Current Opinion in Pediatrics,
Год журнала:
2023,
Номер
35(6), С. 656 - 662
Опубликована: Авг. 31, 2023
As
the
incidence
of
allergic
conditions
has
increased
in
recent
decades,
effects
climate
change
have
been
implicated.
There
is
also
knowledge
on
other
physical
influences,
such
as
scratching
and
Staphylococcus
aureus
.
The
skin
barrier
first
line
defense
to
external
environment,
so
understanding
ways
that
these
factors
influence
dysfunction
important.Although
impact
environmental
exposures
well
studied
asthma
disorders,
there
now
more
literature
temperature,
air
pollution,
detergents
barrier.
Factors
cause
include
extreme
temperatures,
pollution
(including
greenhouse
gases
particulate
matter),
wildfire
smoke,
pollen,
scratching,
S.
aureus,
detergents.Understanding
insults
affect
important
further
understand
mechanisms
order
inform
medical
community
treatment
prevention
measures
for
atopic
conditions.
Postgraduate Medical Journal,
Год журнала:
2024,
Номер
100(1187), С. 649 - 656
Опубликована: Апрель 2, 2024
Abstract
Background
The
pathogenesis
of
atopic
dermatitis
(AD)
remains
unclear.
Nontyphoidal
Salmonella
(NTS)
infection
might
trigger
immune-mediated
reactions.
We
aimed
to
examine
NTS
and
the
risk
subsequent
AD.
Methods
From
2002
2015,
eligible
patients
(aged
0–100
years)
with
were
identified.
non-NTS
groups
matched
at
a
1:10
ratio
on
age
sex.
utilized
conditional
multivariable
Cox
proportional
hazard
models
estimate
adjusted
(aHR)
95%
confidence
interval
(CI)
for
AD
development.
Subgroup
analyses
conducted
based
age,
sex,
severity
infection.
landmark
analysis
explore
time-dependent
following
NTS.
Results
In
group
(N
=
6624),
403
developed
After
full
adjustment
demographics
comorbidities,
had
higher
than
reference
(aHR
1.217,
CI
1.096–1.352).
Age-stratified
revealed
that
exhibited
an
elevated
compared
group,
particularly
among
those
aged
13–30
years
1.25,
1.017–1.559),
individuals
31–50
1.388,
1.112–1.733),
51–70
1.301,
1.008–1.679),
71
over
1.791,
1.260–2.545).
Severe
was
associated
2.411,
1.577–3.685).
Landmark
showed
generally
consistent
findings.
Conclusions
Minimizing
exposure
may
represent
prospective
strategy
averting
onset
progression
dermatitis.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 29, 2024
Introduction
The
effects
of
fructo-oligosaccharides
(FOS)
on
atopic
dermatitis
(AD)
have
not
been
determined.
Methods
In
a
randomized,
double-blind,
placebo-controlled
trial,
children
with
AD
aged
24
months
to
17
years
received
either
advanced
FOS
containing
4.25
g
1-kestose
or
placebo
(maltose)
for
12
weeks.
Results
SCORAD
and
itching
scores
were
reduced
in
patients
treated
both
(all
p
<
0.01)
maltose
(
0.05
0.01).
Sleep
disturbance
was
improved
only
the
group
revealed
decreased
proportion
linoleic
acid
(18:2)
esterified
omega-hydroxy-ceramides
(EOS-CERs)
amide-linked
shorter
chain
fatty
acids
(C28
C30,
all
0.05),
along
an
increased
EOS-CERs
longer
(C32,
Discussion
may
be
beneficial
alleviating
sleep
disturbance,
as
well
improving
skin
barrier
function
AD.
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 9071 - 9085
Опубликована: Ноя. 1, 2024
The
nasal
mucosal
epithelial
barrier
is
the
primary
site
of
allergic
rhinitis
(AR).
Interleukin-1β
(IL-1β),
as
a
crucial
factor
in
immune
inflammation,
not
only
plays
role
hypersensitivity
reactions
but
also
affects
digestive
mucosa
and
skin
barrier.
However,
IL-1β
AR
has
been
reported,
this
study
aimed
to
investigate
effect
possible
mechanisms
involved.
Current Opinion in Pediatrics,
Год журнала:
2023,
Номер
35(6), С. 656 - 662
Опубликована: Авг. 31, 2023
As
the
incidence
of
allergic
conditions
has
increased
in
recent
decades,
effects
climate
change
have
been
implicated.
There
is
also
knowledge
on
other
physical
influences,
such
as
scratching
and
Staphylococcus
aureus
.
The
skin
barrier
first
line
defense
to
external
environment,
so
understanding
ways
that
these
factors
influence
dysfunction
important.Although
impact
environmental
exposures
well
studied
asthma
disorders,
there
now
more
literature
temperature,
air
pollution,
detergents
barrier.
Factors
cause
include
extreme
temperatures,
pollution
(including
greenhouse
gases
particulate
matter),
wildfire
smoke,
pollen,
scratching,
S.
aureus,
detergents.Understanding
insults
affect
important
further
understand
mechanisms
order
inform
medical
community
treatment
prevention
measures
for
atopic
conditions.
