Journal of Affective Disorders, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Июнь 12, 2024
Abstract Background Previous studies have shown a correlation between depression and obesity, as well the Atherogenic Index of Plasma (AIP). However, there is limited research on association visceral obesity depression, potential mediating role AIP in this relationship. Methods This study included 13,123 participants from 2005–2018 National Health Nutrition Examination Survey. Visceral was measured with Body Roundness (BRI), while evaluated Patient Questionnaire-9. The served marker for lipid disorders. To investigate BRI multivariate logistic regressions, restricted cubic spline models, subgroup analyses, interaction tests were used. Additionally, mediation analysis conducted to explore effect depression. Results There positive linear After controlling all covariates, individuals highest (Q4) group had an OR 1.42 (95% CI: 1.12–1.82) comparison lowest (Q1) group. Moreover, partially mediated accounting approximately 8.64% 2.04-16.00%) total effect. Conclusion positively associated playing role. provides novel perspective mechanism that connects Managing fat monitoring levels may contribute alleviating
Язык: Английский
Процитировано
8
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 30, 2025
Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated association between the atherogenic index plasma (AIP) and insulin resistance, there remains a scarcity large cohort investigating AIP long-term T2D in general population. This study aims to investigate potential individuals normal fasting glucose levels. retrospective included 15,453 participants. The was calculated using formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed assess risk. nonlinear examined restricted cubic spline (RCS) model. During average follow-up period 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated independently developing (HR 1.763, 95%CI 1.210–2.568, P = 0.003). RCS analysis revealed J-shaped risk, sharp increase when levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic consistently moderate predictability new-onset within 1 12 years. exhibits Therefore, maintaining below certain threshold (-0.268) might help prevent onset
Язык: Английский
Процитировано
1
European journal of psychotraumatology, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 13, 2025
Background: Depression is a prevalent mental disorder with high morbidity and mortality globally. Methylmalonic acid (MMA) involved in the pathogenesis of numerous diseases. However, it unclear whether there an association between MMA prevalence depression.
Язык: Английский
Процитировано
1
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Апрель 25, 2025
Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker dyslipidemia. However, whether AIP can be used as indicator aging remains unclear. This study aims investigate the relationship between US adult population. 4,471 American adults with age over 20 years National Health Nutrition Examination Survey (NHANES) database were included this study. Biological was assessed by phenotypic acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses interaction tests employed explore association PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) assess potential nonlinear relationships, while mediation analysis utilized identify mediating effects homeostatic model assessment insulin resistance (HOMA-IR). Besides, network pharmacology performed determine mechanisms underlying dyslipidemia-related acceleration. A total participants study, median chronological age, PhenoAge PhenoAgeAccel for overall population 49 (35-64) years, 42.85 (27.30-59.68) - 6.92 (- 10.52 -2.46) respectively. In fully model, one unit increase correlated 1.820-year (β = 1.820, 95% CI: 1.085-2.556), which more pronounced among individuals being female, diabetic hypertensive. RCS revealed PhenoAgeAccel, inflection point identified at -0.043 via threshold saturation effect analysis. demonstrated positive correlation both before 6.550, 5.070-8.030) after 3.898, 2.474-5.322) point. Additionally, HOMA-IR found mediate 39.21% Finally, INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, SERPINE1 core targets aging, functionally linked key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. CONCLUSIONS: An elevated notably positively accelerated suggesting that may serve predictor evaluate
Язык: Английский
Процитировано
1
Journal of Affective Disorders, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 16
Опубликована: Июнь 3, 2025
Background The atherogenic index of plasma (AIP) has been implicated in various disease processes, yet its relationship with depression, particularly the context differing glucose metabolism status, remains underexplored. This study aimed to investigate association between AIP and depression middle-aged older adults varying profiles. Methods Data were derived from China Health Retirement Longitudinal Study (CHARLS) conducted 2011 2018, encompassing 7,723 participants aged 45 years above. Depression was defined using a cutoff score ≥12 on 10-item Center for Epidemiologic Studies Scale (CESD-10). primary outcome interest incident depression. Logistic regression restricted cubic spline (RCS) models applied assess baseline levels risk across distinct categories. Results Elevated strongly associated increased odds In fully adjusted models, graded observed, higher quartiles corresponding greater risk. Participants highest quartile (Q4) had significantly (odds ratio [OR]: 3.36, 95% confidence interval [CI]: 2.67-4.24, P < 0.001) compared those lowest (Q1). Furthermore, RCS analyses revealed significant positive among individuals prediabetes mellitus (Pre-DM) diabetes (DM) (P 0.001), whereas no such found normal regulation (NGR) = 0.086). These findings suggest that status modifies Conclusion Higher are an adults, effects modulated by status. results highlight potential utility as biomarker metabolic health should be considered development targeted strategies prevention intervention.
Язык: Английский
Процитировано
0
Journal of Affective Disorders, Год журнала: 2024, Номер 369, С. 25 - 26
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
2
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Ноя. 8, 2024
Cardiovascular diseases (CVD), chronic kidney disease (CKD), and lipids are positively correlated with the presence of depressive symptoms. However, investigation into complex link that exists between cardiorenal syndrome (CRS) lipid indices depression remains scarce.
Язык: Английский
Процитировано
1
Journal of Affective Disorders, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1