Palladium-Catalyzed Difluorocarbene Transfer Enabled Divergent Synthesis of γ-Butenolides and Ynones from Iodobenzene and Terminal Alkynes
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(2), С. 1722 - 1731
Опубликована: Янв. 4, 2024
Herein,
we
report
a
ligand-controlled
palladium-catalyzed
method
that
enables
the
synthesis
of
ynones
and
γ-butenolides
with
excellent
regioselectivity
from
same
set
readily
available
aryl
iodides,
acetylenes,
BrCF2CO2K.
In
this
reaction,
[PdII]═CF2
does
demonstrate
electrophilicity
can
generate
CO
when
reacting
H2O.
It
is
environmentally
friendly
safe
compared
to
traditional
methods,
current
protocol
us
afford
in
high
yields
functionality
tolerance.
Moreover,
esters
also
be
obtained
corresponding
phenols
alcohols
utilizing
strategy.
The
success
late-stage
functionalization
bioactive
compounds
further
illustrates
synthetic
utility
material
development
drug
discovery.
Язык: Английский
Palladium-Catalyzed Cascade Carbonylation Reaction To Construct Ester Derivatives
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
We
have
developed
a
palladium-catalyzed
ester
carbonylation
reaction
that
enables
the
synthesis
of
ester-substituted
benzofuran
derivatives
in
single
step
through
introduction
alkyl
halides
undergoing
situ
hydrolysis
and
alkynyl
aryl
iodides.
This
method
demonstrates
broad
applicability
to
both
primary
secondary
while
maintaining
excellent
functional
group
compatibility
under
low
palladium
loading
conditions.
Notably,
this
strategy
significantly
expands
scope
reactions.
Язык: Английский
Pd-Catalyzed Cascade Heck Cyclization/Carbonylation of Indoles with Aryl Formates: Enantioselective Construction of Indolo[2,1-a]isoquinolines
Chemical Communications,
Год журнала:
2024,
Номер
60(65), С. 8613 - 8616
Опубликована: Янв. 1, 2024
A
palladium-catalyzed
enantioselective
intramolecular
Heck
cyclization/carbonylation
reaction
has
been
developed,
which
utilizes
formates
as
the
source
of
CO
to
enantioselectively
synthesize
ester-substituted
indolo[2,1-
a
]isoquinolines.
Язык: Английский
Silver-Catalyzed 5-Exo-dig Cyclization Reaction of ortho-Hydroxyphenylpropargyl Alcohols to 2-Methylene-2,3-dihydrobenzofuran
Miao Feng,
Lanlan Lü,
Yijia Guo
и другие.
Chinese Journal of Organic Chemistry,
Год журнала:
2024,
Номер
44(4), С. 1218 - 1218
Опубликована: Янв. 1, 2024
摘要
2-亚甲基-2,3-二氢苯并呋喃衍生物作为多种天然产物及药物的核心骨架之一,
寻找由简便易得原料有效合成
2-亚甲基-2,3-二氢苯并呋喃的新方法具有重要的意义.开发了一种新的银催化邻羟基苯基炔丙醇的
5-exo