Dynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics

Environment International, Год журнала: 2025, Номер 195, С. 109266 - 109266

Опубликована: Янв. 1, 2025

Polystyrene nanoplastics (PS-NPs) are omnipresent in the air and can be inhaled by humans. However, their long-term adverse implications toxicological mechanisms for human respiratory health unclear. Therefore, this study aims to provide new insights into pulmonary toxicity of PS-NPs using mice organoid models. After subacute subchronic inhalation PS-NPs, showed pronounced lung injury characterized rate changes, altered hematology, histological evidence tissue damage oxidative stress. Similarly, repeated exposure also restricted growth cause damage. Notably, through BisqueRNA analysis a single-cell dataset canonical markers verification, it was found that induced emergence accumulation transitional cells, suggesting impaired alveolar epithelial repair processes. Sequencing analyses revealed dynamic alterations non-coding RNA (ncRNA) profiles, including circRNAs lncRNAs, response exposure. Moreover, temporal profiling highlighted distinct sets ncRNAs as early progression-associated biomarkers PS-NP-induced injury. These correlated with aberrant implicating roles disrupted cellular differen tiation mechanisms. Overall, observed multifaceted responses system, emphasizing critical involvement mediating PS-NP-induce which crucial elucidating pathophysiology nanoplastic-induced developing targeted therapeutic strategies.

Язык: Английский

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PS-MPs or their co-exposure with cadmium impair male reproductive function through the miR-199a-5p/HIF-1α-mediated ferroptosis pathway

Environmental Pollution, Год журнала: 2023, Номер 339, С. 122723 - 122723

Опубликована: Окт. 12, 2023

Язык: Английский

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Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117711 - 117711

Опубликована: Янв. 1, 2025

Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis internal environment in patients with chronic diseases. The effects NP contamination on health chronically ill populations must urgently be elucidated. In this study, NPs injected via tail vein were distributed brain and organs mouse model carotid occlusion. Mice artery occlusion exposed showed behavioral abnormalities, such as depression anxiety, thus indicating detrimental brain. Subsequently, we used proteomics metabolomics analyze specific mechanisms underlying damaging deposition findings helped explain differences biochemical responses at microscopic level mice after exposure. not only accumulated caused pathologic damage, but also contributed accelerating atherosclerosis This work confirms risk elucidates mechanism harm; moreover, it provides theoretical support for developing strategies decrease microplastic intake

Язык: Английский

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Testicular Toxicity Assessment of Chronic Low-Dose Exposure to Polystyrene Nanoparticles in Multiexposure Models Using Drosophila

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Recent research has underscored the widespread presence of plastic in diverse ecosystems, prompting concerns about its potential long-term impacts on organisms. However, reproductive toxicity polystyrene nanoparticles (PSNPs) is contingent factors, such as drug concentrations, exposure duration, delivery method, and PSNP characteristics. Consequently, evaluation testicular stemming from chronic warrants a systematic investigation. This study extensively probed PSNPs testes using multiexposure models. Three distinct paradigms (adult, gestational, cross-generational exposure) were executed to assess PSNP-induced (80 nm) Drosophila. Nevertheless, spermatogenesis exhibited no discernible alterations following 75, 150, 300 μg/mL adult gestational Furthermore, did not perturb phenotype or offspring fertility F1 F4 generations. These findings imply that consumption low-dose may suffice induce dysfunction, providing fresh insights into dosage duration exposure.

Язык: Английский

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Micronanoplastic exposure due to cardiopulmonary bypass in children: a prospective observational study

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137732 - 137732

Опубликована: Фев. 23, 2025

Язык: Английский

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