Activating Transcription Factor 3 regulates hepatic Apolipoprotein A4 upon metabolic stress DOI Creative Commons

Jasmine Encarnacion,

Dirk E. Smith,

Joseph Choi

и другие.

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108468 - 108468

Опубликована: Март 1, 2025

The liver plays essential roles in maintaining systemic glucolipid homeostasis under ever changing metabolic stressors. Metabolic dysregulation can lead to both adaptive and maladaptive changes that impact physiology. Here we examined disparate genetic environmental stressors identified Apolipoprotein A4 (ApoA4) as a circulating protein upregulated liver-specific knockouts for Carnitine Palmitoyltransferase 2 Pyruvate Carboxylase. We found this upregulation be exacerbated by fasting high fat or ketogenic diets. Unique among these models was concomitant increase Activating Transcription Factor 3 (Atf3). Liver-specific overexpression of Atf3 resulted increased ApoA4 expression sex-dependent manner. To understand the requirement stress, generated Atf3, Cpt2 double knockout mice. These experiments demonstrated induction mRNA, protein, serum triglycerides were also sex dependent. reveal hepatic response stress vivo.

Язык: Английский

Activating Transcription Factor 3 regulates hepatic Apolipoprotein A4 upon metabolic stress DOI Creative Commons

Jasmine Encarnacion,

Dirk E. Smith,

Joseph Choi

и другие.

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108468 - 108468

Опубликована: Март 1, 2025

The liver plays essential roles in maintaining systemic glucolipid homeostasis under ever changing metabolic stressors. Metabolic dysregulation can lead to both adaptive and maladaptive changes that impact physiology. Here we examined disparate genetic environmental stressors identified Apolipoprotein A4 (ApoA4) as a circulating protein upregulated liver-specific knockouts for Carnitine Palmitoyltransferase 2 Pyruvate Carboxylase. We found this upregulation be exacerbated by fasting high fat or ketogenic diets. Unique among these models was concomitant increase Activating Transcription Factor 3 (Atf3). Liver-specific overexpression of Atf3 resulted increased ApoA4 expression sex-dependent manner. To understand the requirement stress, generated Atf3, Cpt2 double knockout mice. These experiments demonstrated induction mRNA, protein, serum triglycerides were also sex dependent. reveal hepatic response stress vivo.

Язык: Английский

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