BMC Geriatrics, Год журнала: 2024, Номер 24(1)
Опубликована: Дек. 20, 2024
Язык: Английский
The journal of nutrition health & aging, Год журнала: 2025, Номер 29(1), С. 100401 - 100401
Опубликована: Янв. 1, 2025
Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span
Язык: Английский
Процитировано
21
Journal of Internal Medicine, Год журнала: 2024, Номер 296(5), С. 382 - 398
Опубликована: Окт. 1, 2024
Frailty and delirium are two common geriatric syndromes sharing several clinical characteristics, risk factors, negative outcomes. Understanding their interdependency is crucial to identify shared mechanisms implement initiatives reduce the associated burden. This literature review summarizes scientific evidence on complex interplay between frailty delirium; clinical, epidemiological, pathophysiological commonalities; current knowledge gaps. We conducted a PubMed systematic search in June 2023, which yielded 118 eligible articles out of 991. The synthesis results-carried by content experts-highlights overlapping phenotypes, outcomes explores influence one syndrome onset other. Common identified include inflammation, neurodegeneration, metabolic insufficiency, vascular suggests that factor for delirium, with some support accelerated frailty. proposed unifying framework supports integration measurement both constructs research practice, identifying geroscience approach as potential avenue develop strategies conditions. In conclusion, we suggest might be alternative-sometimes coexisting-manifestations biological aging. Clinically, concepts addressed this can help older adults either or from different perspective. From standpoint, longitudinal studies needed explore hypothesis specific pathways within biology aging may underlie manifestations delirium. Such will pave way future understanding other well.
Язык: Английский
Процитировано
7
Revista Española de Geriatría y Gerontología, Год журнала: 2025, Номер 60(4), С. 101646 - 101646
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
0
Clinical Interventions in Aging, Год журнала: 2024, Номер Volume 19, С. 1641 - 1652
Опубликована: Окт. 1, 2024
This study proposes a multiple mediation model to evaluate the association among diminished physical performance, malnutrition, inflammation, and delirium in seniors with community-acquired pneumonia.
Язык: Английский
Процитировано
4
Perioperative Medicine, Год журнала: 2025, Номер 14(1)
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
SSM - Mental Health, Год журнала: 2025, Номер unknown, С. 100408 - 100408
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Age and Ageing, Год журнала: 2025, Номер 54(2)
Опубликована: Фев. 1, 2025
Inpatient hospitalisation is associated with adverse outcomes in older adults, including hospital-associated deconditioning. The hospital-at-home (HaH) model may promote physical activity. This systematic review and meta-analysis compares functional between inpatient HaH settings evaluates the efficacy of exercise interventions both settings. Systematic searches PubMed, Scopus, Web Science ScienceDirect were conducted on 27 April 2024. Three distinct performed: (i) studies comparing hospitalisation, (ii) trials evaluating (iii) research interventions. Two reviewers independently selected published from 2014 onwards using PICOS framework they assessed quality PEDro scale. A was performed a random effects to analyse according PRISMA 2020 guidelines registered PROSPERO (CRD42024598286). Among 9470 identified, nine acute-care 21 (one HaH) included. Findings suggest that positively affect cognitive outcomes. significantly improved performance [standardised mean difference (SMD) = 0.42, 95% confidence interval (CI) 0.12-0.72] independence (SMD 0.45, CI 0.14-0.77) at discharge. contribute preserving status. Supervised during are safe effective for improving adults' status, although further needed.
Язык: Английский
Процитировано
0
BMC Geriatrics, Год журнала: 2024, Номер 24(1)
Опубликована: Дек. 20, 2024
Язык: Английский
Процитировано
2