ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(48), С. 55201 - 55231
Опубликована: Ноя. 23, 2023
The
nanomaterial
and
related
toolkit
have
promising
applications
for
improving
human
health
well-being.
Nanobased
drug
delivery
systems
use
nanoscale
materials
as
carriers
to
deliver
therapeutic
agents
in
a
targeted
controlled
manner,
they
shown
potential
address
issues
associated
with
conventional
systems.
They
offer
benefits
treating
various
illnesses
by
encapsulating
or
conjugating
biological
agents,
chemotherapeutic
drugs,
immunotherapeutic
agents.
of
this
technology
are
vast;
however,
significant
challenges
exist
overcome
such
safety
issues,
toxicity,
efficacy,
insufficient
capacity.
This
article
discusses
the
latest
developments
systems,
including
release
mechanisms,
material
toolkits,
design
molecules,
parameters.
concluding
section
examines
limitations
provides
insights
into
future
possibilities.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Polymers,
Год журнала:
2024,
Номер
16(4), С. 504 - 504
Опубликована: Фев. 12, 2024
In
the
21st
century,
chemotherapy
stands
as
a
primary
treatment
method
for
prevalent
diseases,
yet
drug
resistance
remains
pressing
challenge.
Utilizing
electrospinning
to
support
drugs
offers
sustained
and
controlled
release
methods
in
contrast
oral
implantable
delivery
modes,
which
enable
localized
of
distinct
tumor
types.
Moreover,
core–sheath
structure
bears
advantages
dual-drug
loading:
core
sheath
layers
can
carry
different
drugs,
facilitating
collaborative
counter
resistance.
This
approach
minimizes
patient
discomfort
associated
with
multiple-drug
administration.
Electrospun
fibers
not
only
transport
but
also
integrate
metal
particles
targeted
compounds,
enabling
combinations
magnetic
heat
therapies
comprehensive
cancer
treatment.
review
delves
into
preparation
techniques
tailored
various
cancers,
foreseeing
their
promising
roles
Polymers,
Год журнала:
2023,
Номер
15(9), С. 2028 - 2028
Опубликована: Апрель 25, 2023
Polymers
have
been
widely
used
for
the
development
of
drug
delivery
systems
accommodating
regulated
release
therapeutic
agents
in
consistent
doses
over
a
long
period,
cyclic
dosing,
and
adjustable
both
hydrophobic
hydrophilic
drugs.
Nowadays,
polymer
blends
are
increasingly
employed
as
they
generate
more
promising
results
when
compared
to
those
homopolymers.
This
review
article
describes
recent
research
efforts
focusing
on
utilization
chitosan
with
other
polymers
an
attempt
enhance
properties
chitosan.
Furthermore,
various
applications
thoroughly
discussed
herein.
The
literature
from
past
ten
years
was
collected
using
search
engines
such
ScienceDirect,
J-Gate,
Google
Scholar,
PubMed,
data
were
compiled
according
novel
carrier
systems.
Nanocarriers
made
derivatives
positive
surface
charge,
which
allows
control
rate,
duration,
location
body,
can
increase
safety
efficacy
system.
Recently
developed
nanocarriers
shown
be
cost-effective,
efficacious,
prolonged
carriers
that
incorporated
into
suitable
dosage
forms.
Journal of Energy Storage,
Год журнала:
2023,
Номер
68, С. 107660 - 107660
Опубликована: Май 17, 2023
This
study
aimed
to
introduce
a
smart
multifunctional
textile
composed
of
phase
change
material,
i.e.,
polyethylene
glycol
(PEG),
with
potential
for
thermo-regulative
biomedical
application.
PEG
was
efficiently
form-stabilized
polycaprolactone,
and
the
nanofibers
mats
were
developed
by
electrospinning
overcome
leakage
issue
during
process.
Gelatin
curcumin
also
incorporated
enable
performance
textiles.
The
results
revealed
that
electrospun
possessed
randomly
oriented
morphology,
sufficient
water
absorption
capability,
good
mechanical
properties,
excellent
performance.
fibers'
diameter
varied
from
220
nm
370
nm,
tensile
strength
ranging
10
30
MPa.
Furthermore,
fabricated
latent
heat
61.7
J/g
reliable
energy
absorption-release
cyclability
over
100
heating-cooling
cycles.
curcumin-loaded
textiles
an
initial
burst
release
followed
sustained
one
week.
They
further
presented
significant
antioxidant
activity
81.23.7
±
3.08
%
after
24
h,
introducing
great
application
as
dressing
diminish
inflammation
cooling
effect.
