Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107589 - 107589
Опубликована: Янв. 1, 2025
Bone
marrow
hematopoietic
injury
encompasses
a
range
of
pathological
conditions
that
disrupt
the
normal
function
system,
primarily
through
impaired
production
and
differentiation
bone
cells.
Key
pathogenic
mechanisms
include
aging,
radiation
damage,
chemical
induction,
infection
inflammation,
cross-talk
with
non-hematopoietic
diseases.
These
factors
often
lead
to
myelosuppression
myeloid
skewing.
Furthermore,
we
explored
potential
application
prospects
natural
products
in
treatment
injury.
Natural
products,
particularly
those
derived
from
Chinese
herbal
medicines
other
sources,
have
emerged
as
promising
therapeutic
options
due
their
distinctive
minimal
side
effects.
A
deeper
understanding
underlying
could
illuminate
how
exert
effects,
thereby
optimizing
strategies
offering
safer,
more
effective
for
patients.
Future
research
should
leverage
emerging
technologies
further
elucidate
composition
interactions
within
microenvironment,
well
specific
pathways
which
modulate
dysfunction.
Язык: Английский
Target discovery-directed pharmacological mechanism elucidation of bioactive natural products
Medical Review,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Abstract
Natural
products,
the
most
important
chemical
library
with
magical
structures
and
unique
functions,
have
long
been
playing
significant
roles
in
contributing
to
discovery
of
novel
drugs.
The
complexity
diversity
natural
products
present
great
challenges
regarding
exploration
their
potential
targets.
Identifying
targets
not
only
enhances
our
understanding
biological
functions
molecular
mechanisms,
but
also
paves
way
for
discovering
lead
compounds
disease
treatment.
Recent
advances
technologies
like
biology,
structural
artificial
intelligence
provided
powerful
tools
pinpointing
product
target
unraveling
mechanisms.
This
review
aims
comprehensively
summarize
innovative
strategies
employed
recent
years
identify
targets,
evaluate
impact
on
pathways
by
modulating
pharmacological
effects.
Moreover,
we
discuss
encountered
this
field
outline
future
research
prospects,
aiming
offer
guidance
researchers
biology.
Язык: Английский
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3381 - 3381
Опубликована: Апрель 4, 2025
The
global
rise
in
aging
populations
has
made
healthy
longevity
a
critical
priority
medical
research.
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside
(TSG),
the
primary
bioactive
component
of
Polygonum
multiflorum
Thunb.
(commonly
known
as
Fallopia
multiflora
Thunb.,
He
shou
wu,
Fo-ti,
or
Polygoni
multiflori
radix),
emerged
promising
agent
for
combating
and
age-related
diseases.
This
systematic
review
evaluates
anti-aging
properties
TSG
its
protective
effects
against
pathologies.
current
evidence
demonstrates
that
exhibits
comprehensive
effects,
including
lifespan
extension,
neuroprotection
(e.g.,
ameliorating
Alzheimer's
Parkinson's
diseases),
cardiovascular
protection
reducing
atherosclerosis
hypertension),
delay
gonadal
aging,
reduction
bone
loss
mitigating
osteoporosis),
promotion
hair
regrowth.
Mechanistically,
alleviates
oxidative
stress,
inflammation,
apoptosis
while
enhancing
mitophagy,
mitochondrial
function
telomerase
activity,
epigenetic
regulation.
These
multi-target
actions
align
with
holistic
principles
traditional
Chinese
medicine,
highlighting
TSG's
potential
multifaceted
agent.
However,
further
research
is
required
to
establish
standardized
quantitative
systems
evaluating
efficacy,
paving
way
broader
clinical
application
promoting
aging.
Язык: Английский