Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action DOI Open Access
Manuela Malatesta,

Gabriele Tabaracci,

C. Pellicciari

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12657 - 12657

Опубликована: Ноя. 25, 2024

Ozone (O

Язык: Английский

Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury DOI Creative Commons

Yuping Ma,

X Wang,

Yahui Li

и другие.

Journal of Integrative Neuroscience, Год журнала: 2025, Номер 24(3)

Опубликована: Март 18, 2025

Ischemic stroke (IS) constitutes a major threat to human health. Vascular recanalization by intravenous thrombolysis and mechanical remain the most significant effective methods for relief of ischemia. Key elements these treatments include achieving blood-vessel recanalization, restoring brain-tissue reperfusion, preserving ischemic penumbra. However, in therapeutic goals vascular secondary damage brain tissue from cerebral ischemia-reperfusion injury (CIRI) must also be addressed. Despite advancements understanding pathological processes associated with CIRI, interventions prevent its onset progression are still lacking. Recent research has indicated that mitophagy ferroptosis critical mechanisms development significantly contribute IS CIRI because common targets co-occurrence mechanisms. Therefore, exploring summarizing potential connections between during is crucial. In present review, we mainly focused on mitochondrial autophagy ferroptosis, their interaction, CIRI. We believe data show strong relationship interactive regulation. This information may underpin new approaches prevention treatment subsequent

Язык: Английский

Процитировано

1
Nuclear factor erythroid 2-related factor-mediated signaling alleviates ferroptosis during cerebral ischemia-reperfusion injury DOI Open Access
Zheng Li, Jihong Xing

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117513 - 117513

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

3
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

и другие.

Expert Opinion on Therapeutic Targets, Год журнала: 2024, Номер unknown, С. 1 - 27

Опубликована: Дек. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Язык: Английский

Процитировано

3
The Molecular Key to Understanding the Medical Ozone Action DOI Creative Commons
Lamberto Re

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6148 - 6148

Опубликована: Июнь 3, 2024

Currently, treatment with medical ozone (MO) is considered one of the most interesting and safe integrative options that can effectively complement many conventional therapies, mainly, but not exclusively, involving aging pain [...]

Язык: Английский

Процитировано

1
Role of miRNA regulation in IGFBP-2 overexpression and neuronal ferroptosis: Insights into the Nrf2/SLC7A11/GPX4 pathway in Alzheimer's disease DOI
Chen Luo,

Guiyou Wu,

Zhen Xiao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138537 - 138537

Опубликована: Дек. 9, 2024

Язык: Английский

Процитировано

1
Research progress of ferroptosis in brain injury DOI
Yi Cao

Deleted Journal, Год журнала: 2024, Номер unknown, С. 1 - 14

Опубликована: Ноя. 10, 2024

Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation, has emerged as key contributor to neuronal damage in various types brain injury, including traumatic injury (TBI) and ischemic caused brian ischemia (BI). This review summarizes the underlying mechanisms ferroptosis injuries highlights its role exacerbating loss, inflammation, secondary damage. After TBI, release free iron oxidative stress after triggers ferroptosis, contributing long-term neurological deficits. Similarly, BI, is initiated accumulation reactive oxygen species (ROS) mitochondrial dysfunction during reperfusion, further amplifying The current provides comprehensive overview interplay between with an emphasis on potential targeting improve recovery outcomes patients. Future research directions include development novel inhibitors integration ferroptosis-targeting strategies existing treatment modalities.

Язык: Английский

Процитировано

0
Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action DOI Open Access
Manuela Malatesta,

Gabriele Tabaracci,

C. Pellicciari

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12657 - 12657

Опубликована: Ноя. 25, 2024

Ozone (O

Язык: Английский

Процитировано

0