O-GlcNAcAtlas 4.0: An updated protein O-GlcNAcylation database with site-specific quantification

Journal of Molecular Biology, Год журнала: 2025, Номер unknown, С. 169033 - 169033

Опубликована: Фев. 1, 2025

Язык: Английский

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Quantitative and site-specific chemoproteomic profiling of O-GlcNAcylation in Drosophila

Bioorganic & Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 118191 - 118191

Опубликована: Апрель 1, 2025

Язык: Английский

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Glucose sensing and the unfolded protein response

FEBS Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

The unfolded protein response (UPR) is activated primarily upon alteration of folding in the endoplasmic reticulum (ER). This occurs under physiological situations that cause an abrupt increase synthesis, or redox and metabolic stresses. Among latter, hyperglycemia glucose scarcity have been identified as major modulators UPR signaling. Indeed, first mammalian effector, glucose‐regulated 78, also known BiP, was to deprivation. Tunicamycin, arguably most commonly used drug induce ER stress responses vitro vivo , inhibitor N ‐glycosylation. We compile here evidence pathological conditions alter levels this mostly mediated by alterations ‐glycosylation, ATP levels, balance. three branches transduced PERK/ATF4, IRE1/XBP1s, ATF6, well non‐canonical sensors such SCAP/SREBP, sense glycosylation status driven other glucose‐derived metabolites. outcomes activation range from restoring ‐glycosylation flux stimulating autophagy, organelle recycling, mitochondrial respiration, some cases, cell death. Anabolic are stimulated through components UPR. Therefore, should be further studied a potential biomarker mediator glucose‐associated diseases.

Язык: Английский

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O-GlcNAc informatics: advances and trends

Analytical and Bioanalytical Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

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