Biomimetic CuCoO2 nanosheets reinforced with self-assembling peptide nanofibers for tumor photothermal therapy DOI Creative Commons
Mingjin Xu,

Youyin Xu,

Chenxi Du

и другие.

RSC Advances, Год журнала: 2024, Номер 14(53), С. 39163 - 39172

Опубликована: Янв. 1, 2024

The flexible design and unique physical chemical properties of self-assembled peptides have shown great potential for applications in the fields materials science, life environmental science. Peptide nanofibers (PNFs), as a kind bioactive nanomaterials, possess excellent biocompatibility, designability, multifaceted functionalizability. In this work, we describe PNFs that by peptide molecules carriers bimetallic nanosheets (BMNS), leading to development hybrid BMNS-PNFs, with properties. BMNS-PNFs exhibit photothermal conversion efficiency (PCE) up 31.57%, can be used nanoplatform therapy (PTT) lung tumour cells. Through results, it is reduce cytotoxicity cancer cell killing effects, rates more than 95% 90% cells HCC2279 PC9, respectively. Finally, comprehensive PTT performance analysed Ranking Efficiency Performance (REP), REP value calculated 0.741. sequences assemble into study are instructive functional structural modulation molecular self-assembly, constructed bimetallic-biomolecular provide strategy medical bioengineering.

Язык: Английский

From the clinical perspective of photodynamic therapy and photothermal Therapy: Structure-Activity-Practice DOI
Lixin Lv,

Baolei Fan,

Xinrui Ji

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 507, С. 215733 - 215733

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

25

Nanomaterials-based advanced systems for photothermal / photodynamic therapy of oral cancer DOI
Yue Wang, Lili Chang, Hongyu Gao

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 272, С. 116508 - 116508

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

17

2D nanomaterials-based delivery systems and their potentials in anticancer synergistic photo-immunotherapy DOI

Yankun Luo,

Ming Chen, Ting Zhang

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 242, С. 114074 - 114074

Опубликована: Июль 4, 2024

Язык: Английский

Процитировано

4

Albumin as a functional carrier enhances solubilization, photodynamic and photothermal antibacterial therapy of curcumin DOI

Xuyang Lai,

J.C. Qiao, Jianhong Liu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140759 - 140759

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

0

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies DOI Creative Commons
Fan Xu, Yao Liu, Zujun Que

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Metastasis is the leading cause of death in patients with lung cancer. Multidisciplinary comprehensive treatments (MDT), including surgery, chemotherapy, radiotherapy, gene-targeted therapy, immunotherapy, antibody-drug conjugate (ADC), natural products, etc., have been currently used for cancer metastasis. The MDT model has shown promising efficacy against metastasis clinical practice. However, these therapies some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. Therefore, emerging technological platforms are imperative to overcome bottlenecks. Nanomedicine can be prepare efficient delivery systems owing its good biocompatibility, targeting, responsive release, multidrug codelivery plays an important role synergistic antimetastasis because optical, acoustic, electrical, thermal, magnetic functions. This review analyses limitations model, briefly outlines advantages nanotechnology, introduces nanodrug systems, summarizes nanostrategies based on invasion-metastasis cascade process, provides a summary prospects challenges translation nanomedicines.

Язык: Английский

Процитировано

0

Light Irradiation of N‐Doped Graphene Acid: Metal‐Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action DOI Creative Commons
Giacomo Reina, David Panáček,

Krista Rathammer

и другие.

EcoMat, Год журнала: 2025, Номер 7(4)

Опубликована: Март 26, 2025

ABSTRACT The increasing emergence of antimicrobial resistance and the development new infective viral strains represent a constantly growing threat. Metal‐based nanomaterials have emerged as promising tools in fight against bacterial infections; however, release metal nanoparticles/ions clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use treatment. Moreover, metal‐based nanoparticles possess predominantly antibacterial effects, while antiviral efficiency remains controversial. Thus, metal‐free strategies enabling combined antibacterial/antiviral properties is significant challenge. Here, we report strategy based on light irradiation nitrogen‐doped graphene acid (NGA) possessing dual photothermal photodynamic modes action. activity activated through clinically approved near‐infrared (NIR) source, both spreading can be hampered coating scale minutes (5 to 10 min). developed reduced 90.9% 99.99% for S. aureus P. aeruginosa , respectively, well 99.97% murine hepatitis virus. Importantly, this research represents advancement safe, metal‐free, effective treatments. NGA coatings are safe skin, showing no sensitization or irritation, offer potential advanced

Язык: Английский

Процитировано

0

Development of Graphene-Based Materials with the Targeted Action for Cancer Theranostics DOI Creative Commons
Konstantin N. Semenov, Olga S. Shemchuk, Sergei V. Ageev

и другие.

Biochemistry (Moscow), Год журнала: 2024, Номер 89(8), С. 1362 - 1391

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

2

Cationic liposomes as a drug-free system for efficient anticancer therapy by intracytoplasmic delivery of sodium bicarbonate DOI

Xiaotong Yu,

Mengying Xia, Yuan-Hong Li

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 240, С. 113984 - 113984

Опубликована: Май 22, 2024

Язык: Английский

Процитировано

2

The Application of Graphene Oxide Nanoarchitectures in the Treatment of Cancer: Phototherapy, Immunotherapy, and the Development of Vaccines DOI
Sankha Bhattacharya, Sateesh Belemkar, Bhupendra G. Prajapati

и другие.

Current Medicinal Chemistry, Год журнала: 2024, Номер 31(27), С. 4320 - 4339

Опубликована: Март 29, 2024

Nanoparticles have been crucial in redesigning tumour eradication techniques, and recent advances cancer research accelerated the creation integration of multifunctional nanostructures. In fight against treatment resistance, which has reduced effectiveness traditional radiation chemotherapy, this paradigm change is utmost importance. Graphene oxide (GO) one several nanoparticles made carbon that a splash medical field. It offers potential new ways to treat thanks its nanostructures, can precisely transfer genetic elements therapeutic chemicals areas. Encapsulating genes, protecting them from degradation, promoting effective uptake by cells are two GO nanostructures' greatest strengths, addition improving drug pharmacokinetics bioavailability concentrating compounds at particular regions. addition, photodynamic (PDT) photothermal therapy (PTT), use reduce carcinogenesis, greatly slowed growth due GO's phototherapy capabilities. their uses, attractive vaccine candidates ability stimulate cellular innate immunity. These be used detect, diagnose, eradicate because they respond certain stimuli. The numerous advantages for attributed large part primary route internalisation through endocytosis, guarantees accurate delivery target locations. revolutionary nanostructures highlighted extensive compendium examines current oncological breakthroughs.

Язык: Английский

Процитировано

1

Rational Design of Engineered Bionic Periosteum for Dynamic Immunoinduction, Smart Bactericidal, and Efficient Bone Regeneration DOI Open Access
Lei Yu, Yusen Qiao, Gaoran Ge

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Abstract Bone defects arising from trauma and tumors present a potential risk of infection compromise host immune function. Within dysfunctional microenvironment, the uncontrolled breeding bacteria persistent chronic inflammation exacerbate bone loss, impeding regeneration repair. Macrophages function as specialized phagocytes within microenvironment orchestrated role distinct phenotypes during has attracted significant attention. The M1 phenotype exhibits antimicrobial activities to eliminate bacterial threats, while M2 secretes anti‐inflammatory mediators fine‐tune microenvironment. Here, biphasic delivery system consisting photothermal agent (graphene oxide, GO) coated an modulator (urolithin A, UA) encapsulated in coaxial electrospun nanofibers with dynamic regulation macrophage behavior is designed. It observed that GO coating exhibited remarkable performance near‐infrared window, affecting phagocytic activity subsets integrin‐RhoA‐ROCK1 dependent manner. sustained release UA core layer induced phenotypic switch by downregulating TNF signaling upregulating TGF signaling. This also demonstrated promotion vivo. Overall, this strategy achieved sequential phenotypes, effectively preventing fostering tissue regeneration.

Язык: Английский

Процитировано

1