Annals of the Rheumatic Diseases,
Год журнала:
2024,
Номер
83(8), С. 1006 - 1017
Опубликована: Март 26, 2024
Objective
Diffuse
central
nervous
system
manifestations,
referred
to
as
neuropsychiatric
lupus
(NPSLE),
are
observed
in
20–40%
of
patients
and
involve
complex
mechanisms
that
have
not
yet
been
adequately
elucidated.
In
murine
NPSLE
models,
choroid
plexus
(ChP)-infiltrating
T
cells
fully
evaluated
drivers
disease.
Method
Droplet-based
single-cell
transcriptomic
analysis
(single-cell
RNA
sequencing)
immune
T-cell
receptor
profiling
were
performed
on
ChP
tissue
from
MRL/lpr
mice,
an
mouse
model,
at
‘early’
‘late’
disease
state,
investigate
the
infiltrating
accumulate
with
progression.
Results
We
found
19
unique
clusters
stromal
present
mice.
Higher
resolution
uncovered
multiple
subsets,
increased
exhaustion
hypoxia
expression
profiles.
Clonal
revealed
clonal
CD8+T
cell
CDR3
sequence,
ASGDALGGYEQY,
matched
a
published
sequence
specificity
for
myelin
basic
protein.
Stromal
fibroblasts
likely
recruitment
by
upregulating
VCAM
signalling
pathway.
Systemic
blockade
VLA-4,
cognate
ligand
VCAM,
resulted
significant
infiltration
attenuation
depressive
phenotype.
Conclusion
Our
details
dynamic
changes
associated
progression,
highlights
its
potential
use
identifying
prospective
brain
therapeutic
targets.
ACS Nano,
Год журнала:
2024,
Номер
18(20), С. 13249 - 13265
Опубликована: Май 9, 2024
The
therapeutic
application
of
mesenchymal
stem
cells
(MSCs)
has
good
potential
as
a
treatment
strategy
for
systemic
lupus
erythematosus
(SLE),
but
traditional
MSC
therapy
still
limitations
in
effectively
modulating
immune
cells.
Herein,
we
present
promising
based
on
dexamethasone
liposome-integrated
MSCs
(Dexlip-MSCs)
treating
SLE
via
multiple
immunomodulatory
pathways.
This
prolonged
the
circulation
time
liposomes
vivo,
restrained
CD4+T-cell
proliferation,
and
inhibited
release
proinflammatory
mediators
(IFN-γ
TNF-α)
by
CD4+T
In
addition,
Dexlip-MSCs
initiated
cellular
reprogramming
activating
glucocorticoid
receptor
(GR)
signaling
pathway
to
upregulate
expression
anti-inflammatory
factors
such
cysteine-rich
secretory
protein
LCCL-containing
domain
2
(CRISPLD2)
downregulate
factors.
synergistically
increased
inhibitory
effect
through
or
Dex-integrated
MSC-derived
exosomes
(Dex-MSC-EXOs).
Based
these
synergistic
biological
effects,
demonstrated
that
alleviated
disease
progression
MRL/lpr
mice
more
than
Dexlip
alone.
These
features
indicate
our
cell
delivery
is
approach
clinical
treatment.
Arthritis Research & Therapy,
Год журнала:
2024,
Номер
26(1)
Опубликована: Март 3, 2024
Abstract
Objective
This
meta-analysis
aims
to
explore
the
potential
link
between
vaccines
and
systemic
lupus
erythematosus
(SLE).
Methods
We
systematically
searched
PubMed,
Cochrane
Library,
Embase
for
observational
studies
from
inception
September
3,
2023,
using
medical
subject
headings
(MeSH)
keywords.
Study
quality
was
assessed
NOS
scale.
Statistical
analyses
were
conducted
STATA
software
(version
14.0).
Publication
bias
evaluated
funnel
plots
Egger’s
regression.
Results
The
incorporated
17
studies,
encompassing
45,067,349
individuals
with
follow-up
periods
ranging
0.5
2
years.
pooled
analysis
revealed
no
significant
association
vaccinations
an
increased
risk
of
SLE
[OR
=
1.14,
95%
CI
(0.86–1.52),
I
78.1%,
P
0.348].
Subgroup
indicated
that
HBV
vaccination
significantly
associated
elevated
=2.11,
(1.11-4.00),
63.3%,
0.02],
HPV
slightly
1.43,
(0.88–2.31),
72.4%,
0.148],
influenza
showed
0.96,
(0.82–1.12),
0.0%,
0.559],
COVID-19
vaccine
marginally
a
decreased
0.44,
(0.18–1.21),
91.3%,
0.118].
Conclusions
study
suggests
are
not
linked
SLE.
Our
results
provide
valuable
insights,
alleviating
concerns
about
post-vaccination
supporting
further
development
efforts.
Annals of the Rheumatic Diseases,
Год журнала:
2024,
Номер
83(8), С. 1006 - 1017
Опубликована: Март 26, 2024
Objective
Diffuse
central
nervous
system
manifestations,
referred
to
as
neuropsychiatric
lupus
(NPSLE),
are
observed
in
20–40%
of
patients
and
involve
complex
mechanisms
that
have
not
yet
been
adequately
elucidated.
In
murine
NPSLE
models,
choroid
plexus
(ChP)-infiltrating
T
cells
fully
evaluated
drivers
disease.
Method
Droplet-based
single-cell
transcriptomic
analysis
(single-cell
RNA
sequencing)
immune
T-cell
receptor
profiling
were
performed
on
ChP
tissue
from
MRL/lpr
mice,
an
mouse
model,
at
‘early’
‘late’
disease
state,
investigate
the
infiltrating
accumulate
with
progression.
Results
We
found
19
unique
clusters
stromal
present
mice.
Higher
resolution
uncovered
multiple
subsets,
increased
exhaustion
hypoxia
expression
profiles.
Clonal
revealed
clonal
CD8+T
cell
CDR3
sequence,
ASGDALGGYEQY,
matched
a
published
sequence
specificity
for
myelin
basic
protein.
Stromal
fibroblasts
likely
recruitment
by
upregulating
VCAM
signalling
pathway.
Systemic
blockade
VLA-4,
cognate
ligand
VCAM,
resulted
significant
infiltration
attenuation
depressive
phenotype.
Conclusion
Our
details
dynamic
changes
associated
progression,
highlights
its
potential
use
identifying
prospective
brain
therapeutic
targets.
