Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders DOI Creative Commons
Ke Xiao, Xiuli Chang, Chenfei Ye

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Growing evidence suggests abnormalities of brain structural connectome in psychiatric disorders, but the causal relationships remain underexplored. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to investigate links between 206 white-matter connectivity phenotypes (n = 26,333, UK Biobank) and 13 major disorders 14,307 1,222,882). Forward MR identified effects genetically predicted five on six with associations being significant or suggestive. For instance, left-hemisphere frontoparietal control network right-hemisphere default mode was significantly negatively associated autism spectrum disorder risk, while increased hippocampus linked decreased anorexia nervosa cannabis use risk. Reverse revealed suggestively risk two four different phenotypes. example, susceptibility found be visual pallidum. These findings offer new insights into etiology highlight potential biomarkers for early detection prevention at level.

Язык: Английский

Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders DOI Creative Commons
Ke Xiao, Xiuli Chang, Chenfei Ye

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Growing evidence suggests abnormalities of brain structural connectome in psychiatric disorders, but the causal relationships remain underexplored. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to investigate links between 206 white-matter connectivity phenotypes (n = 26,333, UK Biobank) and 13 major disorders 14,307 1,222,882). Forward MR identified effects genetically predicted five on six with associations being significant or suggestive. For instance, left-hemisphere frontoparietal control network right-hemisphere default mode was significantly negatively associated autism spectrum disorder risk, while increased hippocampus linked decreased anorexia nervosa cannabis use risk. Reverse revealed suggestively risk two four different phenotypes. example, susceptibility found be visual pallidum. These findings offer new insights into etiology highlight potential biomarkers for early detection prevention at level.

Язык: Английский

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