Pathogens,
Год журнала:
2023,
Номер
12(6), С. 766 - 766
Опубликована: Май 26, 2023
In
a
mutually
beneficial
connection
with
its
host,
the
gut
microbiota
affects
host's
nutrition,
immunity,
and
metabolism.
An
increasing
number
of
studies
have
shown
links
between
certain
types
disease
dysbiosis
or
specific
microorganisms.
Fecal
transplantation
(FMT)
is
strongly
advised
for
treatment
recurrent
resistant
Clostridium
difficile
infection
(CDI)
due
to
outstanding
clinical
effectiveness
against
CDI.
The
therapeutic
potential
FMT
other
disorders,
particularly
inflammatory
bowel
diseases
malignancies,
currently
gaining
more
attention.
We
summarized
most
recent
preclinical
evidence
show
promise
in
management
cancer
as
well
complications
related
after
reviewing
research
on
relationship
cancer.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
163, С. 114763 - 114763
Опубликована: Апрель 25, 2023
Gut
microbiota
can
interact
with
the
immune
system
through
its
metabolites.
Short-chain
fatty
acids
(SCFAs),
as
one
of
most
abundant
metabolites
resident
gut
play
an
important
role
in
this
crosstalk.
SCFAs
(acetate,
propionate,
and
butyrate)
regulate
nearly
every
type
cell
gut's
repertoire
regarding
their
development
function.
work
several
pathways
to
impose
protection
towards
colonic
health
against
local
or
systemic
inflammation.
Additionally,
a
regulation
non-immune
that
slow
autoimmunity
either
systematically
situ.
The
present
study
aims
summarize
current
knowledge
on
immunomodulatory
roles
association
between
autoimmune
disorders
such
celiac
disease
(CD),
inflammatory
bowel
(IBD),
rheumatoid
arthritis
(RA),
multiple
sclerosis
(MS),
lupus
erythematosus
(SLE),
1
diabetes
(T1D)
other
immune-mediated
diseases,
uncovering
brand-new
therapeutic
possibility
prevent
treat
autoimmunity.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114620 - 114620
Опубликована: Март 31, 2023
There
is
emerging
evidence
that
microbiota
and
its
metabolites
play
an
important
role
in
helath
diseases.
In
this
regard,
gut
has
been
found
as
a
crucial
component
influences
immune
responses
well
immune-related
disorders
such
autoimmune
Gut
bacterial
dysbiosis
shown
to
cause
disease
altered
metabolite
synthesis,
leading
immunological
metabolic
dysregulation.
Of
note,
the
produce
short-chain
fatty
acids
(SCFAs)
acetate,
butyrate,
propionate,
remodeling
these
linked
pathophysiology
of
number
type
1
diabetes,
multiple
sclerosis,
inflammatory
bowel
disease,
rheumatoid
arthritis,
celiac
systemic
lupus
erythematosus.
review,
we
will
address
most
recent
findings
from
noteworthy
studies
investigating
impact
SCFAs
on
various
Journal of Autoimmunity,
Год журнала:
2023,
Номер
141, С. 103038 - 103038
Опубликована: Апрель 26, 2023
Both
genetic
susceptibility
and
environmental
factors
are
important
contributors
to
autoimmune
disease
pathogenesis.
As
an
factor,
the
gut
microbiome
plays
a
crucial
role
in
development
progression
of
diseases.
Thus,
strategies
targeting
alterations
can
potentially
be
used
treat
disease.
Microbiota-based
interventions,
such
as
prebiotics,
probiotics,
dietary
fecal
microbiota
transplantation
(FMT),
have
attracted
growing
interest
novel
treatment
approaches.
FMT
is
effective
method
for
treating
recurrent
Clostridioides
difficile
infections;
moreover,
it
emerging
promising
patients
with
inflammatory
bowel
other
Although
mechanisms
underpinning
interaction
between
host
not
fully
understood
disease,
has
been
shown
restore
altered
composition,
rebuild
intestinal
microecosystem,
mediate
innate
adaptive
immune
responses
achieve
therapeutic
effect.
In
this
review,
we
provide
overview
discuss
how
approach
Furthermore,
recent
challenges
offer
future
research
directions.
Journal of Autoimmunity,
Год журнала:
2023,
Номер
141, С. 103114 - 103114
Опубликована: Сен. 23, 2023
The
gastrointestinal
tract
is
home
to
the
largest
microbial
population
in
human
body.
gut
microbiota
plays
significant
roles
development
of
immune
system
and
has
a
substantial
impact
on
maintenance
tolerance
beginning
early
life.
These
microbes
interact
with
dynamic
interdependent
manner.
They
generate
signals
by
presenting
vast
repertoire
antigenic
determinants
metabolites
that
influence
development,
maturation
immunological
function
homeostasis.
At
same
time,
both
innate
adaptive
systems
are
involved
modulating
stable
ecosystem
between
commensal
pathogenic
microorganisms.
Hence,
host
work
together
maintain
homeostasis
synergistically.
In
susceptible
hosts,
disruption
such
harmonious
state
can
greatly
affect
health
lead
various
auto-inflammatory
autoimmune
disorders.
this
review,
we
discuss
our
current
understanding
interactions
immunity
an
emphasis
on:
a)
important
players
immunity;
b)
contribution
metabolites;
c)
effect
as
well
alteration
microbiome
molecular
mechanisms
driving
autoimmunity
diseases.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 26, 2024
The
human
gastrointestinal
(GI)
tract
microbiome
is
a
complex
and
all-encompassing
ecological
system
of
trillions
microorganisms.
It
plays
vital
role
in
digestion,
disease
prevention,
overall
health.
When
this
delicate
balance
disrupted,
it
can
lead
to
various
health
issues.
Fecal
microbiota
transplantation
(FMT)
an
emerging
therapeutic
intervention
used
as
adjuvant
therapy
for
many
diseases,
particularly
those
with
dysbiosis
their
underlying
cause.
Its
goal
restore
by
transferring
fecal
material
from
healthy
donors
the
recipients.
FMT
has
impressive
reported
cure
rate
between
80%
90%
become
favored
treatment
diseases.
While
may
have
generally
mild
moderate
transient
adverse
effects,
rare
severe
complications
underscore
importance
rigorous
donor
screening
standardized
administration.
enormous
potential
practical
approach;
however,
additional
research
required
further
determine
its
clinical
utilization,
well
safety
efficiency
different
patient
populations.
This
comprehensive
literature
review
offers
increased
confidence
effectiveness
several
diseases
affecting
intestines
other
systems,
including
diabetes,
obesity,
inflammatory
autoimmune
illness,
conditions.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3494 - 3494
Опубликована: Фев. 9, 2023
Dysbiosis
has
been
identified
in
many
dermatological
conditions
(e.g.,
psoriasis,
atopic
dermatitis,
systemic
lupus
erythematosus).
One
of
the
ways
by
which
microbiota
affect
homeostasis
is
through
microbiota-derived
molecules
(metabolites).
There
are
three
main
groups
metabolites:
short-chain
fatty
acids
(SCFAs),
tryptophan
metabolites,
and
amine
derivatives
including
trimethylamine
N-oxide
(TMAO).
Each
group
its
own
uptake
specific
receptors
these
metabolites
can
exert
their
function.
This
review
provides
up-to-date
knowledge
about
impact
that
gut
may
have
conditions.
Special
attention
paid
to
effect
microbial
on
immune
system,
changes
profile
cells
cytokine
disbalance,
characteristic
several
diseases,
especially
psoriasis
dermatitis.
Targeting
production
serve
as
a
novel
therapeutic
approach
immune-mediated
diseases.
Abstract
Fecal
microbiota
transplantation
(FMT)
has
emerged
as
a
promising
therapeutic
approach
for
dysbiosis‐related
diseases.
However,
the
clinical
practice
of
crude
fecal
transplants
presents
limitations
in
terms
acceptability
and
reproductivity.
Consequently,
two
alternative
solutions
to
FMT
are
developed:
transplanting
bacteria
communities
or
virome.
Advanced
methods
mainly
include
washed
spores
treatment.
Transplanting
virome
is
also
explored,
with
development
transplantation,
which
involves
filtering
from
feces.
These
approaches
provide
more
palatable
options
patients
healthcare
providers
while
minimizing
research
heterogeneity.
In
general,
evolution
next
generation
global
trends
components
focuses
on
