Abstract
Staphylococcus
aureus
(
S.
)‐infected
osteomyelitis
is
a
deep
tissue
infection
that
cannot
be
effectively
treated
with
antibiotics.
Microwave
(MW)
thermal
therapy
(MTT)
and
MW
dynamic
(MDT)
based
on
MW‐responsive
materials
are
promising
for
the
of
bacteria‐infected
occurring
in
tissues
In
this
work,
system
carbon
nanotubes
(CNTs)/Prussian
blue
(PB)/puerarin
(Pue)
stable
network‐like
structures
constructed.
The
PB
grown
situ
CNTs,
its
introduction
not
only
reduces
aggregation
but
large
specific
surface
area
mesoporous
structure
can
also
provide
many
active
sites
adsorption
oxygen
polar
molecules.
Pue
natural
anti‐inflammatory
material
inflammation
at
site.
composite
CNTs
avoids
skin
effect
thus
improve
dielectric
reflection
losses.
response
CNTs/PB/Pue
mainly
due
to
occurrence
loss,
multiple
reflections
scattering,
interface
polarization,
dipole
polarization.
addition,
under
irradiation,
produce
reactive
species
(ROS),
such
as
singlet
1
O
2
),
hydroxyl
radical
(·OH).
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Nonhealing
chronic
bacterial
infections
are
very
challenging
to
both
patients
and
the
healthcare-providing
system.
Multimodal
therapy
enhances
antibiotic
efficacy
treat
via
combating
multidrug
resistance
through
cumulative
therapeutic
effects.
Functionalized
polydopamine
(PDA)-coated
Bi
particles
having
a
core-shell
structure
may
such
infections.
We
fabricated
new
advanced
material
based
on
Tris-functionalized
PDA
using
facile
three-step
protocol
for
healing
drug-resistant
The
fabrication
of
particles,
coating
their
Tris
functionalization
were
confirmed
by
X-ray
diffraction,
spectroscopic
thermogravimetric
analyses.
PDA-coated
abbreviated
as
Bi/PDA-Tris,
exhibited
higher
average
diameter,
improved
hydrophilicity,
aqueous
dispersity,
colloidal
stability.
Bi/PDA-Tris
showed
delicate
surface
morphology,
narrow
size
distribution,
spherical
shape,
structure.
In
vitro
bovine
serum
albumin
hemolysis
assays
minimal
protein
adsorption
desirable
hemocompatibility
Bi/PDA-Tris.
Antibacterial
gentamicin
(GM)-immobilized
pH-mediated
sustained
drug
release
kinetics
under
acidic
conditions.
in
study
GM-loaded
significant
growth
inhibition
bactericidal
activity.
effectively
antibacterial
shell
conditions
target
heal
This
approach
has
introduced
economic,
nontoxic,
easy-to-use,
relatively
more
biocompatible
substituent
precise
metals
like
Pt,
Au,
Ag
development
composite
materials.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Март 10, 2025
Cancer
remains
a
significant
global
health
challenge,
driving
the
search
for
innovative
treatments.
Photothermal
therapy
(PTT)
has
emerged
as
promising
approach,
using
photothermal
agents
to
convert
near-infrared
(NIR)
light
into
heat
tumor
ablation.
Among
these
agents,
nano-molybdenum
oxide,
particularly
non-stoichiometric
MoO3-x
(0
<
x
1),
stands
out
due
its
unique
defect
structure,
strong
NIR
absorption,
high
conversion
efficiency
(PCE),
and
pH-responsive
degradation.
This
review
summarized
recent
advancements
in
oxide
PTT,
covering
classification,
synthesis,
surface
modification,
tumor-targeting
mechanisms.
Subsequently,
we
explored
applications
PTT
combination
therapies,
evaluated
biocompatibility
toxicity,
discussed
current
achievements,
challenges,
future
perspectives
cancer
treatment.
