Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Янв. 26, 2024
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such essential for sustaining host equilibrium, its impact on human health can be altered by variety factors such as external variables, social behavior, age, nutrition, genetics. Gut microbes’ imbalances are related to chronic diseases including cancer, obesity, digestive disorders. Globally, recent findings show that intestinal have significant role in the formation cardiovascular disease (CVD), which still primary cause fatalities. Atherosclerosis, hypertension, diabetes, inflammation, some inherited variables all risk variables. However, studies found correlations between metabolism, flora, dietary intake. Variations diversity changes their activity thought influence CVD etiology. Furthermore, microbiota acts an endocrine organ, producing bioactive metabolites TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), bile acids, substantial wellness multiple mechanisms. purpose this overview compile current evidence highlighting intricate links microbiota, metabolites, development CVD. It focuses how dysbiosis promotes heart failure, atherosclerosis. This review explores normal physiology potential techniques targeting bacteria treatment using various microbial metabolites. also examines significance treatment, supplements, prebiotics, probiotics, antibiotic therapies, fecal transplantation, innovative approach management As result, metabolic pathways become increasingly attractive targets intervention.
Язык: Английский
Процитировано
48
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(2), С. 217 - 217
Опубликована: Фев. 18, 2024
Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting
Язык: Английский
Процитировано
28
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
28
BMC Microbiology, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 5, 2024
Abstract Studying the effects of microbiome on development different types cancer has recently received increasing research attention. In this context, microbial content organs gastrointestinal tract been proposed to play a potential role in pancreatic (PC). Proposed mechanisms for pathogenesis PC include persistent inflammation caused by microbiota leading an impairment antitumor immune surveillance and altered cellular processes tumor microenvironment. The limited available diagnostic markers that can currently be used screening suggest importance composition as non-invasive biomarker clinical settings. Samples including saliva, stool, blood analyzed 16 s rRNA sequencing determine relative abundance specific bacteria. Studies have shown potentially beneficial prebiotics, probiotics, antibiotics, fecal transplantation, bacteriophage therapy altering diversity, subsequently improving treatment outcomes. review, we summarize impact PC, these microorganisms might biomarkers diagnosis determining prognosis patients. We also discuss novel methods being minimize or prevent progression dysbiosis modulating composition. Emerging evidence is supportive applying findings improve current therapeutic strategies employed PC.
Язык: Английский
Процитировано
24
Biomedicines, Год журнала: 2025, Номер 13(2), С. 422 - 422
Опубликована: Фев. 10, 2025
The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.
Язык: Английский
Процитировано
6
Microorganisms, Год журнала: 2024, Номер 12(1), С. 194 - 194
Опубликована: Янв. 18, 2024
Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically patients suffering from certain ailments. Although this knowledge was empirical past tomes, modern science has already verified it and expanded new limits. These microorganisms can be found nature various foods such as dairy products supplements formulated for clinical preventive use. The current review examines the different mechanisms of action probiotic strains how they interact with organism host. Emphasis is put on therapeutic use these beneficial conditions gastrointestinal tract. Diseases tract particularly any malfunction inflammation intestines seriously compromise whole organism. interaction between host’s microbiota alleviate signs symptoms while some cases, due course, intervene underlying pathology. Various safety issues probiotics also discussed.
Язык: Английский
Процитировано
17
Microorganisms, Год журнала: 2025, Номер 13(2), С. 445 - 445
Опубликована: Фев. 18, 2025
The role of gut microbiota (GM) and intestinal dysbiosis in triggering the onset and/or modulating severity progression lupus nephritis (LN) has been object intense research over last few years. Some alterations at phyla level, such as abundance Proteobacteria reduction Firmicutes/Bacteroidetes (F/B) ratio α-diversity have consistently reported systemic erythematosus (SLE), whereas a more specific ascribed to some species (Bacteroides thetaiotaomicron Ruminococcus gnavus) LN. Underlying mechanisms include microbial translocation through "leaky gut" subsequent molecular mimicry, immune dysregulation (alteration IFNγ levels balance between Treg Th17 subsets), epigenetic interactions. Levels bacterial metabolites, butyrate other short-chain fatty acids (SCFAs), appear play key Beyond components GM, virome mycobiome are also increasingly recognized important players modulation an response. On hand, microbiota-based therapy appears promising includes diet, prebiotics, probiotics, symbiotics, fecal transplantation (FMT). could correct critical alterations, F/B Treg/Th17 imbalance, blunt production autoantibodies renal damage. Despite current limits, GM is emerging powerful environmental factor that be harnessed interfere with leading SLE, preventing flares organ damage, including aim this review provide state-of-the-art analysis SLE LN on one while exploring possible therapeutic manipulation control disease hand.
Язык: Английский
Процитировано
2
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июнь 25, 2024
Depression, projected to be the predominant contributor global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication psychotherapy often fall short, prompting pursuit of alternative interventions. Recent research has highlighted significant role gut microbiota in mental health, influencing emotional neural regulation. Fecal transplantation (FMT), infusion fecal matter from healthy donor into patient, emerges promising strategy ameliorate depressive by restoring microbial balance. The microbial-gut-brain (MGB) axis represents critical pathway through which potentially rectify dysbiosis modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals reduce inflammatory markers, thereby alleviating behaviors. Moreover, shown promise clinical settings, improving gastrointestinal overall quality life patients depression. review highlights gut-brain depression need for further validate long-term safety efficacy FMT, identify specific therapeutic strains, develop targeted modulation strategies. Advancing our understanding could revolutionize treatment, shifting paradigm toward microbiome-targeting therapies.
Язык: Английский
Процитировано
8
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Дек. 4, 2024
Over recent years, studies on microbiota research and synthetic biology have explored novel approaches microbial manipulation for therapeutic purposes. However, fragmented information is available this aspect with key insights scattered across various disciplines such as molecular biology, genetics, bioengineering, medicine. This review aims to the transformative potential of in advancing microbiome therapies, significant implications healthcare, agriculture, environmental sustainability. By merging computer science, engineering, allows precise design modification biological systems via cutting edge technologies like CRISPR/Cas9 gene editing, metabolic oligonucleotide synthesis, thus paving way targeted treatments personalized probiotics engineered microorganisms. The will also highlight vital role gut disorders caused by its dysbiosis suggesting microbiota-based therapies innovations biosensors real-time health monitoring, non-invasive diagnostic tools, automated bio foundries better outcomes. Moreover, challenges including genetic stability, safety, robust regulatory frameworks be discussed understand importance ongoing ensure safe effective interventions.
Язык: Английский
Процитировано
8
Best Practice & Research Clinical Rheumatology, Год журнала: 2025, Номер unknown, С. 102035 - 102035
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1