Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Язык: Английский

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The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles

Vaccines, Год журнала: 2025, Номер 13(4), С. 337 - 337

Опубликована: Март 21, 2025

Dendritic cells (DCs) act as a bridge between innate and adaptive immunity by presenting antigens to effector immune have shown broad application potential in tumor immunotherapy. However, the clinical translation of DC vaccines encounters significant challenges, such immunosuppressive microenvironment (TME) sub-optimal function vaccine efficacy vivo. In this review, our investigation has uncovered latest developments their cancer immunotherapy, with special emphasis on integration nanotechnology. Several types nanomaterials, including protein cage nanoparticles (NPs), biomimetic NPs, targeted multifunctional been developed enhance antigen presentation ability DCs stimulatory effects T cells. addition, we also summarized synergistic anti-cancer checkpoint inhibitors, chemotherapy, radiotherapy. recent advances nanotechnology made it possible develop novel biomarkers that can capacity stimulate These not only improve accuracy precision design but provide new insights into understanding mechanisms DC-mediated response. Despite challenges pertaining technical complexities individual adaptation production vaccines, personalized immunotherapy based is expected become an important part treatment rapid biotechnology immunology. This review provides perspectives solutions for optimal therapy.

Язык: Английский

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Remodeling tumor microenvironment by versatile nanoplatform orchestrated mechanotherapy with chemoimmunotherapy to synergistically enhance anticancer efficiency

Biomaterials, Год журнала: 2025, Номер 317, С. 123104 - 123104

Опубликована: Янв. 10, 2025

Язык: Английский

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Double‐Layer Microneedle Patch Loaded with HA‐PBA‐QCT for Management of Paclitaxel‐Induced Peripheral Neuropathic Pain

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Chemotherapy-induced neuropathic pain (CINP) is a common adverse effect of antineoplastic drugs, often leading to dose reduction, treatment delays, or cessation chemotherapy. Chemotherapy agents, like paclitaxel (PTX), damage the somatosensory nervous system by inducing neuroinflammation and oxidative stress, resulting in sensitization sensory neurons. Quercetin (QCT), known for its anti-inflammatory, antioxidant, neuroprotective properties, investigated various neurological disorders. This work creates phenylboronic acid-modified hyaluronic acid (HA-PBA) gels with incorporated QCT fabricates double-layer microneedle (MN) patch using an HA-PBA-QCT complex needles HA/polyvinyl alcohol (PVA) as substrate. The crosslinking between PVA enables controlled, sustained release upon application. applies these QCT-loaded (QMN) patches instep skin PTX-treated mice, which exhibits mechanical allodynia cold hyperalgesia. Biweekly applications QMN significantly reduce responses. analgesic associated modulation satellite glial cell activity, decreased macrophage infiltration, reduced TNF-α IL-6 levels dorsal root ganglia (DRGs). Additionally, improves cellular antioxidant capacity, indicated upregulated Nrf2 catalase DRGs. Overall, findings suggest that offer long-term anti-inflammatory benefits, potentially alleviating CINP patients.

Язык: Английский

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Rapid and portable detection of hepatocellular carcinoma marker alpha-fetoprotein using a droplet evaporation-based biosensor

Talanta, Год журнала: 2025, Номер 294, С. 128189 - 128189

Опубликована: Апрель 18, 2025

Язык: Английский

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