Current advances in nanozyme-based nanodynamic therapies for cancer

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Acute lung injury (ALI) refers to damage related cells, typically caused by an uncontrollable inflammatory response, and over‐generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, simple synthesis ultra‐small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities broad spectrum ROS scavenging, thereby promoting tissue repair ALI immunotherapy. Mechanistically, through therapeutic strategy TP@Pd+NIR, damaged cells tissues are ameliorated decreasing intracellular levels (total ROS, ·OH ·O 2 − ), downregulating cytokines (IL‐6, TNF‐α IL‐1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation iNOS CD86, upregulation IL‐10 CD206), activating immunoregulation (CD4 + /CD8 ratio increase), (upregulation HSP70 CD31), suppressing NF‐κB signaling pathway phosphorylated p65 IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated 6 h, indicating promising efficacy via this administration route. Notably, TP@Pd+NIR demonstrated excellent synergistic effects alleviating inflammation storms, reducing diffuse alveolar damage, accelerating repair. Summarily, work has designed a novel enhancement amelioration, which may serve as approach other diseases.

Язык: Английский

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Study on synergistic mechanism of Cu-TCPP@MnO2 composites for photothermal/photodynamic/chemodynamic treatment of infected wound healing

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162334 - 162334

Опубликована: Апрель 1, 2025

Язык: Английский

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Ultrasmall gold-encapsulated mesoporous platinum to promote photodynamic/catalytic therapy through cascade enzyme-like reactions

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 680, С. 117 - 128

Опубликована: Ноя. 3, 2024

Язык: Английский

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