Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Язык: Английский

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Calycosin regulates astrocyte reactivity and astrogliosis after spinal cord injury by targeting STAT3 phosphorylation

Journal of Neuroimmunology, Год журнала: 2025, Номер 400, С. 578535 - 578535

Опубликована: Янв. 30, 2025

Язык: Английский

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Phytochemical Profile and Antioxidant Activity of the Tuber and Peel of Pachyrhizus erosus

Antioxidants, Год журнала: 2025, Номер 14(4), С. 416 - 416

Опубликована: Март 31, 2025

This study systematically investigated the antioxidant activities and phytochemical profiles of petroleum ether (PE), ethyl acetate (EtOAc), n-butanol (n-BuOH) aqueous fractions edible (tubers) non-edible portions (peels) Pachyrhizus erosus. The results showed that both tubers peels from P. erosus were rich in polyphenols flavonoids, whereas EtOAc fraction had highest polyphenol content, PE total flavonoid content. ABTS, DPPH, FRAP assays revealed significant activity, possessed better activity than tubers. UPLC-Orbitrap-MS/MS analysis indicated thirty compounds identified tubers, including twenty-one six phenolics, two coumarins, one lignan, some which have previously been to display anti-inflammatory effects via Nrf2-Keap1 NF-κB signaling pathways. These findings provide robust scientific evidence for health-promoting properties pharmaceutical potential erosus, its portion has great use as a natural food, cosmetic, industries.

Язык: Английский

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Neuropharmacological effects of calycosin: a translational review of molecular mechanisms and therapeutic applications

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

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