Dopamine and Mn(II) Chelate Covalent-Doping Coated Ti(IV)-Nanotheranostics for Magnetic Resonance Imaging Guided Phototherapy in Oral Cancer DOI Creative Commons
Zhenghui Li,

Xufei Bian,

Hui-Yu Wu

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6043 - 6057

Опубликована: Май 1, 2025

Phototherapy have gained significant traction in the treatment of tumors. However, successful implementation these therapies relies on photosensitizers with superior properties and precise guidance mechanisms. In this study, we introduce an innovative method for surface modification titanium dioxide (TiO2) nanoparticles through HRP-catalyzed covalent incorporation Mn(II) chelate (Mn-Dopa) dopamine. This extends TiO2 nanoparticels' light absorption from ultraviolet to near-infrared (NIR) range, endowing MRI-guided phototherapy capabilities. The resulting nanotheranostics system, TiO2@PDA-MnDopa, demonstrated over 5-fold enhanced relaxivity compared monomeric MnDopa exhibited synergistic effects upon 808 nm laser excitation, a photothermal conversion efficiency 15.91%. vitro vivo pharmacodynamics studies showed that TiO2@PDA-MnDopa good safety HSC3 cell line corresponding tumor-bearing mice, while effectively inhibiting tumor growth under excitation. multifunctional nanotheranostic, integrating high PTT/PDT MR imaging-guided phototherapy, holds great potential applications early diagnosis, noninvasive treatment, prognostic evaluation oral squamous carcinoma.

Язык: Английский

Surface functionalization of rutile TiO2 extracted from Egyptian ilmenite with titanosilicate for enhanced photocatalytic and ion removal performance DOI
Eman Z. Hegazy, Islam Hamdy Abd El Maksod,

Shaymaa El-Shafey

и другие.

Applied Surface Science, Год журнала: 2025, Номер unknown, С. 163135 - 163135

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Dopamine and Mn(II) Chelate Covalent-Doping Coated Ti(IV)-Nanotheranostics for Magnetic Resonance Imaging Guided Phototherapy in Oral Cancer DOI Creative Commons
Zhenghui Li,

Xufei Bian,

Hui-Yu Wu

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6043 - 6057

Опубликована: Май 1, 2025

Phototherapy have gained significant traction in the treatment of tumors. However, successful implementation these therapies relies on photosensitizers with superior properties and precise guidance mechanisms. In this study, we introduce an innovative method for surface modification titanium dioxide (TiO2) nanoparticles through HRP-catalyzed covalent incorporation Mn(II) chelate (Mn-Dopa) dopamine. This extends TiO2 nanoparticels' light absorption from ultraviolet to near-infrared (NIR) range, endowing MRI-guided phototherapy capabilities. The resulting nanotheranostics system, TiO2@PDA-MnDopa, demonstrated over 5-fold enhanced relaxivity compared monomeric MnDopa exhibited synergistic effects upon 808 nm laser excitation, a photothermal conversion efficiency 15.91%. vitro vivo pharmacodynamics studies showed that TiO2@PDA-MnDopa good safety HSC3 cell line corresponding tumor-bearing mice, while effectively inhibiting tumor growth under excitation. multifunctional nanotheranostic, integrating high PTT/PDT MR imaging-guided phototherapy, holds great potential applications early diagnosis, noninvasive treatment, prognostic evaluation oral squamous carcinoma.

Язык: Английский

Процитировано

0