Layer-by-Layer Multitargeting Strategy for Enhanced Photothermal Therapy
ACS Omega,
Год журнала:
2025,
Номер
10(6), С. 5460 - 5467
Опубликована: Фев. 8, 2025
Photothermal
therapy
(PTT)
presents
unique
advantages,
including
high
temporal
and
spatial
controllability
relatively
few
toxic
side
effects.
Active
targeting
modifications
of
photothermal
agents
can
deliver
nanoprobes
to
tumors
more
efficiently,
reducing
effects
while
improving
efficacy.
In
this
work,
the
polyphenols,
gallic
acid,
folic
acid
(FA),
hyaluronic
(HA),
Fe(III)
were
selected
prepare
a
self-photothermal
nanoplatform
Ga/Fe/HA/FA
based
on
polyphenol-metal
self-assembly.
The
self-assembly
process
synchronously
integrated
molecules,
layer
by
in
network,
thus
realizing
"layer-by-layer
targeting"
effect.
Compared
with
traditional
modification,
multitargeting
modification
strategy
effectively
avoided
complicated
experimental
steps
modification.
Meanwhile,
it
mitigated
off-target
risk
during
blood
circulation
improved
tumor-targeting
efficiency,
ultimately
augmenting
effectiveness
therapy.
Язык: Английский
Iron–Curcumin–Polyvinylpyrrolidone Nanoparticles With Dynamic Disassembly and Elimination Abilities for Photothermal/Chemo Combinatorial Therapy
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
ABSTRACT
Due
to
the
heterogeneity
of
tumor,
it
is
difficult
achieve
complete
ablation
tumor
by
single
photothermal
treatment.
Moreover,
their
broader
use
constrained
intrinsic
high
uptake
in
reticuloendothelial
system
(RES)
organs,
resulting
slow
elimination
from
body
and
potential
toxicity.
In
this
study,
we
report
a
single‐step
synthetic
approach
fabricate
versatile
FeCP‐NPs,
leveraging
coordination
bonds
formed
between
bioactive
polyphenolic
compounds
(curcumin),
Fe
III
ions,
polyvinyl
pyrrolidone
(PVP).
The
FeCP‐NPs
possess
following
favorable
characteristics:
(1)
components
originate
natural
products,
an
endogenous
element,
FDA‐approved
polymer,
guaranteeing
good
biosafety.
(2)
exhibit
excellent
properties.
(3)
After
treatment
completed,
dynamic
disassembly
strategy
triggered
deferoxamine
mesylate
(DFO)
can
induce
dissociation
nanoparticles
rapid
clearance
vivo.
(4)
Curcumin
released
during
be
combined
with
therapy
ablation.
A
comprehensive
analysis
safety,
biodistribution,
patterns
conducted
vitro
or
This
work
provides
nanoparticle
great
clinical
translational
new
solution
for
inhibiting
growth.
Язык: Английский
Drug Delivery Platform Targeting MMP9 in Combination with Photothermal Therapy to Improve Tumor Chemosensitivity
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Abstract
Tumor
chemotherapy
insensitivity
poses
a
significant
challenge
in
cancer
treatment,
with
angiogenesis
being
key
contributing
factor.
Angiogenesis
supplies
oxygen
and
nutrients
to
tumor
cells,
thereby
impairing
treatment
outcomes.
Based
on
these
findings,
an
MMP9‐responsive
carbon
quantum
dot‐based
nanoplatform
(MMP9i@MTX@CQDs)
encapsulating
methotrexate
(MTX)
MMP9
inhibitor
(MMP9i)
is
developed
overcome
insensitivity.
Targeting
the
high
expression
of
tumors,
platform
releases
its
payload
responsive
manner.
Under
near‐infrared
(NIR)
irradiation,
system
effectively
downregulated
angiogenesis‐related
molecules,
including
VEGF
CD31,
inhibited
Wnt/β‐catenin
signaling
pathway,
reversing
This
integrates
CQDs
MTX,
enabling
photothermal
therapy
(PTT)
inhibition,
offering
robust
safe
strategy
sensitize
tumors
chemotherapy.
Язык: Английский
Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application
Aggregate,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
ABSTRACT
The
field
of
molecular
charge
transfer
cocrystals
(CTCs)
has
advanced
rapidly
in
recent
years,
with
much
work
focused
on
their
use
optoelectronic
devices,
photoacoustic
imaging,
photothermal
therapy
(PTT),
optical
waveguides,
seawater
desalination,
and
more.
Organic
CTCs
are
particular
interest
because
unique
phototherapeutic
effects
phototherapy
remarkable
imaging
capabilities
fluorescence,
magnetic
resonance,
further
enhancing
significance
medical
applications.
However,
the
biomedicine
been
limited,
few
reported
biological
Hence,
there
is
a
growing
CT‐derived
functional
potential
contenders
for
targeted
controlled
biomedical
applications
such
as
bacteria
inhibition,
cancer
eradication,
tissue
regeneration.
This
review
offers
insight
into
advancements
crafting
producing
CT‐based
materials
attributes.
In
addition,
it
outlines
current
obstacles
future
prospects
this
burgeoning
research
domain,
aiming
to
propel
continued
advancement
biomaterials
toward
enhanced
utilities.
Overall,
cocrystal‐based
near‐infrared
(NIR)
have
revolutionize
wide
range
technological
an
active
area
chemistry,
science,
nanotechnology.
Язык: Английский
Vat Photopolymerization 3D Printing of Hydrogels Embedding Metal–Organic Frameworks for Photodynamic Antimicrobial Therapy
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(42), С. 57778 - 57791
Опубликована: Окт. 14, 2024
Given
the
variability
in
wounds
based
on
underlying
causes,
personalized
medicine
and
tailored
care
for
patients
with
are
required
to
ensure
optimal
therapeutic
outcomes.
With
emergence
of
high-precision
high-efficiency
photocuring
3D
printing
technology,
there
is
potential
its
use
customizing
precise
shapes
that
can
match
complex
wound
sites,
thereby
providing
better
treatment
infections.
In
this
work,
porphyrinic
metal–organic
framework
(MOF)
crystals,
serving
as
functional
filler,
were
incorporated
into
gelatin
methacrylate
(GelMA)
a
photocurable
composite
resin
investigate
capabilities
producing
customizable
dressings
through
vat
photopolymerization
printing.
The
embedded
MOF
crystals
allow
control
process
due
photon
competition
photoinitiator,
enabling
structures.
addition,
these
impart
photothermal
photodynamic
printed
object.
antibacterial
assay
confirms
potent
bactericidal
properties
GelMA/MOF
hydrogels.
hydrogel
highest
content
exhibited
over
99.99%
efficiency
against
both
Gram-positive
Staphylococcus
aureus
Gram-negative
Escherichia
coli
after
30
min
light
exposure
(∼30
mW/cm2,
λ
≥
420
nm).
Simultaneously,
hemolysis
cytotoxicity
evaluations
validated
their
excellent
biocompatibility.
findings
presented
here
introduce
strategy
integrating
photosensitive
fabricate
size-adjustable
photothermal/photodynamic
monoliths
patches,
opening
perspectives
toward
management.
Язык: Английский
Conjugated Human Serum Albumin/Gold-Silica Nanoparticles as Multifunctional Carrier of a Chemotherapeutic Drug
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13701 - 13701
Опубликована: Дек. 21, 2024
We
report
the
design
and
development
of
a
novel
multifunctional
nanostructure,
RB-AuSiO2_HSA-DOX,
where
tri-modal
cancer
treatment
strategies—photothermal
therapy
(PTT),
photodynamic
(PDT),
chemotherapy—luminescent
properties
targeting
are
integrated
into
same
scaffold.
It
consists
gold
core
with
optical
thermo-plasmonic
is
covered
by
silica
shell
entrapping
well-known
photosensitizer
luminophore,
Rose
Bengal
(RB).
The
nanoparticle
surface
was
decorated
Human
Serum
Albumin
(HSA)
through
covalent
conjugation
to
confer
its
abilities
as
carrier
Doxorubicin
(DOX),
one
most
effective
anticancer
drugs
in
clinical
chemotherapy.
obtained
nanostructure
fully
characterized
transmission
electron
microscopy
(TEM),
dynamic
light
scattering
(DLS)
UV-visible
spectroscopy,
homogeneous
spherical
shape,
an
average
diameter
about
60
nm
negative
ζ-potential
value
Singlet
oxygen
generation
photothermal
were
explored
under
green
irradiation.
interaction
between
DOX-HSA
anchored
on
nanoplatform
investigated
fluorescence
spectroscopy
compared
that
DOX-HSA,
pointing
out
different
accessibility
drug
molecules
HSA
binding
sites,
whether
protein
free
or
bound
surface.
To
best
our
knowledge,
there
no
studies
comparing
drug–HSA
nanoparticles.
Furthermore,
uptake
RB-AuSiO2_HSA-DOX
MDA-MB-231
mammary
cells
assessed
confocal
imaging,
highlighting—at
early
time
incubation
demonstrated
increased
DOX
luminescence
displayed
within
cells—a
better
internalization
carried
one,
making
suitable
promising
platform
for
multimodal
approach.
Язык: Английский