Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 27, 2024

T helper (Th) 17 cells, a distinct subset of Th lymphocytes, are known for their prominent interleukin (IL)-17 production and other pro-inflammatory cytokines. These cells exhibit remarkable plasticity, allowing them to different phenotypes in the cancer microenvironment. This adaptability enables Th17 promote tumor progression by immunosuppressive activities angiogenesis, but also mediate anti-tumor immune responses through employing setting or even directly converting toward Th1 phenotype producing interferon-gamma (IFN-γ). dual role makes it double-edged sword encountering cancer. In this review, we aim elucidate complexities cell function summarizing recent studies and, ultimately, design novel therapeutic strategies, especially targeting milieu, which could pave way more effective treatments.

Язык: Английский

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Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

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Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

Опубликована: Май 20, 2024

The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis and skin psoriasis, albeit only subsets individuals each condition. This suggests intersecting "nodes" networks at a molecular cellular level may drive and/or maintain IMIDs, being “shared” between traditionally diagnoses without mapping neatly to single clinical phenotype. In line this proposition, integrative tumour tissue analyses oncology have highlighted novel cell states acting across diverse cancers, important implications precision medicine. Drawing upon advances field, narrative review will first summarise learnings from Human Cell Atlas health as platform interrogating IMID tissues. It then cross-disease studies date inform endeavour, before considering future directions field.

Язык: Английский

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Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

Опубликована: Июнь 6, 2024

The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis and skin psoriasis, albeit only subsets individuals each condition. This suggests intersecting "nodes" networks at a molecular cellular level may drive and/or maintain IMIDs, being “shared” between traditionally diagnoses without mapping neatly to single clinical phenotype. In line this proposition, integrative tumour tissue analyses oncology have highlighted novel cell states acting across diverse cancers, important implications precision medicine. Drawing upon advances field, narrative review will first summarise learnings from Human Cell Atlas health as platform interrogating IMID tissues. It then cross-disease studies date inform endeavour, before considering future directions field.

Язык: Английский

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Leveraging Multi-Tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

Biomedicines, Год журнала: 2024, Номер 12(6), С. 1297 - 1297

Опубликована: Июнь 12, 2024

The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis, and skin psoriasis, albeit only subsets individuals each condition. This suggests intersecting “nodes” networks at a molecular cellular level may drive and/or maintain IMIDs, being “shared” between traditionally diagnoses without mapping neatly to single clinical phenotype. In line this proposition, integrative tumour tissue analyses oncology have highlighted novel cell states acting across diverse cancers, important implications precision medicine. Drawing upon advances field, narrative review will first summarise learnings from Human Cell Atlas health as platform interrogating IMID tissues. It then cross-disease studies date inform endeavour before considering future directions field.

Язык: Английский

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Longitudinal analysis at pre- and post-flare of T peripheral helper and T follicular helper subsets in patients with systemic lupus erythematosus

Immunology Letters, Год журнала: 2024, Номер 269, С. 106905 - 106905

Опубликована: Авг. 3, 2024

We focused to analyze the time-course changes at pre- and post-flare of T peripheral helper (Tph) cells circulating follicular (Tfh) in blood patients with systemic lupus erythematosus (SLE) low disease activity state (LLDAS) before flare.

Язык: Английский

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