский

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Effects of Exercise on Functional Recovery in Patients with Bipolar Depression: A Study Protocol for a Randomized Controlled Trial

Metabolites, Год журнала: 2023, Номер 13(9), С. 981 - 981

Опубликована: Авг. 30, 2023

Treatment of bipolar disorder is prone to prolongation despite various treatments, including medication. The efficacy exercise treatment (i.e., interventions involving physical and sports intervention) for major depressive disorders has been reported symptoms, cognitive function, sleep disturbances. However, its yet be established. We designed a randomized, controlled, double-blind clinical trial that includes 100 patients with aged 20–65 years. This will cluster-randomized, two-group conducted in ten psychiatric hospitals. hospitals randomly assigned an intervention + as usual (exercise) group or placebo (stretching) (control) group. Patients assessed using extensive battery tests, parameters, status, biological parameters (cytokines, neurotrophic factors), genetic (DNA RNA) at baseline after 6-week period, 10-week follow-up, 6-month follow-up. innovative study may provide important evidence the effectiveness depression based on clinical, biological, genetic, physiological markers.

Язык: Английский

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