Role of METTL3 protein in asthma: Insights from transcriptomic profiling and molecular docking analysis

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Introduction Asthma is a chronic inflammatory disease characterized by complex immune dysregulation. This study aims to identify key m6A-related genes, particularly METTL3, as potential biomarkers and therapeutic targets in asthma. Methods Transcriptomic data from the GEO (GSE134544) dataset were analyzed differentially expressed genes. Functional enrichment analysis was performed using clusterProfiler, infiltration profiling conducted with CIBERSORT, competing endogenous RNA (ceRNA, including miRNA lncRNA) network constructed. Drug carried out DSigDB, molecular docking utilized assess interaction between Dabigatran METTL3 protein. Results From 192 four genes (METTL3, HNRNPC, IGFBP2, RBMX) identified hub Gene Ontology (GO) revealed significant biological processes related metabolic post-transcriptional regulation, while KEGG important pathways such spliceosome p53 signaling pathways. HNRNPC central ceRNA network, interacting miRNAs hsa-miR-93-3p lncRNAs like LINC01529. inhibitor, confirming stable binding affinity (-5.9 kcal/mol). Conclusion emphasizes critical role of macromolecules asthma pathophysiology, provides insights into their for treatment.

Язык: Английский

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Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 16, 2025

Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing global health burden. Systemic inflammation phenotypic ageing have been respectively reported to associate with certain CRD. However, little known about the co-exposures mutual associations Here, we aim systematically elucidate joint mediating systemic immune-inflammation index (SII) age acceleration (PhenoAgeAccel) CRD based on data from National Health Nutrition Examination Survey (NHANES). Data for this study was obtained NHANES 2007-2010 2015-2018. The single combined SII PhenoAgeAccel were analyzed using multivariable logistic regression models. dose-response relationship between exposures outcomes determined by restricted cubic splines (RCS) regression. Subgroup mediation analyses further conducted. Totally, 15,075 participants enrolled in including 3,587 patients. Compare controls, patients tended be older, females present higher values. Single-index analysis indicated that either or demonstrated significantly positive association via regressions RCS curves. Furthermore, joint-indexes revealed compared individuals lower PhenoAgeAccel, those exhibited remarkably stronger (adjusted OR [aOR], 1.56; 95% CI, 1.31-1.85; P < 0.001), chronic obstructive pulmonary disease (aOR, 1.22-2.00; = 0.001) asthma 1.40; 1.16-1.70; which predominant among aged above 40 years, smokers. Eventually, suggested effects mediated resulting more significantly. This confirmed coexposure effect We recommend assessment may conduce accurate identification populations susceptible early prevention diseases.

Язык: Английский

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Association between heavy metal exposure and asthma in adults: Data from the Korean National Health and Nutrition Examination Survey 2008–2013

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0319557 - e0319557

Опубликована: Март 10, 2025

Risk factors for asthma include genetic, host, and environmental such as allergens, smoking, exposure to chemicals. Heavy metals from air pollution or contaminated water food can also trigger asthma. This study aimed identify the biological levels of blood lead, mercury, cadmium, determine association with single multiple exposures these heavy using data Korean National Health Nutrition Examination Survey (KNHANES) conducted between 2008 2013. A weighted analysis 40,328 adults aged ≥ 20 years was conducted. Variables included metal levels, health behaviors, demographic characteristics, status. Logistic regression used odds ratio (OR) in adults. The overall prevalence 3.0%. geometric mean values cadmium were 2.14 μg/dL, 3.72 μg/L, 0.96 respectively. An high lead observed, highest level group showing a statistically significant association. Blood mercury significantly associated quartile levels. After adjusting behavior variables, associations persisted quartiles all metals. Multiple showed demonstrated adults, emphasizing need reduce preventive measure against

Язык: Английский

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Symptoms of Depression and Inhaler Adherence Among Adolescents With Asthma: Is There an Association?

Pediatric Pulmonology, Год журнала: 2025, Номер 60(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background The prevalence of depression among adolescents with asthma is reported to be 27%–34% across different geographical regions. Asthma control depends on inhaler adherence. Studies the association and adherence are few, especially in Indian subcontinent. Therefore, this study was carried out find its asthma. Methods A hospital‐based analytical cross‐sectional 102 a tertiary care setting. Symptoms were assessed using Center for Epidemiological Studies—Depression Scale Children (CES‐DC) Test Adherence Inhalers (TAI). Result Among asthma, detected 39 (38.2%). As per TAI scores, good, intermediate, poor inhalers were, respectively, found 35 (34.3%), 41 (40.2%), 26 (25.5%) On multivariable binary logistic regression analysis, intermediate inhalers, had 7.093 odds (95% CI 2.189–22.977) 9.002 CI: 2.501–32.405) having compared those good Those families whose monthly income INR 12,000 or less 2.490 1.002–6.187) more than family income. Conclusion level dose‐dependent manner lower independent predictors findings indicate need screen assess symptoms them manage appropriately, focusing low

Язык: Английский

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Omalizumab Safety Concerns

Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Elevated inflammatory burden index increases mortality in adults with chronic inflammatory airway diseases: a nationwide cohort study

BMC Pulmonary Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 20, 2024

The objective of this study was to investigate the potential association between inflammatory burden index (IBI) and prevalence chronic airway diseases (CIAD), as well mortality rates among individuals diagnosed with CIAD.

Язык: Английский

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Different Allergen-Induced Asthma and Anaphylaxis Show Distinctive IgE Pathway Dependence

Allergy medicine., Год журнала: 2024, Номер 2, С. 100010 - 100010

Опубликована: Сен. 19, 2024

Язык: Английский

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Asthma Updates: Theories Translated to Targeted Treatment

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2024, Номер 12(4), С. 908 - 910

Опубликована: Фев. 10, 2024

The research wheels of asthma fortunately continue to progress and, in some areas, provide advances that translate improved patient care and well-being. We hope readers Journal Allergy Clinical Immunology: In Practice (JACI Practice) will find, like we did, the topics this thematic issue on not only interest importance, but with direct links more informed care.

Язык: Английский

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Joint association of systemic immunue-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 11, 2024

Background Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing global health burden. Systemic inflammation phenotypic ageing have been respectively reported to associate with certain CRD. However, little known about the co-exposures mutual associations Here, we aim systematically elucidate joint mediating systemic immune-inflammation index (SII) age acceleration (PhenoAgeAccel) CRD based on data from National Health Nutrition Examination Survey (NHANES). Methods Data for this study was obtained NHANES 2007–2010 2015–2018. The single combined SII PhenoAgeAccel were analyzed using multivariable logistic regression models. dose-response relationship between exposures outcomes determined by restricted cubic splines (RCS) regression. Subgroup mediation analyses further conducted. Results Totally, 15,075 participants enrolled in including 3,587 patients. Compare controls, patients tended be older, females present higher values. Single-index analysis indicated that either or demonstrated significantly positive association via regressions RCS curves. Furthermore, joint-indexes revealed compared individuals lower PhenoAgeAccel, those exhibited remarkably stronger (adjusted OR [aOR], 1.53; 95% CI, 1.28–1.81; P < 0.001), chronic obstructive pulmonary disease (aOR, 1.58; 1.23–2.03; 0.001) asthma 1.37; 1.14–1.66; = 0.002), which predominant among aged above 40 years, smokers. Eventually, suggested effects mediated resulting more significantly. Conclusion This confirmed coexposure effect We recommend assessment may conduce accurate identification populations susceptible early prevention diseases.

Язык: Английский

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Prevalence of Obesity and Its Associated Comorbidities in Adults with Asthma: A Single-Center Study in Saudi Arabia

Medicina, Год журнала: 2024, Номер 60(11), С. 1785 - 1785

Опубликована: Окт. 31, 2024

Background and Objectives: Asthma is associated with several comorbidities, one of which obesity. The worldwide increase in obesity has been accompanied by a parallel rise asthma prevalence, recognized as significant risk factor for both the development severity asthma. Obesity often linked to various can complicate management lead poorer clinical outcomes. This study aims investigate prevalence its comorbidities adults single center Saudi Arabia, providing an overview health implications. Materials Methods: single-center, retrospective aimed assess other patients. Data were collected from King Khalid University Hospital Arabia between July 2023 December 2023. Results: revealed that 72.1% patients either obese or overweight. Female had significantly higher BMI values compared males. Our 38.21% female (mean age = 57 ± 13.85 years) 24.14% male 59 14.02 years). Furthermore, proportion asthmatic was greater than those without comorbidities. Conclusions: investigates adult asthmatics Arabia. findings reveal rate overweight among patients, comorbidity females. These results underscore need targeted interventions addressing especially asthmatics.

Язык: Английский

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