Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 24, 2025

Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality morbidity rates globally. Shenmai injection (SMI), form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF. Recent research suggests that Medicine (TCM) may induce beneficial changes microbial-host co-metabolism, potentially providing cardiovascular protection. This study used rat model hypertensive heart (H-HF) to explore the mechanism SMI. The possible compounds key targets SMI against H-HF were investigated using network pharmacology. pharmacodynamics validated animal model, with analysis fecal gut microbiota integrating metabolomics 16S rRNA sequencing. Metorigin metabolite traceability MetaboAnalyst platform utilized action mechanism. To evaluate serum TMAO levels, targeted was performed. Finally, looked at intrinsic relationships among modifications intestinal flora, profile changes, clarify how they might be treat H-HF. According sequencing, reestablishing homeostasis microbiota, affects vital metabolic pathways, such as energy metabolism, amino acid bile metabolism. Increased levels identified risk factor for H-HF, able downregulate TMAO-related metabolites. Network pharmacology 13 active components targeting 46 proteins, resulting differential expression 8 metabolites 24 microbes. In conclusion, this highlights alleviating its potential modulate co-metabolism. Through comprehensive discussion interconnected components, targets, metabolites, it provided fresh light on therapeutic Not applicable.

Язык: Английский

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Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 14, 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving

Язык: Английский

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Dietary Triterpenoids in Functional Food and Drug Ingredients: a review of structure-activity relationships, biosynthesis, applications, and AI-driven strategies

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104961 - 104961

Опубликована: Март 1, 2025

Язык: Английский

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Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancer

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Авг. 26, 2024

Abstract Colorectal cancer (CRC) ranks as the third most prevalent globally. It’s recognized that molecular subtype of CRC, characterized by mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H), plays a critical role in determining appropriate treatment strategies. This review examines current classifications, focusing on dMMR/MSI-H CRC and its subtypes: Lynch syndrome (LS), Lynch-like (LLS), sporadic cases. Despite advances understanding these genetic backgrounds, clinical trials have not conclusively differentiated efficacy immune checkpoint inhibitors among subgroups. Therefore, while this details characteristics their general implications for prognosis, it also highlights limitations need more refined studies to ascertain tailored therapeutic strategies each subtype. Furthermore, summarizes completed ongoing studies, emphasizing importance developing treatments aligned closely with profiles. By discussing aspects, seeks provide comprehensive analysis oncological characteristics, presenting detailed prognosis CRC.

Язык: Английский

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Dianthus Superbus L. Alleviates Liver Injury Via Regulating Gut Microbiota-Mediated Tryptophan Metabolism

Опубликована: Янв. 1, 2025

IntroductionHepatic injury (HI), characterized by the impairment of liver tissue, can be precipitated a multitude factors including trauma, pharmacological agents, and pathologies, leading to spectrum functional anomalies associated clinical sequelae. Despite longstanding application Dianthus Superbus L. (DS) in management hepatic disorders, precise pathways through which it modulates gut microbiota their byproducts alleviate damage remain largely elusive.ObjectivesIts purpose is identify underlying mechanisms DS's therapeutic effects on CCL4-induced HI rats.MethodsDS components were analyzed using Ultra Performance Liquid Chromatography-Mass Spectrometer (UPLC-MS/MS).A 40% model SD rats was used evaluate efficacy DS biochemical marker assessment. Liver tissue examined immunohistochemically determine expression collagen-I -SMA, as well ZO-1 Occludin colon tissues. Non-targeted metabolomics analysis performed serum samples, while 16S rDNA targeted tryptophan conducted fecal samples. Further experiments investigating role included antibiotic treatment transplantation (FMT).ResultsThis study identified 30 chemical constituents DS, correlated with disease. Our findings indicate that induced CCL4 show an inhibition DS.A significant reduction mRNA levels α-SMA (p<0.05) Collagen I(p<0.05) detected immunohistochemistry, indicating decrease severity HI,and increase ZO-1(p<0.05) Occludin(p<0.05) colonic suggesting improvement intestinal barrier function. Similar trends observed α-SMA(p<0.05) I recipient underwent FMT DS. metabolomic indicated may exert hepatoprotective influencing biosynthesis steroid hormones, purine metabolism, metabolism. Analysis gene sequences demonstrated abundance beneficial bacterial groups such HT002, Lactobacillaceae, Lactobacillus, Romboutsia. Transplantation from DS-treated led enrichment Lactobacillus probiotics relative pseudo-sterile controls. Targeted feces restored multiple metabolites normal, improve modulating immune responses, reducing oxidative stress, enhancing function.ConclusionIn microbiota-dependent manner, ameliorates metabolism . It appears have potential use modulator prevention HI.

Язык: Английский

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Modulating the gut microbiota: A novel perspective in colorectal cancer treatment

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217459 - 217459

Опубликована: Янв. 1, 2025

Язык: Английский

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Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156417 - 156417

Опубликована: Янв. 1, 2025

Язык: Английский

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The association between the health of the intestines and the human body with Akkermansia muciniphila

The Microbe, Год журнала: 2025, Номер unknown, С. 100352 - 100352

Опубликована: Апрель 1, 2025

Язык: Английский

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Gut Microbiota-Mediated Biotransformation of Medicinal Herb-Derived Natural Products: A Narrative Review of New Frontiers in Drug Discovery

J — Multidisciplinary Scientific Journal, Год журнала: 2024, Номер 7(3), С. 351 - 372

Опубликована: Сен. 4, 2024

The discovery of natural products has been pivotal in drug development, providing a vast reservoir bioactive compounds from various biological sources. This narrative review addresses critical research gap: the largely underexplored role gut microbiota mediation and biotransformation medicinal herb-derived for therapeutic use. By examining interplay between products, this highlights potential microbiota-mediated to unveil novel agents. It delves into mechanisms by which microbes modify enhance efficacy with focus on herbal medicines Ayurveda traditional Chinese medicine, known their applications treating metabolic inflammatory diseases. also discusses recent advances microbiota-derived product research, including innovative methodologies such as culturomics, metagenomics, metabolomics. exploring intricate interactions microorganisms substrates, uncovers new strategies leveraging processes development groundbreaking therapeutics.

Язык: Английский

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