Environmental Health and Preventive Medicine,
Год журнала:
2023,
Номер
28(0), С. 29 - 29
Опубликована: Янв. 1, 2023
According
to
recent
reports,
individuals
with
reduced
aldehyde
dehydrogenase
activity
may
require
more
energy
for
the
detoxification
of
aldehydes.
Aldehyde
2
(ALDH2),
an
ALDH
isozyme,
is
responsible
detoxifying
acetaldehyde,
intermediate
metabolite
ethanol.
Because
variant
allele
rs671
polymorphism
ALDH2
results
in
a
substantial
reduction
enzymatic
activity,
carriers
this
have
higher
demand
when
consuming
alcohol
than
non-carriers.
However,
no
studies
evaluated
phenomenon
date.To
test
hypothesis,
we
statistically
examined
interactive
effects
between
and
ethanol
consumption
on
intake
using
cross-sectional
data
from
population-based
cohort
study,
Japan
Multi-Institutional
Collaborative
Cohort
Study,
which
was
conducted
Saga
city
2005-2007
(N
=
12,068).General
linear
regression
models
adjusted
age,
sex,
consumption,
current
smoking
status,
years
education,
dietary
restriction,
medical
history,
physical
level
revealed
that
non-carriers
among
drinking
habits,
whereas
such
correlation
observed
those
without
habits
(≤2
g
ethanol/day)
(p
0.03
interaction
consumption).
Energy
excluding
alcoholic
beverages,
carbohydrate
intake,
protein
fat
showed
similar
tendencies
0.01,
0.04,
0.07,
respectively).These
findings
support
hypothesis
increased
required
aldehydes
low
activity.
This
epidemiological
evidence
provides
possible
scientific
basis
understanding
mechanisms
suggests
novel
phenotype
polymorphism.
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Март 7, 2025
Andrographolide
(AP)
has
been
shown
to
possess
anti-inflammatory
activities.
In
this
study,
the
impact
of
AP
in
sepsis-induced
acute
liver
injury
(ALI)
and
molecules
involved
were
dissected.
FKBP1A
was
predicted
be
sole
target
protein
that
also
differentially
expressed
GSE166868
dataset.
induced
expression
suppressed
NOTCH1
a
dose-dependent
manner.
ameliorated
ALI
mice
by
D-galactosamine
LPS
inhibited
LPS-induced
parenchymal
cell
vitro.
By
contrast,
protective
effect
significantly
lost
after
knockdown
FKBP1A.
As
positive
control,
therapeutic
dexamethasone
on
may
related
NOTCH1,
which
not
promoted
AK2
transcription
cells,
endoplasmic
reticulum
(ER)
stress
impairing
NOTCH1/AK2
signaling.
Restoration
reversed
hepatoprotective
activating
ER
pathway.
Therefore,
AP-promoted
inhibits
progression
blocking
NOTCH1/AK2-mediated
Seminars in Liver Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 29, 2025
Alcohol
is
generally
believed
to
be
metabolized
in
the
liver
by
alcohol
dehydrogenase
(ADH),
aldehyde
(ALDH),
and
a
much
lesser
extent
cytochrome
P450
2E1
(CYP2E1)
other
enzymes.
Recent
studies
suggest
that
gut
also
play
important
roles
promotion
of
metabolism.
ADH,
ALDH,
CYP2E1
have
several
polymorphisms
markedly
impact
These
alcohol-metabolizing
enzymes
not
only
affect
alcohol-associated
disease
(ALD),
but
may
modulate
pathogenesis
diseases
cancer
absence
consumption.
In
this
review,
we
discuss
metabolism
ALD,
metabolic
dysfunction–associated
steatotic
disease,
dysfunction
alcohol–associated
viral
hepatitis,
cancer.
We
how
endogenous
ethanol
production,
affects
Directions
for
future
research
on
are
elaborated.
The American Journal of Chinese Medicine,
Год журнала:
2025,
Номер
53(03), С. 863 - 888
Опубликована: Янв. 1, 2025
The
aim
of
this
study
was
to
evaluate
the
therapeutic
effect
puerarin
(PUE)
on
alcoholic
liver
disease
(ALD)
and
elucidate
potential
mechanism
from
perspective
lipolysis
hepatic
steatosis.
Assessment
PUE
efficacy
against
ALD
performed
using
serum
biochemical
parameters
histological
examination
adipose
tissue
via
Hematoxylin
eosin
(H&E)
staining.
mechanisms
underlying
amelioration
by
were
investigated
Western
blotting
(WB)
analysis
immunofluorescence
(IHC)
We
demonstrated
that
attenuated
steatosis
in
alleviating
ethanol-induced
damage
lipid
accumulation,
suppressing
expression
synthesis
genes,
upregulating
metabolism
reducing
inhibiting
triglyceride
lipase
(ATGL)
activation
phosphorylation
hormone-sensitive
(HSL).
In
conclusion,
ameliorates
sympathetic
outflow-mediated
key
enzymes
ATGL
HSL.
These
findings
provide
a
solid
theoretical
foundation
for
application
clinical
treatment
ALD.
Environmental Health and Preventive Medicine,
Год журнала:
2023,
Номер
28(0), С. 29 - 29
Опубликована: Янв. 1, 2023
According
to
recent
reports,
individuals
with
reduced
aldehyde
dehydrogenase
activity
may
require
more
energy
for
the
detoxification
of
aldehydes.
Aldehyde
2
(ALDH2),
an
ALDH
isozyme,
is
responsible
detoxifying
acetaldehyde,
intermediate
metabolite
ethanol.
Because
variant
allele
rs671
polymorphism
ALDH2
results
in
a
substantial
reduction
enzymatic
activity,
carriers
this
have
higher
demand
when
consuming
alcohol
than
non-carriers.
However,
no
studies
evaluated
phenomenon
date.To
test
hypothesis,
we
statistically
examined
interactive
effects
between
and
ethanol
consumption
on
intake
using
cross-sectional
data
from
population-based
cohort
study,
Japan
Multi-Institutional
Collaborative
Cohort
Study,
which
was
conducted
Saga
city
2005-2007
(N
=
12,068).General
linear
regression
models
adjusted
age,
sex,
consumption,
current
smoking
status,
years
education,
dietary
restriction,
medical
history,
physical
level
revealed
that
non-carriers
among
drinking
habits,
whereas
such
correlation
observed
those
without
habits
(≤2
g
ethanol/day)
(p
0.03
interaction
consumption).
Energy
excluding
alcoholic
beverages,
carbohydrate
intake,
protein
fat
showed
similar
tendencies
0.01,
0.04,
0.07,
respectively).These
findings
support
hypothesis
increased
required
aldehydes
low
activity.
This
epidemiological
evidence
provides
possible
scientific
basis
understanding
mechanisms
suggests
novel
phenotype
polymorphism.
