Depression and Anxiety Disorders
Опубликована: Апрель 10, 2025
Abstract
Depression
(major
depressive
disorder)
is
widely
recognised
as
a
major
public
health
problem
around
the
world.
The
mainstay
of
treatment
prescription
antidepressants,
although
psychological
treatments
have
place
first‐line
alternative
to
antidepressants
in
milder
and
moderate
forms
depression.
This
chapter
concentrates
on
use
offers
advice
drug
choice,
dosing,
switching
strategies
sequencing
treatments.
near
exclusion
other
non‐drug
modalities
does
not
imply
any
lack
confidence
their
efficacy
but
simply
reflects
need
(in
prescribing
guideline)
concentrate
medicines‐related
subjects.
Antidepressants
are
number
anxiety
spectrum
disorders.
Use
selective
serotonin
reuptake
inhibitors
(SSRIs)
preoperative
period
has
been
associated
with
20%
increase
inpatient
mortality,
patient
factors
rather
than
could
be
excluded
cause.
Язык: Английский
Safety of Edaravone in real-world use: analysis based on FDA adverse event reporting system
Expert Opinion on Drug Safety,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Edaravone
is
a
novel
free
radical
scavenger
utilized
to
treat
amyotrophic
lateral
sclerosis
(ALS).
However,
long-term
safety
data
remain
limited.
Adverse
event
reports
related
edaravone
from
the
second
quarter
of
2017
2024
were
extracted
US
Food
and
Drug
Administration
(FDA)
Event
Reporting
System
database
(FAERS).
Disproportionality
analysis
was
conducted
utilizing
reporting
odds
ratio
(ROR),
proportional
(PRR),
Bayesian
confidence
propagation
neural
network
(BCPNN),
multi-item
gamma
Poisson
shrinker
(MGPS)
algorithms.
A
total
3,149
adverse
analyzed.
The
most
common
reactions
included
systemic
disorders
administration
site
reactions,
nervous
system
disorders,
respiratory
surgical
medical
procedures.
New
reaction
signals
disseminated
intravascular
coagulation,
gastric
fistula,
sputum
retention,
excessive
salivation,
fractures,
elevated
cystatin
C.
median
onset
time
for
events
43
days
(interquartile
range:
7-173
days).
This
study
confirmed
previously
reported
identified
several
new
ones
associated
with
edaravone.
These
findings
provide
valuable
insights
optimizing
ALS
patient
management
highlight
need
further
research
into
mechanisms
these
reactions.
Язык: Английский
Examining the Long-Term Impacts of Psychotropic Drugs and Considerations for People Discontinuing Treatment
Issues in Mental Health Nursing,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Март 21, 2025
Psychotropic
drugs
dominate
the
mental
healthcare
landscape.
This
is
despite
contention
over
their
proposed
mechanism
of
action,
concerns
for
adverse
effects,
and
questionable
effectiveness,
especially
long
term.
Mental
health
nurses
are
routinely
involved
in
administering
psychotropic
drugs,
observing
managing
providing
information
support
to
people
prescribed
these
agents.
critique
explores
current
understanding
action
evidence
effect
burden
implications
term
use.
The
role
deprescribing
supporting
discontinue
treatment
considered.
Язык: Английский
Effects of age, sex, daily dose, comorbidity and co‐medication on venlafaxine‐associated cardiovascular adverse events: A pharmacovigilance analysis of the FDA Adverse Event Reporting System database
British Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Abstract
Aims
This
study
aimed
to
provide
a
comprehensive
view
of
cardiovascular
adverse
events
(AEs)
associated
with
venlafaxine
(VEN)
therapy.
Methods
Cardiovascular
AE
reports
for
patients
receiving
VEN
therapy
were
retrieved
from
January
2004
December
2023
the
FDA
Adverse
Event
Reporting
System
database.
Effects
age,
sex
and
daily
dose
on
occurrence
different
types
AEs
influence
demographics,
dose,
comorbidity
co‐medication
death
in
analysed
by
multivariate
logistic
regression
analysis.
Results
The
included
16
110
following
treatment
(median
age:
51
years,
females:
69.78%,
median
dose:
100
mg/day).
was
increased
risks
cardiac
arrhythmias,
embolic
thrombotic
events,
torsade
de
pointes/QT
prolongation,
ischaemic
heart
disease,
failure,
cardiomyopathy
overall
events.
elderly
(≥
75
years),
male
sex,
(infections
infestations,
disorders,
nervous
system
disorders)
(quetiapine
clozapine)
related
VEN‐associated
AEs;
however,
risk
did
not
increase
regular
doses.
Conclusions
Our
confirmed
association
revealed
influencing
factors
VEN‐related
due
these
Based
obtained
evidence,
health
late‐elderly
complex
polytherapy
should
be
closely
monitored
when
they
receive
As
an
exploratory
study,
prospective
studies
are
needed
validate
our
findings
future.
Язык: Английский