Photoredox-Catalyzed Amino-Radical-Transfer-Mediated Three-Component Alkylarylation of Alkenes

Organic Letters, Год журнала: 2024, Номер 26(30), С. 6477 - 6481

Опубликована: Июль 23, 2024

We herein reported a novel photoredox-catalyzed three-component alkylarylation of vinyl arenes with alkylboronic pinacol esters (APEs) and cyanoarenes via radical addition/cross-coupling to construct 1,1-diarylalkanes. In this transformation, alkyl radicals were easily available by visible-light-induced oxidative N-H cleavage morpholine, which used APEs as precursor. Furthermore, protocol exhibited broad substrate scope, enabling various styrenes, APEs, cyanoarenes, well bioactive molecule derivatives.

Язык: Английский

Iron-Catalyzed Aminoalkylative Carbonylative Cyclization of Alkenes toward α-Tetralones

Organic Letters, Год журнала: 2024, Номер 26(15), С. 3140 - 3144

Опубликована: Апрель 2, 2024

Carbonylative multifunctionalization of alkenes is an efficient approach to introduce multiple functional groups into one molecule from easily available materials. Herein, we developed iron-catalyzed radical relay carbonylative cyclization with acetamides. Various α-tetralones can be constructed in moderate yields readily substrates earth-abundant iron salt as the catalyst.

Язык: Английский

Iron-Assisted and Cu-Mediated Direct Aminocarbonylation of Nitroarene with Boronic Acid

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Herein, we have established the formation of diaryl amide by aminocarbonylation nitrobenzene with boronic acids. The method works in catalytic presence economical and commercially available CuI salt, which was significantly promoted Fe

Язык: Английский