RSC Advances,
Год журнала:
2024,
Номер
14(53), С. 39163 - 39172
Опубликована: Янв. 1, 2024
The
flexible
design
and
unique
physical
chemical
properties
of
self-assembled
peptides
have
shown
great
potential
for
applications
in
the
fields
materials
science,
life
environmental
science.
Peptide
nanofibers
(PNFs),
as
a
kind
bioactive
nanomaterials,
possess
excellent
biocompatibility,
designability,
multifaceted
functionalizability.
In
this
work,
we
describe
PNFs
that
by
peptide
molecules
carriers
bimetallic
nanosheets
(BMNS),
leading
to
development
hybrid
BMNS-PNFs,
with
properties.
BMNS-PNFs
exhibit
photothermal
conversion
efficiency
(PCE)
up
31.57%,
can
be
used
nanoplatform
therapy
(PTT)
lung
tumour
cells.
Through
results,
it
is
reduce
cytotoxicity
cancer
cell
killing
effects,
rates
more
than
95%
90%
cells
HCC2279
PC9,
respectively.
Finally,
comprehensive
PTT
performance
analysed
Ranking
Efficiency
Performance
(REP),
REP
value
calculated
0.741.
sequences
assemble
into
study
are
instructive
functional
structural
modulation
molecular
self-assembly,
constructed
bimetallic-biomolecular
provide
strategy
medical
bioengineering.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Metastasis
is
the
leading
cause
of
death
in
patients
with
lung
cancer.
Multidisciplinary
comprehensive
treatments
(MDT),
including
surgery,
chemotherapy,
radiotherapy,
gene-targeted
therapy,
immunotherapy,
antibody-drug
conjugate
(ADC),
natural
products,
etc.,
have
been
currently
used
for
cancer
metastasis.
The
MDT
model
has
shown
promising
efficacy
against
metastasis
clinical
practice.
However,
these
therapies
some
limitations,
such
as
unusual
toxic
side
effects,
drug
resistance,
limited
indications,
and
high
costs.
Therefore,
emerging
technological
platforms
are
imperative
to
overcome
bottlenecks.
Nanomedicine
can
be
prepare
efficient
delivery
systems
owing
its
good
biocompatibility,
targeting,
responsive
release,
multidrug
codelivery
plays
an
important
role
synergistic
antimetastasis
because
optical,
acoustic,
electrical,
thermal,
magnetic
functions.
This
review
analyses
limitations
model,
briefly
outlines
advantages
nanotechnology,
introduces
nanodrug
systems,
summarizes
nanostrategies
based
on
invasion-metastasis
cascade
process,
provides
a
summary
prospects
challenges
translation
nanomedicines.
ABSTRACT
The
increasing
emergence
of
antimicrobial
resistance
and
the
development
new
infective
viral
strains
represent
a
constantly
growing
threat.
Metal‐based
nanomaterials
have
emerged
as
promising
tools
in
fight
against
bacterial
infections;
however,
release
metal
nanoparticles/ions
clinical
applications
may
cause
undesired
side
effects
(allergies,
systemic
toxicity),
reducing
their
practical
use
treatment.
Moreover,
metal‐based
nanoparticles
possess
predominantly
antibacterial
effects,
while
antiviral
efficiency
remains
controversial.
Thus,
metal‐free
strategies
enabling
combined
antibacterial/antiviral
properties
is
significant
challenge.
Here,
we
report
strategy
based
on
light
irradiation
nitrogen‐doped
graphene
acid
(NGA)
possessing
dual
photothermal
photodynamic
modes
action.
activity
activated
through
clinically
approved
near‐infrared
(NIR)
source,
both
spreading
can
be
hampered
coating
scale
minutes
(5
to
10
min).
developed
reduced
90.9%
99.99%
for
S.
aureus
P.
aeruginosa
,
respectively,
well
99.97%
murine
hepatitis
virus.
Importantly,
this
research
represents
advancement
safe,
metal‐free,
effective
treatments.
NGA
coatings
are
safe
skin,
showing
no
sensitization
or
irritation,
offer
potential
advanced
Current Medicinal Chemistry,
Год журнала:
2024,
Номер
31(27), С. 4320 - 4339
Опубликована: Март 29, 2024
Nanoparticles
have
been
crucial
in
redesigning
tumour
eradication
techniques,
and
recent
advances
cancer
research
accelerated
the
creation
integration
of
multifunctional
nanostructures.
In
fight
against
treatment
resistance,
which
has
reduced
effectiveness
traditional
radiation
chemotherapy,
this
paradigm
change
is
utmost
importance.
Graphene
oxide
(GO)
one
several
nanoparticles
made
carbon
that
a
splash
medical
field.
It
offers
potential
new
ways
to
treat
thanks
its
nanostructures,
can
precisely
transfer
genetic
elements
therapeutic
chemicals
areas.
Encapsulating
genes,
protecting
them
from
degradation,
promoting
effective
uptake
by
cells
are
two
GO
nanostructures'
greatest
strengths,
addition
improving
drug
pharmacokinetics
bioavailability
concentrating
compounds
at
particular
regions.
addition,
photodynamic
(PDT)
photothermal
therapy
(PTT),
use
reduce
carcinogenesis,
greatly
slowed
growth
due
GO's
phototherapy
capabilities.
their
uses,
attractive
vaccine
candidates
ability
stimulate
cellular
innate
immunity.
These
be
used
detect,
diagnose,
eradicate
because
they
respond
certain
stimuli.
The
numerous
advantages
for
attributed
large
part
primary
route
internalisation
through
endocytosis,
guarantees
accurate
delivery
target
locations.
revolutionary
nanostructures
highlighted
extensive
compendium
examines
current
oncological
breakthroughs.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Abstract
Bone
defects
arising
from
trauma
and
tumors
present
a
potential
risk
of
infection
compromise
host
immune
function.
Within
dysfunctional
microenvironment,
the
uncontrolled
breeding
bacteria
persistent
chronic
inflammation
exacerbate
bone
loss,
impeding
regeneration
repair.
Macrophages
function
as
specialized
phagocytes
within
microenvironment
orchestrated
role
distinct
phenotypes
during
has
attracted
significant
attention.
The
M1
phenotype
exhibits
antimicrobial
activities
to
eliminate
bacterial
threats,
while
M2
secretes
anti‐inflammatory
mediators
fine‐tune
microenvironment.
Here,
biphasic
delivery
system
consisting
photothermal
agent
(graphene
oxide,
GO)
coated
an
modulator
(urolithin
A,
UA)
encapsulated
in
coaxial
electrospun
nanofibers
with
dynamic
regulation
macrophage
behavior
is
designed.
It
observed
that
GO
coating
exhibited
remarkable
performance
near‐infrared
window,
affecting
phagocytic
activity
subsets
integrin‐RhoA‐ROCK1
dependent
manner.
sustained
release
UA
core
layer
induced
phenotypic
switch
by
downregulating
TNF
signaling
upregulating
TGF
signaling.
This
also
demonstrated
promotion
vivo.
Overall,
this
strategy
achieved
sequential
phenotypes,
effectively
preventing
fostering
tissue
regeneration.
