Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection DOI Creative Commons

Jun-Hong Xing,

Tianming Niu,

Tong Yu

и другие.

Microbiome, Год журнала: 2025, Номер 13(1)

Опубликована: Апрель 2, 2025

The Porcine Epidemic Diarrhea Virus (PEDV) is one of the major challenges facing global pig farming industry, and vaccines treatments have proven difficult in controlling its spread. Faecalibacterium prausnitzii (F.prausnitzii), a key commensal bacterium gut, has been recognized as promising candidate for next-generation probiotics due to potential wide-ranging health benefits. A decrease F.prausnitzii abundance associated with certain viral infections, suggesting application preventing intestinal infections. In this study, we utilized piglet model examine role PEDV infection was established supplemented F.prausnitzii, revealing that mitigated infection. Further studies found outer membrane vesicles (OMVs) are main functional components proteomics, untargeted metabolomics, small RNA-seq were used analyze composition OMVs. Exhaustion gut microbiota demonstrated function Fp. OMVs relies on presence microbiota. Additionally, metagenomic analysis indicated altered composition, enhancing prausnitzii, Prevotellamassilia timonensis, Limosilactobacillus reuteri. Untargeted metabolomics showed increased phosphatidylcholine (PC) levels, PC identified metabolite alleviating Single-cell sequencing revealed relative cells, number epithelial reduced necroptosis target cells. treatment infected IPEC-J2 Vero cells alleviated activation RIPK1-RIPK3-MLKL signaling axis, thereby improving play critical mitigating These findings provide strategy ameliorate piglets. Video Abstract.

Язык: Английский

Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection DOI Creative Commons

Jun-Hong Xing,

Tianming Niu,

Tong Yu

и другие.

Microbiome, Год журнала: 2025, Номер 13(1)

Опубликована: Апрель 2, 2025

The Porcine Epidemic Diarrhea Virus (PEDV) is one of the major challenges facing global pig farming industry, and vaccines treatments have proven difficult in controlling its spread. Faecalibacterium prausnitzii (F.prausnitzii), a key commensal bacterium gut, has been recognized as promising candidate for next-generation probiotics due to potential wide-ranging health benefits. A decrease F.prausnitzii abundance associated with certain viral infections, suggesting application preventing intestinal infections. In this study, we utilized piglet model examine role PEDV infection was established supplemented F.prausnitzii, revealing that mitigated infection. Further studies found outer membrane vesicles (OMVs) are main functional components proteomics, untargeted metabolomics, small RNA-seq were used analyze composition OMVs. Exhaustion gut microbiota demonstrated function Fp. OMVs relies on presence microbiota. Additionally, metagenomic analysis indicated altered composition, enhancing prausnitzii, Prevotellamassilia timonensis, Limosilactobacillus reuteri. Untargeted metabolomics showed increased phosphatidylcholine (PC) levels, PC identified metabolite alleviating Single-cell sequencing revealed relative cells, number epithelial reduced necroptosis target cells. treatment infected IPEC-J2 Vero cells alleviated activation RIPK1-RIPK3-MLKL signaling axis, thereby improving play critical mitigating These findings provide strategy ameliorate piglets. Video Abstract.

Язык: Английский

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