Experimental verification of Myriocin molecular bioactivity in revoking rheumatoid arthritis: New emphasis on S100A1 repression and PPAR-γ activation via non-canonical pathways in the flare-up of cytokines

International Immunopharmacology, Год журнала: 2025, Номер 158, С. 114811 - 114811

Опубликована: Май 11, 2025

Язык: Английский

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IGF2BP3-mediated m6A modification of RASGRF1 promoting joint injury in rheumatoid arthritis

Bone Research, Год журнала: 2025, Номер 13(1)

Опубликована: Май 12, 2025

Abstract With the deepening of epigenetic research, studies have shown that N 6 -methyladenosine (m A) is closely related to development rheumatoid arthritis (RA), but mechanism still unclear. In study, we collected synovial tissues from normal controls and patients with osteoarthritis (OA) or RA. The levels m A inflammation were analyzed by immunofluorescence staining western blotting. roles IGF2BP3 in cell proliferation inflammatory activation explored using transfection RNA immunoprecipitation assays. −/− mice generated used establish an mouse model transferring serum adult K/BxN mice. We found markedly increased RA models, expression was upregulated individuals markers. played important part RA-fibroblast-like synoviocytes (FLS) promoting proliferation, migration, invasion, cytokine release inhibiting autophagy. addition, inhibited autophagy reduce ROS production, thereby decreasing macrophages. More importantly, RASGRF1-mediated mTORC1 a crucial role ability promote activation. mice, knockout RA-FLS infiltration, further ameliorated joint injury. Our study revealed for progression. targeted inhibition reduced limited development, providing potential strategy therapy.

Язык: Английский

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Berberine Mediates Exosomes Regulating the Lipid Metabolism Pathways to Promote Apoptosis of RA-FLS Cells

Pharmaceuticals, Год журнала: 2024, Номер 17(11), С. 1509 - 1509

Опубликована: Ноя. 9, 2024

: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint damage and commonly linked to symptoms such as inflammation, swelling, pain. Traditional Chinese Medicine offers complementary integrative approaches in the management of rheumatoid arthritis, potentially providing additional options that may help address treatment challenges enhance overall patient care. This paper explores mechanism action berberine from perspective cellular exosomes mediating exosomal contents thus treating RA.

Язык: Английский

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The Therapeutic Mechanisms of Huayu Quban Capsule in Treating Acne Vulgaris Are Uncovered Through Network Pharmacology and Molecular Docking

Journal of Cosmetic Dermatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 17, 2024

To uncover how the Huayu Quban (HYQB) capsule treats acne vulgaris (AV) through use of network pharmacology and molecular docking technology.

Язык: Английский

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