La
esofagitis
eosinofílica
es
una
infiltración
del
esófago
por
eosinófilos,
presumiblemente
de
origen
alérgico,
que
se
presenta
en
niños
y
adultos.
En
estos
últimos
más
frecuente
hombres
edad
media
su
característica
clínica
principal
la
disfagia.
El
conocimiento
esta
enfermedad
ha
tenido
gran
desarrollo
los
10
años
con
mejor
entendimiento
fisiopatología
estudios
buscan
evaluar
diferentes
alternativas
tratamiento.
Se
revisión
literatura
describen
epidemiología,
manifestaciones
clínicas,
fisiopatología,
diagnóstico
diferencial
opciones
terapéuticas
enfermedad.
Current Opinion in Allergy and Clinical Immunology,
Год журнала:
2024,
Номер
24(3), С. 122 - 128
Опубликована: Апрель 24, 2024
Purpose
of
review
Eosinophilic
esophagitis
is
a
chronic
and
commonly
evolving
condition
leading
to
relevant
potentially
irreversible
burden
in
terms
tissue
damage
related
functional
impairment,
thus
significantly
impacting
on
quality
life.
The
aim
the
present
summarize
recent
advances
diagnostic
work-up
pharmacological
nonpharmacological
management
disease,
under
broader
perspective
type
2
inflammation.
Recent
findings
Two
major
novelties
have
prompted
an
innovative
approach
EoE.
In
diagnosis,
it
has
been
proposed
dissect
disease
heterogeneity
three
endotypes,
independent
from
eosinophil
number:
EoEe1,
characterized
by
normal
appearing
oesophagus;
EoEe2,
associated
with
inflammation
steroid-refractoriness;
EoEe3,
whose
features
include
adult
onset,
more
fibro-stenotic
aspect
loss
epithelial
gene
expression.
Concerning
treatment,
two
recently
licensed
drugs
for
EoE,
oro-dispersible
budesonide
dupilumab
represent
first
treatment
options
specifically
developed
EoE
addressing
EoE-related
peculiar
pathobiological
features.
Summary
era
precision
medicine,
managing
according
phenotype-driven
might
be
helpful
defining
best
different
forms
or
stages.
addition,
exploring
coexistence
previous
occurrence
other
conditions
may
suggest
opportunity
target
through
biologic
therapy.
complex
pathobiology
combining
inflammatory
features,
both
at
organ
systemic
level,
requires
multidimensional
relying
strict
integration
gastroenterologists
allergist-immunologists.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 22, 2024
Eosinophilic
esophagitis
(EoE)
is
a
chronic,
inflammatory,
antigen-driven
disease
of
the
esophagus.
Tissue
EoE
pathology
has
previously
been
extensively
characterized
by
novel
transcriptomics
and
proteomic
platforms,
however
majority
surface
marker
determination
screening
performed
in
blood
due
to
mucosal
tissue
size
limitations.
While
eosinophils,
CD4+
T
cells,
mast
cells
natural
killer
(NK)
were
investigated
context
EoE,
an
accurate
picture
composition
peripheral
mononuclear
(PBMC)
their
activation
missing.
In
this
study,
we
aimed
comprehensively
analyze
using
measurements
with
multicolor
flow
cytometry
simultaneously
both
patients
active
inactive
gastroesophageal
reflux
(GERD)
controls.
Moreover,
set
out
validate
our
data
co-cultures
PBMC
human
primary
esophageal
epithelial
inducible
mouse
model
eosinophilic
esophagitis,
extensive
IL-33
secretion
Our
results
indicate
that
specific
populations
are
enriched,
they
alter
expression
markers
EoE.
particular,
observed
upregulation
immunomodulatory
molecule
CD38
on
myeloid
biopsies
significant
PD-1
which
was
even
more
prominent
after
corticosteroid
treatment.
With
co-culture
experiments
could
demonstrate
direct
cell
contact
needed
for
cells.
Finally,
validated
findings
Herein
show
alterations
profile
comparison
GERD
controls,
have
potential
implications
To
knowledge,
study
first
its
kind
expanding
multi-color
approach
different
patient
groups
vitro
vivo
translational
models.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 5, 2024
Objectives
The
aim
of
the
study
was
to
characterize
circulating
immunome
patients
with
EoE
before
and
after
proton
pump
inhibitor
(PPI)
treatment
in
order
identify
potential
non-invasive
biomarkers
response.
Methods
PBMCs
from
19
healthy
controls
24
were
studied
using
a
39-plex
spectral
cytometry
panel.
plasmacytoid
dendritic
cell
(pDC)
population
differentially
characterized
by
analysis
immunofluorescence
assays
esophageal
biopsies
7
13
patients.
Results
Interestingly,
at
baseline
had
lower
levels
pDC
compared
controls.
Before
treatment,
who
responded
PPI
therapy
higher
classical
monocytes,
non-responders.
Moreover,
following
increased
all
patients,
while
normal
only
restored
PPI-responding
Finally,
inversely
correlated
peak
eosinophil
count
biopsies.
number
tissue
pDCs
significantly
during
active
EoE,
being
even
non-responder
when
responder
pre-PPI.
decreased
intake,
further
almost
control
post-PPI.
Conclusions
We
hereby
describe
unique
immune
fingerprint
diagnosis.
may
be
also
used
as
novel
biomarker
predict
subsequent
response
treatment.
Journal of Clinical Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 15, 2024
Goals:
We
assessed
satisfaction
with
and
adherence
to
off-label
corticosteroids
in
patients
eosinophilic
esophagitis
(EoE)
the
United
States.
Background:
EoE
is
a
chronic
inflammatory
disease
for
which
there
are
currently
no
US
Food
Drug
Administration-approved
swallowed
topical
corticosteroids.
Study:
This
noninterventional,
cross-sectional,
web-based
survey
included
caregivers
of
adolescents
(aged
11
17
y)
adults
18
years
or
older)
self-reported
[or
caregiver-reported
(adolescents)]
physician
diagnosis
who
were
receiving
Participants
recruited
through
2
nonprofit,
patient
advocacy
groups.
The
9-item
Treatment
Satisfaction
Questionnaire
Medication
(TSQM-9)
was
used
assess
across
effectiveness,
convenience,
global
domains
(scale:
1
100
per
domain);
higher
scores
indicated
greater
satisfaction.
4-item
Morisky
Green
Levine
Adherence
Scale
(MGL-4)
adherence;
an
MGL-4
score
<3
adherence.
also
reported
reasons
nonadherence.
Results:
Overall,
201
participants
(caregivers
adolescents,
n=98;
adults,
n=103)
this
study.
Mean
TSQM-9
low
all
3
(≤61.1)
(≤55.7).
Slightly
fewer
(37.1%)
than
(40.8%)
considered
adherent.
Forgetfulness
most
frequently
reason
nonadherence;
some
chose
not
take
their
medications,
owing
poor
palatability
(adolescents),
difficulty
taking
medications
at
specific
times
(adults),
feeling
depressed/overwhelmed
(adolescents
adults).
Conclusions:
Journal of Pediatric Gastroenterology and Nutrition,
Год журнала:
2024,
Номер
79(3), С. 550 - 557
Опубликована: Авг. 1, 2024
Pathology
is
an
essential
component
of
disease
diagnosis
and
management
in
pediatric
gastroenterology.
reports
have
not
been
standardized
some
areas
gastrointestinal
pathology
reporting
varies.
Development
electronic
medical
record
(EMR)
synoptic
report
templates
(PSRT)
enables
data
collection
a
specific
format
can
help
standardize
reporting.
We
developed,
implemented,
evaluated
EMR
PSRTs
for
eosinophilic
esophagitis
(EoE)
inflammatory
bowel
(IBD).
Revista JRG de Estudos Acadêmicos,
Год журнала:
2024,
Номер
7(14), С. e141190 - e141190
Опубликована: Июнь 7, 2024
Uma
condição
recentemente
identificada
que
incorpora
este
conceito
é
a
Esofagite
Eosinofílica
(EE).
Esta
afecção
caracterizada
por
inflamação
de
longa
duração
do
esôfago,
marcada
um
grande
número
eosinófilos
na
mucosa
proximal
e
distal.
Isto
pode
ou
não
ser
acompanhado
refluxo
gastroesofágico.
Desta
forma,
seguinte
pesquisa
tem
objetivo
compreender
sintetizar
informações
desde
os
aspectos
etiológicos
até
as
estratégias
terapêuticas,
proporcionando
uma
visão
holística
atualizada
dessa
médica.
Trata-se
revisão
integrativa,
resultou
em
12
artigos
para
análise
desta
revisão.
Os
resultados
apontam
que,
indivíduos
com
predisposição
genética
podem
apresentar
infiltração
da
esofágica
componentes
granulocíticos,
especificamente
basófilos,
como
resultado
consumo
certos
alimentos
leite
trigo.
Um
dos
benefícios
das
dietas
opção
terapêutica
elas
eliminam
necessidade
depender
medicamentos
crônicos
controlar
doença.
IBPs
são
escolha
eficaz
o
tratamento
farmacológico
EE,
quer
sejam
utilizados
isoladamente
combinação
outras
terapias.
Consequentemente,
crucial
enfatizar
importância
realização
mais
pesquisas,
incluindo
ensaios
clínicos
randomizados,
determinar
eficazes
podem,
última
análise,
melhorar
sintomas
bem-estar
nutricional
pacientes.
Russian Pediatric Journal,
Год журнала:
2024,
Номер
27(3), С. 218 - 227
Опубликована: Июль 12, 2024
Eosinophilic
esophagitis
(EoE)
is
a
chronic
immune-mediated
disease
characterized
by
esophageal
dysfunction
due
to
prolonged
eosinophilic
infiltration
of
tissues.
In
recent
years,
there
has
been
tendency
increase
the
prevalence
EoE,
which
may
lead
an
in
detection
strictures
children.
Aim:
determine
clinical
features
phenotype
with
outcome
stenosis
Materials
and
methods.
Seventy
children
diagnosed
EoE
were
examined,
9
(12.86%)
them
had
stenosis.
The
average
age
manifestation
was
6.17
years.
analysis
series
cases
carried
out
describe
disease.
At
same
time,
characteristics
patients
data
from
laboratory
instrumental
examination
methods,
including
esophagogastroduodenoscopy
biopsy,
used.
Results.
examined
patients,
delay
diagnosis
averaged
3
years
after
appearance
first
symptoms.
Early
manifestations
EOE
are
discomfort
when
swallowing
need
grind
food.
most
common
concomitant
gastroenterological
gastroesophageal
reflux
(GER).
All
food
allergies,
55
(77.8%)
allergic
cow’s
milk
proteins
(ACMP).
Esophageal
more
often
local,
lower
or
middle
third.
Inflammatory
changes
mucous
membrane
(MM)
esophagus
detected
all
patients;
ring-type
disorders
noted
47
(66.7%)
patients.
median
maximum
number
eosinophils
MM
30
per
0.3
mm2.
Subepithelial
fibrosis
observed
16
(22.2%)
62
(88.9%)
stopped
against
background
conservative
treatment.
Conclusion.
Increasing
awareness
necessary
reduce
time
for
diagnosis,
timely
treatment
risk
complications
form
