N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 29, 2025
N7-methylguanosine
(m7G)
is
an
important
RNA
modification
involved
in
epigenetic
regulation
that
commonly
observed
both
prokaryotic
and
eukaryotic
organisms.
Their
influence
on
the
synthesis
processing
of
messenger
RNA,
ribosomal
transfer
allows
m7G
modifications
to
affect
diverse
cellular,
physiological,
pathological
processes.
are
pivotal
human
diseases,
particularly
cancer
progression.
On
one
hand,
modification-associated
modulate
tumour
progression
malignant
biological
characteristics,
including
sustained
proliferation
signalling,
resistance
cell
death,
activation
invasion
metastasis,
reprogramming
energy
metabolism,
genome
instability,
immune
evasion.
This
suggests
they
may
be
novel
therapeutic
targets
for
treatment.
other
aberrant
expression
molecules
linked
clinicopathological
staging,
lymph
node
unfavourable
prognoses
patients
with
cancer,
indicating
their
potential
as
biomarkers.
review
consolidates
discovery,
identification,
detection
methodologies,
functional
roles
modification,
analysing
mechanisms
by
which
contribute
development,
exploring
clinical
applications
diagnostics
therapy,
thereby
providing
innovative
strategies
identification
targeted
Язык: Английский
Aberrant DNA methylation as a key modulator of cell death pathways: insights into cancer progression and other diseases
Ambreen Zahoor,
Rafia Khazer,
Insha Mehraj
и другие.
Functional & Integrative Genomics,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 1, 2025
Язык: Английский
Strategies to Mitigate Cisplatin-Induced Ototoxicity: A Literature Review of Protective Agents, Mechanisms, and Clinical Gaps
Alexandru Orasan,
M. M. Negru,
A. Morgovan
и другие.
Audiology Research,
Год журнала:
2025,
Номер
15(2), С. 22 - 22
Опубликована: Фев. 27, 2025
Background:
Cisplatin,
a
widely
used
chemotherapeutic
agent,
is
associated
with
significant
ototoxicity,
leading
to
progressive
and
irreversible
sensorineural
hearing
loss
in
up
93%
of
patients.
Cisplatin
generates
reactive
oxygen
species
(ROS)
the
cochlea,
activating
apoptotic
necroptotic
pathways
that
result
hair
cell
death.
Inflammatory
processes
nitrative
stress
also
contribute
cochlear
damage.
Methods:
This
literature
review
was
conducted
explore
mechanisms
underlying
cisplatin-induced
ototoxicity
evaluate
protective
strategies,
including
both
current
emerging
approaches.
A
structured
search
performed
multiple
scientific
databases,
PubMed
ScienceDirect,
for
articles
published
November
2024.
Results:
Current
otoprotective
strategies
include
systemic
interventions
such
as
antioxidants,
anti-inflammatory
agents,
apoptosis
inhibitors,
well
localized
delivery
methods
like
intratympanic
injection
nanoparticle-based
systems.
However,
these
approaches
have
limitations,
potential
interference
cisplatin’s
antitumor
efficacy
side
effects.
Emerging
focus
on
genetic
biomarker-based
risk
stratification,
novel
agents
targeting
alternative
pathways,
combination
therapies.
Repurposed
drugs
pravastatin
show
promise
reducing
ototoxicity.
Conclusions:
Despite
advancements,
research
gaps
remain
translating
preclinical
findings
clinical
applications
developing
selective
do
not
compromise
efficacy.
examines
mitigate
this
adverse
effect.
Язык: Английский
Astragalus membranaceus-Carthamus tinctorius herb pair antagonizes parthanatos in cerebral ischemia/reperfusion injury via regulating PARP-1/TAX1BP1-mediated mitochondrial respiratory chain complex I
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
unknown, С. 119260 - 119260
Опубликована: Дек. 1, 2024
Язык: Английский