International Urology and Nephrology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 16, 2024
Язык: Английский
Опубликована: Фев. 7, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, alters tryptophan metabolism with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-γ it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that induced kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-β. This cytokine primary determinant TME. Also proposed gut-lung concept consequent degradation ACE2 (richest lungs gut). Leaky autoantibodies related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. Aldosterone paroxysmal orthostatic tachycardia syndrome (POTS) paradoxes are highlighted context GPCR dysbiosis, role Candida explored. The triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry antigens, suppress inflammatory triad, balance TGF-β, depress KTR, elevate HRV, extend lifespan its quality.
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2024, Номер 135, С. 156191 - 156191
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Опубликована: Фев. 7, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, alters tryptophan metabolism with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-γ it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that induced kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-β. This cytokine primary determinant TME. Also proposed gut-lung concept consequent degradation ACE2 (richest lungs gut). Leaky autoantibodies related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. Aldosterone paroxysmal orthostatic tachycardia syndrome (POTS) paradoxes are highlighted context GPCR dysbiosis, role Candida explored. The triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry antigens, suppress inflammatory triad, balance TGF-β, depress KTR, elevate HRV, extend lifespan its quality.
Язык: Английский
Процитировано
0
Qeios, Год журнала: 2024, Номер unknown
Опубликована: Апрель 2, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role Candida explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens, suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.
Язык: Английский
Процитировано
0
Qeios, Год журнала: 2024, Номер unknown
Опубликована: Апрель 2, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role Candida explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens, suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.
Язык: Английский
Процитировано
0
Опубликована: Фев. 26, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, alters tryptophan metabolism with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-γ it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that induced kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-β. This cytokine primary determinant TME. Also proposed gut-lung concept consequent degradation ACE2 (richest lungs gut). Leaky autoantibodies related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. Aldosterone paroxysmal orthostatic tachycardia syndrome (POTS) paradoxes are highlighted context GPCR dysbiosis, role Candida explored. The efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry antigens, suppress inflammatory triad, balance TGF-β, depress KTR, elevate HRV, extend lifespan its quality.
Язык: Английский
Процитировано
0
Опубликована: Март 27, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role Candida explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens, suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.
Язык: Английский
Процитировано
0
Pediatrics Consilium Medicum, Год журнала: 2024, Номер 2, С. 173 - 178
Опубликована: Окт. 16, 2024
New data on the association of intestinal microbiome changes with some serious diseases raised question role bacteria living in intestine maintaining human health. One way to study composition and function adjust it is fecal microbiota transplantation (FMT), which refers transfer donor's into recipient's body modify species diversity. Currently, FMT included standards care for relapsed refractory types clostridial infection many countries. Its possible effect course such as inflammatory bowel disease, irritable syndrome, metabolic neurological other being studied. Fecal biomaterial storage banks have been established Europe, Asia, USA facilitate donor selection, delivery recipient simplify control procedure, safety adverse events. In Australia, a medicinal product approved, includes feces specially examined prepared donors. Despite unresolved technological, legal ethical issues, has already promising potential treatment diseases.
Язык: Английский
Процитировано
0
Опубликована: Ноя. 1, 2024
Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. a required cofactor for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. in synthesis vitamin D melatonin activation five eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.
Язык: Английский
Процитировано
0
Qeios, Год журнала: 2024, Номер 6(11)
Опубликована: Ноя. 12, 2024
Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for nearly a thousand enzymatic reactions. This narrative review does correlate status with clinical data on agents linked to longevity. The approach more novel highlights specific dependent physiologic reactions by these longevity biomarkers. Many share common pathways extend healthspan. cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented, although cause effect awaits publication supporting data.
Язык: Английский
Процитировано
0