Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 28, 2024
Perivascular adipose tissue (PVAT) is a dynamic that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, disease complex plays pivotal role in pathogenesis of diseases such as atherosclerosis, hypertension, inflammation. In cardiometabolic diseases, PVAT becomes significant source proflammatory adipokines, leading to increased infiltration cells, proinflammatory promoting smooth muscle cell proliferation migrationpromoting migration. This exacerbates dysfunction by impairing endothelial activation. Dysregulated also contributes hemodynamic alterations hypertension through enhanced sympathetic nervous system activity impaired vasodilatory capacity PVAT-derived factors. Therapeutic interventions targeting key components this interaction, modulating inflammation, restoring adipokine balance, attenuating activation, hold promise for mitigating obesity-related complications. Lifestyle interventions, pharmacological agents inflammatory pathways, surgical approaches aimed at reducing mass or improving are potential therapeutic avenues managing associated with obesity dysfunction.
Язык: Английский