Annual Research Review: Puberty and the development of anhedonia – considering childhood adversity and inflammation

Journal of Child Psychology and Psychiatry, Год журнала: 2024, Номер 65(4), С. 459 - 480

Опубликована: Фев. 23, 2024

Anhedonia, or diminished pleasure and motivation, is a symptom of severe mental illness (e.g., depressive disorder, bipolar schizophrenia) that emerges during adolescence. Anhedonia pernicious related to social impairments, treatment resistance, suicide. As the mechanisms anhedonia are postulated include frontostriatal circuitry dopamine neuromodulatory system, development plasticity these systems vulnerable period adolescence, as well their sensitivity pubertal hormones, suggest maturation could play role in anhedonia. This review takes developmental perspective, considering possibility context adolescent development, with childhood adversity chronic inflammation influencing neural reward accelerate anhedonia's progression. Here, we relevant extant literature on components this model directions for future research.

Язык: Английский

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The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Июнь 28, 2023

Depression is generally accompanied by a disturbed conscious processing of emotion, which manifests as negative bias to facial/voice emotion information and decreased accuracy in recognition tasks. Several studies have proved that abnormal brain activation was responsible for the deficit function depression. However, altered related depression incongruent among studies. Therefore, we conducted an likelihood estimation (ALE) analysis better understand underlying neurophysiological mechanism depression.Electronic databases were searched using search terms "depression," "emotion recognition," "neuroimaging" from inceptions April 10th, 2023. We retrieved trials explored neuro-responses depressive patients explicit Two investigators independently performed literature selection, data extraction, risk assessment. The spatial consistency facial expressions calculated ALE. robustness results examined Jackknife sensitivity analysis.We 11,365 articles total, 28 included. In overall analysis, found increased activity middle temporal gyrus, superior parahippocampal cuneus, inferior parietal lobule, insula, frontal gyrus. response positive stimuli, showed hyperactivity medial insula (uncorrected p < 0.001). When receiving higher precentral precuneus, gyrus 0.001).Among patients, broad spectrum areas involved processing. regions different or stimuli. Due potential clinical heterogeneity, findings should be treated with caution.https://inplasy.com/inplasy-2022-11-0057/, identifier: 2022110057.

Язык: Английский

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Effects of Pollution Burden on Neural Function During Implicit Emotion Regulation and Longitudinal Changes in Depressive Symptoms in Adolescents

Biological Psychiatry Global Open Science, Год журнала: 2024, Номер 4(4), С. 100322 - 100322

Опубликована: Апрель 26, 2024

Exposure to environmental pollutants early in life has been associated with increased prevalence and severity of depression adolescents; the neurobiological mechanisms underlying this association are not well understood. In current longitudinal study, we investigated whether pollution burden adolescence (9-13 years) is altered brain activation connectivity during implicit emotion regulation changes depressive symptoms across adolescence. 145 participants (N=87 females; 9-13 provided residential addresses, from which determined their relative at census-tract level, performed an affective task scanner. Participants also completed questionnaires assessing three timepoints, each approximately two years apart, calculated within-person slopes symptoms. We conducted whole-brain analyses examine alterations function positively- negatively-valenced stimuli, how these effects related Greater was greater bilateral medial prefrontal cortex (MPFC) stronger MPFC regions within default mode network (DMN; e.g., temporoparietal junction, posterior cingulate cortex, precuneus) negative emotions, increases those exposed higher burden. Adolescents living communities characterized by showed DMN functioning emotions that

Язык: Английский

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Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors

Journal of Mood and Anxiety Disorders, Год журнала: 2025, Номер unknown, С. 100116 - 100116

Опубликована: Март 1, 2025

Язык: Английский

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