Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs DOI Creative Commons

Anil Kumar Grewal,

Raj Kumar Salar

Nano TransMed, Год журнала: 2024, Номер 3, С. 100040 - 100040

Опубликована: Июнь 27, 2024

Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.

Язык: Английский

Development of chitosan biopolymer by chemically modified orange peel for safranin O dye removal: A sustainable adsorbent and adsorption modeling using RSM-BBD DOI

Mohammad K.A. Khan,

Ahmed Saud Abdulhameed, Hassan Alshahrani

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129964 - 129964

Опубликована: Фев. 3, 2024

Язык: Английский

Процитировано

21

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy DOI Creative Commons

Ming‐Hui Fan,

Jin-Kui Pi,

Chen‐Yu Zou

и другие.

Bioactive Materials, Год журнала: 2024, Номер 38, С. 1 - 30

Опубликована: Апрель 23, 2024

Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.

Язык: Английский

Процитировано

21

A review of advancements in chitosan-essential oil composite films: Better and sustainable food preservation with biodegradable packaging DOI
Zhiqing Liu, Siting Wang, Hui Liang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 274, С. 133242 - 133242

Опубликована: Июнь 17, 2024

Язык: Английский

Процитировано

20

Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings DOI Creative Commons

Wei Guo,

Xiaoyue Ding,

Han Zhang

и другие.

Gels, Год журнала: 2024, Номер 10(3), С. 175 - 175

Опубликована: Фев. 29, 2024

The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering body and positively influence both red blood cell aggregation platelet adhesion in bloodstream, resulting favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as dressings their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, soft texture resembling extracellular matrix. This article first summarizes an overview main chemical modifications chitosan for then reviews desired hydrogel dressings. applications healing, including burn wounds, surgical infected diabetic wounds are discussed. Finally, future prospects It is anticipated this review will form basis development range treatment.

Язык: Английский

Процитировано

18

Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs DOI Creative Commons

Anil Kumar Grewal,

Raj Kumar Salar

Nano TransMed, Год журнала: 2024, Номер 3, С. 100040 - 100040

Опубликована: Июнь 27, 2024

Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.

Язык: Английский

Процитировано

18