Coordination Chemistry Reviews, Год журнала: 2024, Номер 526, С. 216348 - 216348
Опубликована: Дек. 2, 2024
Язык: Английский
Biology, Год журнала: 2025, Номер 14(2), С. 165 - 165
Опубликована: Фев. 6, 2025
Healthcare-associated infections pose a significant global health challenge, negatively impacting patient outcomes and burdening healthcare systems. A major contributing factor to healthcare-associated is the formation of biofilms, structured microbial communities encased in self-produced extracellular polymeric substance matrix. Biofilms are critical disease etiology antibiotic resistance, complicating treatment infection control efforts. Their inherent resistance mechanisms enable them withstand therapies, leading recurrent increased morbidity. This review explores development biofilms their dual roles disease. It highlights structural protective functions EPS matrix, which shields populations from immune responses antimicrobial agents. Key molecular biofilm including restricted penetration, persister cell dormancy, genetic adaptations, identified as barriers effective management. implicated various clinical contexts, chronic wounds, medical device-associated infections, oral complications, surgical site infections. prevalence hospital environments exacerbates challenges underscores urgent need for innovative preventive therapeutic strategies. evaluates cutting-edge approaches such DNase-mediated disruption, RNAIII-inhibiting peptides, DNABII proteins, bacteriophage nanoparticle-based solutions, coatings, lock therapies. also examines associated with biofilm-related diagnostic difficulties, disinfectant economic implications. emphasizes multidisciplinary approach importance understanding dynamics, role pathogenesis, advancements strategies combat biofilm-associated effectively settings. These insights aim enhance reduce burden diseases.
Язык: Английский
Процитировано
1
npj Biofilms and Microbiomes, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 14, 2024
Bacteriophages (phages), viruses capable of infecting and lysing bacteria, are a promising alternative for treating infections from hypervirulent, antibiotic-resistant pathogens like Klebsiella pneumoniae, though narrow host range phage resistance remain challenges. In this study, the hypervirulent K. pneumoniae NTUH-K2044 was used to purify ΦK2044, while two ΦK2044-resistant strains were further phages: ΦKR1, ΦKR8 hospital sewage. A detailed characterization showed that ΦK2044 specifically killed KL1 capsule-type ΦKR1 targeted 13 different capsular serotypes. The cocktail (ΦK2044 + ΦKR8) effectively in biofilms, pre-treatment biofilm formation, delayed phage-resistance. improved 7-day survival Galleria mellonella mouse models therapeutic potential catheter model. summary, proof-of-principle has broad range, including highly drug-resistant serves as starting point optimizing therapy.
Язык: Английский
Процитировано
7
Sensors, Год журнала: 2025, Номер 25(2), С. 585 - 585
Опубликована: Янв. 20, 2025
Fluorescent iron nanoclusters are emerging fluorescent nanomaterials. Herein, we synthesized hemoglobin-coated (Hb−Fe NCs) with a significant fluorescence emission peak at 615 nm and investigated the inner-filter effect of induced by manganese dioxide nanosheet (MnO2 NS). The quenching Hb−Fe NCs MnO2 NS can be significantly reversed addition ascorbic acid. On basis recovery acid, proposed system that consisted NCs, ascorbate phosphate, was successfully used for alkaline phosphatase (ALP) detection in range 0–20 μg/mL based on achieved.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136481 - 136481
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
2
Coordination Chemistry Reviews, Год журнала: 2024, Номер 526, С. 216348 - 216348
Опубликована: Дек. 2, 2024
Язык: Английский
Процитировано
1