Mendelian randomisation studies for causal inference in chronic obstructive pulmonary disease: A narrative review
Pulmonology,
Год журнала:
2025,
Номер
31(1)
Опубликована: Фев. 25, 2025
Background
and
objective
Most
non-randomised
controlled
trials
are
unable
to
establish
clear
causal
relationships
in
chronic
obstructive
pulmonary
disease
(COPD)
due
the
presence
of
confounding
factors.
This
review
summarises
evidence
that
Mendelian
randomisation
method
can
be
a
powerful
tool
for
performing
inferences
COPD.
Язык: Английский
Assessing Causality Between Plasma Brain‐Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study
Brain and Behavior,
Год журнала:
2025,
Номер
15(3)
Опубликована: Март 1, 2025
ABSTRACT
Purpose
This
study
employed
a
two‐sample
Mendelian
randomization
(MR)
approach
to
investigate
the
bidirectional
relationship
between
brain‐derived
neurotrophic
factor
(BDNF)
and
major
depressive
disorder
(MDD),
addressing
gaps
left
by
prior
observational
studies.
Methods
We
utilized
Genome‐Wide
Association
Study
(GWAS)
datasets,
including
MDD
information
from
Psychiatric
Genomics
Consortium
(PGC)
UK
Biobank
(
N
=
500,199),
along
with
plasma
BDNF
measurements
FinnGen
619).
In
subsequent
phase,
we
analyzed
data
448,069)
three
additional
GWAS
sources:
33,924),
deCODE
35,353),
INTERVAL
3301).
Multiple
MR
methods
were
applied
ensure
robust
analysis.
Results
The
inverse
variance
weighted
(IVW)
method
revealed
no
significant
association
levels
risk
of
developing
(IVW
odds
ratio
[OR]
1.00,
95%
confidence
interval
[CI]
0.99–1.01,
p
0.769).
Similarly,
causal
effect
gene
on
was
identified
(OR
0.91,
CI
0.23–3.56,
0.893).
Furthermore,
there
evidence
supporting
link
0.99,
0.89–1.09,
0.783).
second
phase
analysis
confirmed
absence
relationships.
Conclusion
provides
MDD.
These
findings
prompt
re‐evaluation
as
biomarker
for
emphasize
need
further
investigation
into
its
functional
role
within
well
activity
in
brain
cerebrospinal
fluid.
Язык: Английский
Trajectories of depressive symptoms and the risk of cardiovascular, dementia, and pulmonary events in older adults: Evidence from the English Longitudinal Study of Ageing
General Hospital Psychiatry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Genetic evidence supporting causality between atopic dermatitis and chronic obstructive pulmonary disease
International Immunopharmacology,
Год журнала:
2025,
Номер
155, С. 114602 - 114602
Опубликована: Апрель 11, 2025
Язык: Английский
Causal effects of Hirschsprung's disease on psychiatric disorders in the European population: a two-sample Mendelian randomization study
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Background:
Previous
studies
have
suggested
a
potential
association
between
Hirschsprung's
disease
(HSCR)
and
psychiatric
disorders.
However,
the
causal
relationship
HSCR
disorders
remains
unclear.
Therefore,
we
use
Mendelian
randomization
to
explore
depression,
anxiety,
attention
deficit
hyperactivity
disorder(ADHD),
autism
spectrum
disorder(ASD).
Methods:
Genome-wide
Studies
(GWAS)
meta-analyses
with
largest
possible
sample
size
independent
individuals
from
European
ancestry
were
selected.
The
genetic
data
for
depression
anxiety
are
FinnGen
consortium,
while
ADHD
ASD
Psychiatric
Genomics
Consortium.
Inverse
variance
weighted
(IVW)
was
main
analysis
method.
heterogeneity
of
instrumental
variables
(IVs)
assessed
using
IVW
MR-Egger,
horizontal
pleiotropy
IVs
MR-Egger
MR-PRESSO.
Results:
revealed
significant
ADHD(OR=1.010，95%CI=1.002-1.018；P=0.0119).
there
is
no
evidence
suggest
ASD.
Furthermore,
our
sensitivity
did
not
reveal
any
or
pleiotropy.
Conclusion:
Our
results
that
increases
risk
ADHD.
greater
should
be
paid
psychological
health
children
HSCR.
Язык: Английский
Potential value of B7-H3 in sepsis diagnosis and prognosis: A Mendelian randomization study.
PubMed,
Год журнала:
2024,
Номер
49(11), С. 1790 - 1798
Опубликована: Ноя. 28, 2024
Sepsis
remains
a
major
global
health
challenge,
yet
specific
diagnostic
biomarkers
are
still
lacking.
This
study
aims
to
investigate
the
causal
relationship
between
B7
homologue
3
(B7-H3)
and
sepsis
susceptibility,
severity,
clinical
outcomes
using
Mendelian
randomization
(MR)
analysis,
in
order
evaluate
its
potential
as
biomarker.
Genetic
data
related
(including
overall
sepsis,
sepsis-related
mortality
with
28
days,
severe
28-day
mortality)
were
extracted
from
genome-wide
association
(GWAS)
datasets.
Single
nucleotide
polymorphisms
(SNPs)
associated
B7-H3
selected
instrumental
variables.
The
inverse-variance
weighted
(IVW)
was
used
primary
approach
for
effect
estimation,
while
median
(WME)
MR-Egger
regression
served
supplementary
methods.
Additionally,
constrained
maximum
likelihood-model
average
(cML-MA)
employed
enhance
reliability
of
estimation.
Cochran's
Q
test
conducted
assess
heterogeneity,
MR-PRESSO
along
intercept
method
detect
horizontal
pleiotropy.
Sensitivity
analyses
performed
leave-one-out
method.
A
reverse
MR
analysis
exposure
outcome
exclude
causation.
IVW
indicated
significant
positive
outcomes.
genetically
predicted
1-standard
deviation
(SD)
increase
levels
10.4%
increased
risk
(OR=1.104,
95%
CI
1.021
1.194,
P=0.013),
26.2%
(OR=1.262,
1.078
1.476,
P=0.004),
22.3%
(OR=1.223,
1.023
1.463,
P=0.027),
60.2%
(OR=1.602,
1.119
2.294,
P=0.010).
direction
remained
consistent
across
IVW,
WME,
MR-Egger,
cML-MA
analyses,
reinforcing
robustness
results.
showed
no
heterogeneity
(P>0.05),
tests
evidence
pleiotropy
(both
P>0.05).
that
removing
individual
SNPs
did
not
significantly
alter
estimates.
Reverse
B7-H3.
may
serve
an
important
biomarker
it
is
closely
Язык: Английский