International Immunopharmacology,
Год журнала:
2025,
Номер
155, С. 114624 - 114624
Опубликована: Апрель 10, 2025
Regulatory
T
cells
(Tregs)
are
a
specialized
subset
of
suppressive
that
essential
for
maintaining
self-tolerance,
regulating
effector
cells,
managing
microbial
infections,
preventing
tumors,
allergies,
and
autoimmune
disorders,
facilitating
allograft
transplantation.
Disruptions
in
Treg
function
or
abundance
contribute
to
an
imbalance
between
pathogenic
protective
immune
diseases.
Recently,
one
promising
treatment
strategy
restore
balance
involves
the
selective
expansion
manipulation
Tregs
using
low-dose
IL-2
therapy,
adoptive
cell
transfer,
chimeric
antigen
receptor
(CAR)-Treg
approaches.
have
been
shown
increasing
number
research
studies
prevent
even
treat
variety
such
as
allergic
diseases,
transplant
rejection,
graft-versus-host
disease.
A
thorough
comprehension
is
anticipated
provide
clear
prospects
effective
immunotherapy
wide
range
This
review
provides
overview
biology,
including
their
functions,
mechanisms,
phenotypic
markers,
well
involvement
disease
settings.
Furthermore,
we
discuss
therapeutic
potential
different
subpopulations
translational
applications
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 16, 2023
Alzheimer’s
disease
is
a
common
neurological
disorder,
which
has
become
one
of
the
major
factors
affecting
human
health
due
to
its
serious
impact
on
individuals,
families
and
society.
It
been
confirmed
that
gut
microbiota
can
affect
occurrence
development
disease.
Especially,
fecal
transplantation
plays
positive
role
in
treatment
The
mechanisms
for
improving
might
include
anti-inflammation
regulation
amyloid
β-protein,
synaptic
plasticity,
short-chain
fatty
acids,
histone
acetylation.
In
this
mini-review,
relationship
between
was
summarized.
hoped
would
play
prevention
future.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 10, 2024
Diabetes
mellitus
(DM)
refers
to
a
group
of
chronic
diseases
with
global
prevalence,
characterized
by
persistent
hyperglycemia
resulting
from
various
etiologies.
DM
can
harm
organ
systems
and
lead
acute
or
complications,
which
severely
endanger
human
well-being.
Traditional
treatment
mainly
involves
controlling
blood
sugar
levels
through
replacement
therapy
drugs
insulin;
however,
some
patients
still
find
satisfactory
curative
effect
difficult
achieve.
Extensive
research
has
demonstrated
close
correlation
between
enteric
dysbacteriosis
the
pathogenesis
types
DM,
paving
way
for
novel
therapeutic
approaches
targeting
gut
microbiota
manage
DM.
Fecal
transplantation
(FMT),
method
re-establishing
intestinal
microbiome
balance,
offers
new
possibilities
treating
diabetes.
This
article
provides
comprehensive
review
microbiota,
as
well
current
advancements
in
FMT
using
an
illustrative
example.
study
aims
offer
perspectives
establish
theoretical
foundation
clinical
diagnosis
management
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 9, 2024
The
gut
microbiota
offers
numerous
benefits
to
the
human
body,
including
promotion
of
nutrient
absorption,
participation
in
metabolic
processes,
and
enhancement
immune
function.
Recent
studies
have
introduced
concept
gut-organ
axis,
which
encompasses
interactions
such
as
gut-brain
gut-liver
gut-lung
axis.
This
underscores
complex
interplay
between
various
organs
tissues,
brain,
heart,
lungs,
liver,
kidneys,
muscles,
bones.
Growing
evidence
indicates
that
can
influence
onset
progression
multi-organ
system
diseases
through
their
effects
on
Traditional
Chinese
medicine
has
demonstrated
significant
efficacy
regulating
gastrointestinal
system,
leveraging
its
unique
advantages.
Considerable
advancements
been
made
understanding
role
axis
within
mechanisms
action
traditional
medicine.
review
aims
elucidate
roles
health,
explore
potential
connections
microbiota,
examine
therapeutic
microbiota-gut-organ
Furthermore,
addresses
limitations
challenges
present
current
research
while
proposing
directions
for
future
investigations
this
area.
Journal of Translational Autoimmunity,
Год журнала:
2025,
Номер
10, С. 100269 - 100269
Опубликована: Янв. 8, 2025
Autoimmune
rheumatic
diseases
(ARDs)
are
a
heterogeneous
group
of
conditions
characterized
by
excessive
and
misdirected
immune
responses
against
the
body's
own
musculoskeletal
tissues.
Their
exact
aetiology
remains
unclear,
with
genetic,
demographic,
behavioural
environmental
factors
implicated
in
disease
onset.
One
prominent
hypothesis
for
initial
breach
tolerance
(leading
to
autoimmunity)
is
molecular
mimicry,
which
describes
structural
or
sequence
similarities
between
human
microbial
proteins
(mimotopes).
This
similarity
can
lead
cross-reactive
antibodies
T-cell
receptors,
resulting
an
response
autoantigens.
Both
commensal
microbes
microbiome
pathogens
trigger
thereby
potentially
contributing
onset
ARDs.
In
this
review,
we
focus
on
role
mimicry
rheumatoid
arthritis
systemic
lupus
erythematosus.
Moreover,
implications
also
briefly
discussed
ankylosing
spondylitis,
sclerosis
myositis.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 4, 2025
Atrial
cardiomyopathy
is
a
multifaceted
heart
disease
characterized
by
structural
and
functional
abnormalities
of
the
atria
closely
associated
with
atrial
fibrillation
its
complications.
Its
etiology
involves
number
factors,
including
genetic,
infectious,
immunologic,
metabolic
factors.
Recent
research
has
highlighted
critical
role
gut
microbiota
in
pathogenesis
cardiomyopathy,
this
consistent
gut–heart
axis
having
major
implications
for
cardiac
health.
The
aim
work
to
bridge
knowledge
gap
regarding
interactions
between
particular
focus
on
elucidating
mechanisms
which
dysbiosis
may
induce
remodeling
dysfunction.
This
article
provides
an
overview
changes
composition
effects
metabolites.
We
also
discuss
how
diet
exercise
affect
influencing
microbiota,
as
well
possible
future
therapeutic
approaches
targeting
axis.
A
healthy
can
prevent
disease,
but
ecological
lead
variety
symptoms,
induction
disease.
pathophysiological
aspects
impact
structure
function,
strategies
exploring
modulation
treatment
cardiomyopathy.
Finally,
we
fecal
transplantation
oral
probiotics
or
prebiotics.
Our
study
highlights
importance
homeostasis
cardiovascular
health
suggests
that
targeted
interventions
pave
way
innovative
preventive
Biology,
Год журнала:
2025,
Номер
14(3), С. 251 - 251
Опубликована: Фев. 28, 2025
CRC
remains
a
significant
public
health
challenge
due
to
its
high
prevalence
and
mortality
rates.
Emerging
evidence
highlights
the
critical
role
of
gut
microbiota
in
both
pathogenesis
efficacy
treatment
strategies,
including
chemotherapy
immunotherapy.
Dysbiosis,
characterized
by
imbalances
microbial
communities,
has
been
implicated
progression
therapeutic
outcomes.
This
review
examines
intricate
relationship
between
composition
CRC,
emphasizing
potential
for
profiles
serve
as
biomarkers
early
detection
prognosis.
Various
interventions,
such
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
dietary
modifications,
aim
restore
balance
shift
dysbiosis
toward
eubiosis,
thereby
improving
Additionally,
integration
profiling
into
clinical
practice
could
enhance
diagnostic
capabilities
personalize
advancing
field
oncology.
The
study
intratumoral
offers
new
prognostic
tools
that,
combined
with
artificial
intelligence
algorithms,
predict
responses
assess
risk
adverse
effects.
Given
growing
understanding
microbiome–cancer
axis,
developing
microbiota-oriented
strategies
prevention
holds
promise
patient
care
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 587 - 587
Опубликована: Март 4, 2025
Fecal
microbiota
transplantation
(FMT)
is
the
most
effective
therapy
for
preventing
recurrent
Clostridioides
difficile
infection
(rCDI).
However,
impact
of
FMT
formulations
and
storage
conditions
on
bacterial
viability,
community
structure,
functionality,
clinical
efficacy
remains
under-investigated.
We
studied
effect
different
viability
(live/dead
staining
cell
sorting),
structure
(16S
rDNA
analysis),
metabolic
functionality
(fermentation)
frozen
lyophilized
formulations.
The
success
rates
rCDI
patients
were
correlated
retrospectively
with
formulations,
durations,
host
factors
using
Edmonton
program
database.
Bacterial
remained
at
10–20%
across
various
was
comparable
to
that
fresh
FMT.
Live
dead
fractions
in
both
preparations
exhibited
distinct
structures.
Storage
but
not
temperatures,
negatively
affected
diversity.
More
short-chain
fatty
acids
found
metabolomic
profiling
vitro
fermentation
products
than
Clinical
537
receiving
a
single
dose
significantly
among
three
longer
durations
advanced
recipient
age
impacted
efficacy.
Together,
our
findings
suggest
should
be
considered
when
establishing
guidelines
product
shelf
life
optimal
treatment
outcomes.
