Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 25, 2025

Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker dyslipidemia. However, whether AIP can be used as indicator aging remains unclear. This study aims investigate the relationship between US adult population. 4,471 American adults with age over 20 years National Health Nutrition Examination Survey (NHANES) database were included this study. Biological was assessed by phenotypic acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses interaction tests employed explore association PhenoAgeAccel. Furthermore, adjusted restricted cubic spline (RCS) assess potential nonlinear relationships, while mediation analysis utilized identify mediating effects homeostatic model assessment insulin resistance (HOMA-IR). Besides, network pharmacology performed determine mechanisms underlying dyslipidemia-related acceleration. A total participants study, median chronological age, PhenoAge PhenoAgeAccel for overall population 49 (35-64) years, 42.85 (27.30-59.68) - 6.92 (- 10.52 -2.46) respectively. In fully model, one unit increase correlated 1.820-year (β = 1.820, 95% CI: 1.085-2.556), which more pronounced among individuals being female, diabetic hypertensive. RCS revealed PhenoAgeAccel, inflection point identified at -0.043 via threshold saturation effect analysis. demonstrated positive correlation both before 6.550, 5.070-8.030) after 3.898, 2.474-5.322) point. Additionally, HOMA-IR found mediate 39.21% Finally, INS, APOE, APOB, IL6, IL10, PPARG, MTOR, ACE, PPARGC1A, SERPINE1 core targets aging, functionally linked key signaling pathways like AMPK, apelin, JAK-STAT, FoxO, etc. CONCLUSIONS: An elevated notably positively accelerated suggesting that may serve predictor evaluate

Язык: Английский

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Efficient analysis of the toxicity and mechanisms of Hexaconazole and two other triazole fungicides: insights from integrated network toxicology, molecular docking and bioinformatics data

Genome Instability & Disease, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Язык: Английский

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Dietary riboflavin (vitamin B2) intake and osteoporosis in U.S. female adults: unveiling of association and exploration of potential molecular mechanisms

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 7, 2025

Abstract Background Osteoporosis characterized by deteriorating bone loss is becoming one of the serious health problems globally. Vitamin B2, also known as riboflavin, exhibiting multiple prominent physiological traits such antioxidant effects, reducing lipid peroxidation and regulating glutathione redox cycle, allows it to be a potential agent improve loss. However, relationship between dietary vitamin B2 intake osteoporosis remains unelucidated. The objective this study was explore association in U.S. female adults using National Health Nutrition Examination Survey (NHANES) database. Methods Female participants with complete information on intake, dual-energy X-ray absorptiometry, other essential covariates from NHANES database were included current study. Multivariable logistic regression linear analyses conducted assess relationships mineral density (BMD) levels, respectively. Subgroup analyses, interaction tests, restricted cubic spline (RCS) further used verify stability, robustness nonlinearity association. Mediation analysis performed probe role serum alkaline phosphatase (ALP) aforementioned relationship, network pharmacology determine pathways key targets for health. Results A total 4, 241 four cycles After multivariate adjustment, beneficially associated reduced risk femur (OR Q4 vs. Q1 =0.613; 95%CI: 0.454–0.829). higher (quartile 4) significantly correlated decreased femoral BMD β being 0.020 (95%CI: 0.007–0.033), 0.015 0.002–0.027), 0.009–0.031) 0.022 0.006–0.037) femur, neck, trochanter, intertrochanter, respectively (all P value < 0.05). Covariate MET found modify (P = 0.0364), more pronounced subgroup insufficiently active individuals. Furthermore, RCS revealed that positively linearly OP increased levels trochanter while nonlinearly level neck. Additionally, mediated ALP, mediation proportion 12.43%, 7.58%, 12.17%, 7.64%, 6.99% OP, intertrochanter BMD, Finally, indicated mainly through like HIF-1 signaling pathway, longevity p53 etc. Conclusions Higher risks may represent modifiable lifestyle factor prevention management osteoporosis.

Язык: Английский

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Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling

Frontiers in Molecular Biosciences, Год журнала: 2025, Номер 12

Опубликована: Май 16, 2025

Glioblastoma (GBM) is a highly aggressive brain tumor and relatively common among malignant tumors in adults. Its rapid proliferation significant invasiveness make its treatment one of the major challenges research. Panaxadiol, compound extracted from ginseng roots, has been found to have therapeutic effects on various types tumors. Nonetheless, precise function underlying mechanisms this factor GBM yet be thoroughly investigated. In current study, we employed network pharmacology explore potential interactions Panaxadiol within framework GBM. Subsequently, confirmed efficacy via biological experiments aimed at elucidating through which it exerts anti-GBM effects. We collected relevant targets differential genes multiple databases. The analysis revealed 66 context Enrichment indicated that these might several key signaling pathways, including calcium, cAMP, cGMP-PKG pathways. Therefore, may exert by regulating calcium ions. Further, our MOCDE CytoHubba plugins Cytoscape identify seven hub genes, GRIA2, GRIN1, GRIN2B, GRM1, GRM5, HTR1A, HTR2A, validated their binding capabilities with molecular docking. Furthermore, conducted vitro vivo experiments, encompassed CCK-8, colony formation, flow cytometry apoptosis, intracellular ion measurement, xenograft utilizing nude mice, validate suppressing growth modulation levels. This study not only but also inhibitory release experiments.

Язык: Английский

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Integration of network pharmacology, metabolomics and lipidomics for clarifying the role of sphingolipid metabolism in the treatment of liver cancer by regorafenib

Life Sciences, Год журнала: 2024, Номер 358, С. 123165 - 123165

Опубликована: Окт. 22, 2024

Язык: Английский

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