Light-Responsive Functional Nanomaterials as Pioneering Therapeutics: A Paradigm Shift to Combat Age-Related Disorders

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(34), С. 8212 - 8234

Опубликована: Янв. 1, 2024

Aging, marked by dysregulated cellular systems, gives rise to a spectrum of age-related disorders, including neurodegeneration, atherosclerosis, immunosenescence, and musculoskeletal issues. These conditions contribute significantly the global disease burden, posing challenges health span economic resources. Current therapeutic approaches, although diverse in mechanism, often fall short targeting underlying pathologies. They fail address issues compounded altered pharmacokinetics elderly. Nanotechnology emerges as transformative solution, offering tissue-specific targeted therapies through nanoparticles. Functional nanomaterials (FNMs) respond internal or external stimuli, with light-responsive gaining prominence. Harnessing benefits deep tissue penetration ease manipulation particularly near-infrared spectrum, FNMs present innovative strategies for comorbidities. This review comprehensively summarizes potential FNM-based approaches environments also emphasizes advantages over traditional treatment modalities. Specifically, it focuses on development various classes functional plasmonic nanomaterials, carriers, upconversion 2D transition metal oxide dichalcogenide carbon-based against age related diseases. We foresee that such advanced developments field nanotechnology could provide new hope clinical diagnosis disorders.

Язык: Английский

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Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Янв. 29, 2025

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at target site to catalyze production reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy PDT depends on PSs, amount oxygen, intensity excitation laser. PSs have been extensively researched, great efforts made develop an ideal photosensitizer. Chlorin-e6 is FDA-approved second-generation that has attracted widespread research interest medical field, especially with respect antitumor anti-inflammatory activity. possesses advantages a large absorption coefficient, high strength, low residue body, relatively safety thus promising application prospects. Here we review use chlorin-e6 discuss prospects further development this technology.

Язык: Английский

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Pr3+ Visible to Ultraviolet Upconversion for Antimicrobial Applications

Nanomaterials, Год журнала: 2025, Номер 15(7), С. 562 - 562

Опубликована: Апрель 6, 2025

This paper addresses the upconversion of blue light to ultraviolet-C (UVC) with Pr3+-activated materials for antibacterial applications UVC. It discusses processes through which UV radiation provides biocidal effects on microorganisms, along most popular UVC sources employed in these processes. We describe electronic and optical properties Pr3+ ion, emphasizing conditions host material must meet obtain broad intense emission from parity-allowed transitions 4f5d levels provide a list that fulfill conditions. also delineates lanthanide-based upconversion, focusing via 3P0 1D2 intermediate states, suggests routes improving quantum efficiency process. review literature related use antimicrobial photodynamic treatments germicidal effects. Further, we propose spectral overlap between effectiveness curve as criterion assessing potential applications. Finally, this briefly assesses toxicity commonly used preparation materials.

Язык: Английский

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Peptide-photosensitizer conjugates: From molecular design to function and antibacterial applications

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162723 - 162723

Опубликована: Апрель 1, 2025

Язык: Английский

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Construction of a novel fluorescent nanoenzyme based on lanthanides for tumor theranostics

Frontiers of Materials Science, Год журнала: 2024, Номер 18(4)

Опубликована: Окт. 2, 2024

Язык: Английский

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Recent Advances in Photodynamic Therapy in the Treatment of Dental Diseases

International Journal of Biology and Life Sciences, Год журнала: 2024, Номер 6(1), С. 44 - 47

Опубликована: Май 29, 2024

Photodynamic Therapy (PDT) is a new technology that utilizes the photodynamic effect for disease diagnosis and treatment. Its action based on effect. It kind of photosensitization reaction accompanied by biological effects with participation oxygen molecules. The process specific wavelength laser irradiation causes photosensitizer absorbed tissue to be excited, in excited state passes energy surrounding oxygen, generating highly reactive singlet which undergoes oxidative neighboring macromolecules produce cytotoxicity, leads cellular damage even death. Current research shows therapy great advantages treatment caries, periodontal oral squamous carcinoma. This paper mainly provides further overview current status at home abroad application dental diseases recent years.

Язык: Английский

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NIR responsive nanosystem based on upconversion nanoparticle-engineered bacteria for immune/photodynamic combined therapy with bacteria self-clearing capability

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 583 - 594

Опубликована: Сен. 20, 2024

Язык: Английский

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