Chrysanthemum morifolium attenuates metabolic and alcohol-associated liver disease via gut microbiota and PPARα/γ activation
Phytomedicine,
Год журнала:
2024,
Номер
130, С. 155774 - 155774
Опубликована: Май 23, 2024
Язык: Английский
Mechanism of anti-hepatitis potential of Tagetes erecta L: UPLC-Q-TOF-M S/MS, network pharmacology, molecular docking and in vitro experimental validation
Next research.,
Год журнала:
2025,
Номер
unknown, С. 100169 - 100169
Опубликована: Янв. 1, 2025
Язык: Английский
Comparative Analysis of the Chemical Constituents of Chrysanthemum morifolium with Different Drying Processes Integrating LC/GC–MS−Based, Non-Targeted Metabolomics
Na Chen,
Jizhou Fan,
Gang Li
и другие.
Metabolites,
Год журнала:
2024,
Номер
14(9), С. 481 - 481
Опубликована: Сен. 2, 2024
is
a
perennial
herbaceous
plant
in
the
Asteraceae
family
that
used
as
medicine
and
food
owing
to
its
superior
pharmacological
properties.
Irrespective
of
application,
Язык: Английский
Metabolomics Combined with Network Pharmacology to Explore the Active Components and Mechanism of Tetrastigma planicaule (Hook.) Gagnep. in the Treatment of Rheumatoid Arthritis
Journal of Chemistry,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Context
.
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
inflammatory
disease.
It
characterized
by
persistent
joint
damage.
Traditional
Chinese
medicine
(TCM)
has
demonstrated
notable
efficacy
in
managing
RA.
Prior
investigations
have
indicated
that
the
ethyl
acetate
extract
of
Tetrastigma
planicaule
(Hook.)
Gagnep.
(TP)
possesses
substantial
anti‐inflammatory
properties,
suggesting
potential
for
screening
TCM
drugs
with
antirheumatoid
attributes.
However,
precise
mechanism
underlying
its
pharmacological
effects
and
material
basis
remains
unclear,
impeding
advancement
innovation.
Objective
This
study
to
elucidate
active
components
TP
treatment
Materials
Methods
A
rat
model
collagen‐induced
(CIA)
was
established
conducting
experiments
assess
effectiveness
from
treating
In
addition,
nuclear
magnetic
resonance
(NMR)
metabolomics
technology
employed
identify
endogenous
biomarkers
further
metabolic
pathway
analysis.
The
compounds
key
targets
were
investigated
using
ultraperformance
liquid
chromatography‐quadrupole
time‐of‐flight
mass
spectrometry
(UPLC‐Q‐TOF‐MS/MS)
combination
network
pharmacology.
Moreover,
common
gene
discovered
pharmacology
validated
molecular
docking
relevant
components.
Result
12
screened
1H‐NMR
technology.
metabolite
pathways
are
primarily
implicated
lipid
metabolism
amino
acid
metabolism.
49
identified
TP,
which
10
considered
ingredients
through
comprehensive
analysis,
it
found
exhibited
strong
association
PLA2G4A
Molecular
studies
high
affinity
between
PLA2G4A.
Discussion
Conclusions
may
play
therapeutic
role
RA
regulating
participating
back‐regulating
glycerophospholipid
pathway.
elucidated
multicomponent,
multitarget,
multipathway
RA,
laying
groundwork
deeper
understanding
mechanisms.
Язык: Английский
Cytotoxic Potential of Integrative Medicinal Plant on <i>Chrysanthemum Indicum</i> Flower Extract
G. A. Palanisamy,
Farshid,
Dinesh Kumar S
и другие.
The Indian Journal of Nutrition and Dietetics,
Год журнала:
2024,
Номер
unknown, С. 310 - 327
Опубликована: Авг. 6, 2024
In
the
present
study,
plant
extract
and
CuO
nanoparticles
were
synthesized
by
simple
green
method
using
Chrysanthemum
indicum
flower.
Plant
investigate
for
their
secondary
metabolites
antioxidant
activity
NPs
UV,
FTIR
anticancer
activity.
Flower
sample
of
collected,
air-
dired,
pulverized
subjected
to
extraction
with
water
as
a
solvent.
The
total
phenol,
flavonoids
tannin
content,
aqueous
evaluated
DPPH,
hydroxyl
radicles,
nitric
oxide
SOD
assay.
characterization
cytotoxic
potential
activity,
respectively.
content
found
be
insignificant
amount
bioactive
compounds
present.
Nitric
assay
revealed
that
exhibited
strong
UV
studies
demonstrated
formation
synthesis
extract.
cytotoxicity
study
reveals
plants
are
nontoxic
PC
cell
line.
Study
concluded
leaves
rich
source
phytochemicals.
Based
on
preliminary
investigation,
further
research
should
focused
isolate
phytochemicals
leading
clinical
medicine
in
future.
Язык: Английский