Enhanced cytotoxicity of exo- and endogenous compounds by hitchhiking lipid-based nanocarriers

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106628 - 106628

Опубликована: Янв. 1, 2025

Язык: Английский

---

Comparative Analysis of PEG‐Free and PEG‐Based Self‐Emulsifying Drug Delivery Systems for Enhanced Oral Bioavailability of Therapeutic (Poly) Peptides

Small, Год журнала: 2024, Номер 20(27)

Опубликована: Фев. 2, 2024

Abstract This study aims to compare the potential of Polyethylene glycol (PEG‐free and PEG‐based self‐emulsifying drug delivery systems (SEDDS) for oral administration insulin glargine (IG). Hydrophobic ion pairs (HIPs) IG are formed using various counterions. HIPs assessed log P octanol/water dissociation behavior. They incorporated into SEDDS based on polyglycerol (PG) zwitterionic surfactant (ZW) response surface methodology compared conventional PEG‐SEDDS in size, stability, D SEDDS/release medium . Oral bioavailability PG/ZW‐SEDDS is evaluated rats. Among counterions studied, IG‐BIS (bis(isotridecyl)sulfosuccinate) demonstrated highest an improved profile. have similar ≈40 nm sizes stable over 24 h. Both formulations > 4 water >2 50 mM phosphate buffer pH 6.8. yielded 2.13 ± 0.66% IG, while employment resulted 1.15 0.35%. highlights prospective utilization PEG‐free involving concurrent application PG ZW surfactants, alternative PEG therapeutic (poly) peptide delivery.

Язык: Английский

---

Oral formulations for highly lipophilic drugs: Impact of surface decoration on the efficacy of self-emulsifying drug delivery systems

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 677, С. 1108 - 1119

Опубликована: Июль 31, 2024

To evaluate the impact of surface decoration cannabidiol (CBD) loaded self-emulsifying drug delivery systems (SEDDS) on efficacy formulations to cross various barriers faced by orally administered drugs.

Язык: Английский

---

Optimizing hydrophilic drug incorporation into SEDDS using dry reverse micelles: a comparative study of preparation methods

Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

---

Recent Advancements in the Development of Nanocarriers for Mucosal Drug Delivery Systems to Control Oral Absorption

Pharmaceutics, Год журнала: 2023, Номер 15(12), С. 2708 - 2708

Опубликована: Ноя. 30, 2023

Oral administration of active pharmaceutical ingredients is desirable because it easy, safe, painless, and can be performed by patients, resulting in good medication adherence. The mucus layer the gastrointestinal (GI) tract generally acts as a barrier to protect epithelial membrane from foreign substances; however, absorption process after oral administration, also disturb effective drug trapping biological sieve structured mucin, major component mucus, eliminating turnover. Recently, functional nanocarriers (NCs) have attracted much attention due their immense potential effectiveness field delivery. Among them, NCs with mucopenetrating mucoadhesive properties are promising dosage options for controlling GI tracts. Mucopenetrating rapidly deliver encapsulated drugs site and/or prolong residence time close membrane, providing better medications than conventional approaches. surface characteristics important factors that determine functionality, owing formation various kinds interactions between particle mucosal components. Thus, deeper understanding modifications on biopharmaceutical necessary develop appropriate delivery systems (mDDS) treatment target diseases. This review summarizes basic information functions layer, highlights recent progress designing mDDS, discusses performance tract.

Язык: Английский

---

Optimizing the Structure of a Pt Metal-Chelating Polymer to Reduce Nonspecific Binding for Mass Cytometry

Biomacromolecules, Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Mass cytometry is a bioanalytic tool based on atomic mass spectrometry for detecting biomarker expression individual cells. Current reagents employ metal-chelating polymers binding isotopes of hard metal ions. Polymers bearing chelators soft ions offer the promise large increase in multiplexing capabilities, but examples reported so far often have unacceptably high levels nonspecific (NSB). We recently new class with dipicolylamine (DPA) that could bind Re and Pt. They also showed significant NSB. Here, to reduce NSB Pt-DPA polymer, we grafted water-soluble oligomers distal end pendant group. Methoxy(polyethylene glycol) (DP = 24) was effective as poly(sulfobetaine methacrylate) 29). Reacting Pt-Cl bond metalated polymer glutathione remarkably at suppressing These results open door Pt-isotope-based tags cytometry.

Язык: Английский

---

Ultrastable and Redispersible Zwitterionic Bottlebrush Micelles for Drug Delivery

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Bottlebrush copolymers are increasingly used for drug delivery and biological imaging applications in part due to the enhanced thermodynamic stability of their self-assemblies. Herein, we discuss effect hydrophilic block chemistry on bottlebrush micelles. Amphiphilic bottlebrushes with zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) nonionic polyethylene glycol (PEG) blocks were synthesized by "grafting from" polymerization self-assembled into well-defined spherical Colloidal against disassembly challenged under high concentrations NaCl, MgSO

Язык: Английский

---

Zwitterionic lipid nanoparticles for efficient siRNA delivery and hypercholesterolemia therapy with rational charge self-transformation

Theranostics, Год журнала: 2025, Номер 15(8), С. 3693 - 3712

Опубликована: Март 1, 2025

Rationale: Effective delivery of small interfering RNA (siRNA) remains a significant challenge in treating hypercholesterolemia due to biocompatibility, cellular uptake, and endosomal escape issues. Rational regulation carrier surface charge contributes efficient siRNA vivo. Methods: This study introduces zwitterionic lipid nanoparticles (ZwiLNPs) as novel solution these challenges. By leveraging the unique properties polymers, we achieved robust encapsulation targeted delivery. The design ZwiLNPs facilitates self-transformation response physiological conditions, which enhances their biocompatibility uptake efficiency. Result: In vivo studies demonstrated liver-targeting capabilities ZwiLNPs, with improved following internalization. Comparative analyses confirmed that outperform conventional terms both release. Conclusion: These findings position promising platform for interference therapies, particularly other lipid-related disorders.

Язык: Английский

---

Boronic acid-mediated mucin/surface interactions of zwitterionic polymer brushes

Soft Matter, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Mucus is a substance that acts as protective barrier, shielding tissues from infections caused by viruses and bacteria. Recent studies highlight the advantages of transmucosal drug delivery compared to traditional methods. However, external particles in mucus struggle penetrate its deeper layers are often eliminated clearance mechanisms, hindering effective delivery. To gain understanding how material surfaces interact with mucus, we grafted brushes poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) onto silica surfaces, followed straightforward installation terminal boronic acid moiety (3-phenylboronic acid, APBA). The modification process was carried out following surface-initiated activator regenerated electron transfer atom radical polymerization (SI-ARGET ATRP), method known for effectiveness producing well-defined polymers. After conjugation APBA, studied effects surface chemistry on properties such pH-sensitivity mucin adsorption. modified zwitterionic polymer showed no interaction regardless system pH. all containing acid-sialic interactions, particularly at lower pH values. insights gained this study will enhance our interactions between PMPC APBA mucins, laying groundwork future chemical modifications particle aimed modulating their transport through mucus.

Язык: Английский

---

Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113677 - 113677

Опубликована: Апрель 1, 2025

Oral delivery of the proliferation-inhibiting brain acid-soluble protein 1 effector domain peptide (Myr-NT) towards MYC-dependent gastrointestinal tumors can be achieved by forming hydrophobic ion pairs (HIPs) and incorporating them into lipid-based formulations. Hydrophobic pairing fluorescently-labelled Myr-NT (Myr-NT-TAMRA) was performed, increase in lipophilicity assessed, most promising HIP subsequently incorporated a nanoemulsion. Stability degradation trypsin evaluated. Anti-proliferative anti-invasive measurements were performed upon application loaded nanoemulsion on various human cancer cell lines. Cellular uptake molecular effect complementary investigated confocal laser scanning microscopy (CLSM) immunoblot analyses, respectively. HIPs Myr-NT-TAMRA exhibited up to 10,000-fold lipophilicity, thereby enabling incorporation The formulation significantly boosted stability enzymatic trypsin. Furthermore, anti-proliferative lines revealed superior biological activity compared native particularly lymphoma cells, but also colorectal cells. Thereby, correlation with proliferation inhibition as well differences MYC expression observed. Finally, CLSM imaging 15-fold increased cellular from confirming efficient intracellular peptide. efficiently delivered intestinal tumor cells using orally administered

Язык: Английский

---