Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100040 - 100040
Опубликована: Июнь 27, 2024
Currently,
cancer
is
the
leading
cause
of
death
globally.
In
absence
specific
treatment
and
early
diagnosis,
procedures
like
surgery,
chemotherapy,
radiation
therapy
are
often
used
to
manage
disease.
However,
these
approaches
fail
control
due
inefficacy,
nonspecific
distribution,
side
effects
drugs.
Anticancer
drugs
essential
in
reducing
cell
growth
helping
damage
those
cells.
severe
have
limited
bioavailability
their
distribution
throughout
body.
Therefore,
development
intelligent
drug
release
systems
essential.
Nanoparticle
delivery
promising
strategies
improve
therapeutic
efficacy
safety,
overcoming
challenges.
Among
systems,
a
natural
polysaccharide
called
chitosan,
derivative
chitin,
has
gained
considerable
attention
as
biocompatible,
biodegradable,
mucoadhesive
material
for
creating
nanoparticles.
Chitosan
nanoparticles
provide
several
advantages,
including
improved
stability,
cellular
uptake,
solubility
anticancer
drugs,
modulation
kinetics,
biodistribution.
Additionally,
chitosan
can
be
modified
on
surface
with
ligands
or
stimuli-responsive
moieties
achieve
targeted
cells
tissues.
This
review
explores
recent
advances
chitosan-based
nanoparticle
delivery,
efficacy,
applications
therapy.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Gels,
Год журнала:
2024,
Номер
10(3), С. 175 - 175
Опубликована: Фев. 29, 2024
The
management
of
wound
healing
represents
a
significant
clinical
challenge
due
to
the
complicated
processes
involved.
Chitosan
has
remarkable
properties
that
effectively
prevent
certain
microorganisms
from
entering
body
and
positively
influence
both
red
blood
cell
aggregation
platelet
adhesion
in
bloodstream,
resulting
favorable
hemostatic
outcome.
In
recent
years,
chitosan-based
hydrogels
have
been
widely
used
as
dressings
their
biodegradability,
biocompatibility,
safety,
non-toxicity,
bioadhesiveness,
soft
texture
resembling
extracellular
matrix.
This
article
first
summarizes
an
overview
main
chemical
modifications
chitosan
for
then
reviews
desired
hydrogel
dressings.
applications
healing,
including
burn
wounds,
surgical
infected
diabetic
wounds
are
discussed.
Finally,
future
prospects
It
is
anticipated
this
review
will
form
basis
development
range
treatment.
Nano TransMed,
Год журнала:
2024,
Номер
3, С. 100040 - 100040
Опубликована: Июнь 27, 2024
Currently,
cancer
is
the
leading
cause
of
death
globally.
In
absence
specific
treatment
and
early
diagnosis,
procedures
like
surgery,
chemotherapy,
radiation
therapy
are
often
used
to
manage
disease.
However,
these
approaches
fail
control
due
inefficacy,
nonspecific
distribution,
side
effects
drugs.
Anticancer
drugs
essential
in
reducing
cell
growth
helping
damage
those
cells.
severe
have
limited
bioavailability
their
distribution
throughout
body.
Therefore,
development
intelligent
drug
release
systems
essential.
Nanoparticle
delivery
promising
strategies
improve
therapeutic
efficacy
safety,
overcoming
challenges.
Among
systems,
a
natural
polysaccharide
called
chitosan,
derivative
chitin,
has
gained
considerable
attention
as
biocompatible,
biodegradable,
mucoadhesive
material
for
creating
nanoparticles.
Chitosan
nanoparticles
provide
several
advantages,
including
improved
stability,
cellular
uptake,
solubility
anticancer
drugs,
modulation
kinetics,
biodistribution.
Additionally,
chitosan
can
be
modified
on
surface
with
ligands
or
stimuli-responsive
moieties
achieve
targeted
cells
tissues.
This
review
explores
recent
advances
chitosan-based
nanoparticle
delivery,
efficacy,
applications
therapy.
