Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(5)
Опубликована: Сен. 1, 2024
In
recent
years,
the
application
of
radionuclides-containing
nanomaterials
in
cancer
treatment
has
garnered
widespread
attention.
The
diversity
allows
researchers
to
selectively
combine
them
with
appropriate
radionuclides
for
biomedical
purposes,
addressing
challenges
faced
by
peptides,
small
molecules,
or
antibodies
used
radionuclide
labeling.
However,
advantages
come
challenges,
and
nanoradionuclides
still
encounter
significant
issues
during
clinical
translation.
This
review
summarized
progress
nanosized
diagnosis.
discussion
began
representative
methods
incorporating
into
nanomaterial
structures.
Subsequently,
new
combinations
radionuclides,
along
their
applications,
were
introduced
demonstrate
future
trends.
benefits
included
optimized
pharmacokinetic
properties,
enhanced
disease-targeting
efficacy,
synergistic
other
techniques.
Besides,
basic
rule
this
section
was
summarize
how
these
can
truly
impact
diagnosis
therapy
various
types.
last
part,
focus
devoted
currently
applicable
clinics
address
existing
problems
based
on
our
knowledge.
Pharmaceutics,
Год журнала:
2021,
Номер
13(5), С. 634 - 634
Опубликована: Апрель 29, 2021
Radium-224-labeled
CaCO3
microparticles
have
been
developed
to
treat
peritoneal
carcinomatosis.
The
function
as
carriers
of
224Ra,
facilitating
intraperitoneal
retention
the
alpha-emitting
radionuclide.
It
was
necessary
control
size
in
suspension
over
time
and
introduce
a
sterilization
process
for
clinical
use
radiopharmaceutical.
Ethylenediamine
tetra(methylene
phosphonic
acid)
(EDTMP)
investigated
stabilizing
additive.
possibility
encapsulating
radiolabeled
with
an
outer
surface
layer
improved
radioactivity
by
carrier
studied.
This
work
evaluated
these
steps
optimization
their
effect
on
radiochemical
purity,
biodistribution
radionuclides,
therapeutic
efficacy.
An
EDTMP
concentration
>1%
(w/w)
relative
stabilized
particle
at
least
one
week.
Without
EDTMP,
median
increased
from
~5
µm
~25
immediately
after
autoclaving,
larger
sedimented
rapidly
suspension.
percentage
adsorbed
224Ra
progeny
212Pb
56%
94%
2.4–2.5%
when
224Ra-labeled
were
layer-encapsulated.
formulation
also
resulted
suitable
radionuclides
mice,
well
survival
benefit
mice
ovarian
or
colorectal
tumors.
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1719 - 1719
Опубликована: Июнь 13, 2023
The
actinium-225
(225Ac)
radioisotope
exhibits
highly
attractive
nuclear
properties
for
application
in
radionuclide
therapy.
However,
the
225Ac
presents
multiple
daughter
nuclides
its
decay
chain,
which
can
escape
targeted
site,
circulate
plasma,
and
cause
toxicity
areas
such
as
kidneys
renal
tissues.
Several
ameliorative
strategies
have
been
devised
to
circumvent
this
issue,
including
nano-delivery.
Alpha-emitting
radionuclides
nanotechnology
applications
medicine
culminated
major
advancements
that
offer
promising
therapeutic
possibilities
treating
several
cancers.
Accordingly,
importance
of
nanomaterials
retaining
daughters
from
recoiling
into
unintended
organs
has
established.
This
review
expounds
on
therapy
(TRT)
an
alternative
anticancer
treatment.
It
discusses
recent
developments
preclinical
clinical
investigations
a
prospective
agent.
Moreover,
rationale
using
improving
efficacy
α-particles
alpha
(TAT)
with
emphasis
is
discussed.
Quality
control
measures
preparation
225Ac-conjugates
are
also
highlighted.
Nano-
and
microparticles
are
increasingly
widely
used
in
biomedical
research
applications,
particularly
as
specific
labels
targeted
delivery
vehicles.
Silica
has
long
been
considered
the
best
material
for
such
vehicles,
but
it
some
disadvantages
limiting
its
potential,
proneness
of
silica-based
carriers
to
spontaneous
drug
release.
Calcium
carbonate
(CaCO3)
is
an
emerging
alternative,
being
easily
available,
cost-effective,
biocompatible
with
high
porosity
surface
reactivity,
which
makes
attractive
choice
delivery.
CaCO3
particles
this
field
form
either
bare
microbeads
or
core/shell
representing
polymer-coated
cores.
In
addition,
they
serve
removable
templates
obtaining
hollow
polymer
microcapsules.
Each
these
types
advantages
terms
applications.
primarily
due
their
capacity
carrying
pharmaceutics,
whereas
systems
ensure
better
protection
drug-loaded
core
from
environment.
Hollow
capsules
because
can
encapsulate
large
amounts
pharmaceutical
agents
be
so
designed
release
contents
target
site
response
stimuli.
This
review
focuses
first
on
chemistry
cores,
microbeads,
Then,
using
structures
therapeutic
agents,
including
drugs,
proteins,
DNA,
outlined.
The
results
systematic
analysis
available
data
presented.
They
show
that
encapsulation
various
CaCO3-based
microcapsules
a
promising
technique
delivery,
especially
cancer
therapy,
enhancing
bioavailability
targeting
cells
while
reducing
side
effects.
To
date,
assembled
mainly
dealt
properties
vitro,
vivo
behavior
still
remains
poorly
studied.
However,
enormous
potential
highly
applications
undoubted.
last
issue
addressed
depth
Conclusion
Outlook
sections
review.
Inorganic Chemistry,
Год журнала:
2022,
Номер
61(19), С. 7217 - 7221
Опубликована: Май 5, 2022
Here
we
show
that
the
praseodymium
N,N-dimethylaminodiboranate
complex
Pr(H3BNMe2BH3)3
and
2,2,6,6-tetramethylheptane-3,5-dionate
Pr(thd)3
can
serve
as
volatile
carriers
for
225Ac.
The
actinium
coordination
complexes
Ac(H3BNMe2BH3)3
Ac(thd)3
are
likely
species
subliming
with
carrier
material.
A
sample
of
225Ac-doped
was
used
to
deposit
amorphous
boride
films
on
glass
Si(100)
at
300
°C.
α
emission
spectra
refractory
well-resolved,
suggesting
they
could
be
radioactive
implants
brachytherapy
related
treatments.
Materials,
Год журнала:
2021,
Номер
14(23), С. 7130 - 7130
Опубликована: Ноя. 23, 2021
Lead-212
is
recognized
as
a
promising
radionuclide
for
targeted
alpha
therapy
tumors.
Many
studies
of
212Pb-labeling
various
biomolecules
through
bifunctional
chelators
have
been
conducted.
Another
approach
to
exploiting
the
cytotoxic
effect
coupling
microparticle
acting
carrier
vehicle,
which
could
be
used
treating
disseminated
cancers
in
body
cavities.
Calcium
carbonate
may
represent
suitable
material,
it
biocompatible,
biodegradable,
and
easy
synthesize.
In
this
work,
we
explored
CaCO3
microparticles
developed
protocol
that
can
straightforwardly
implemented
by
clinicians.
Vaterite
stabilized
pamidronate
were
effective
212Pb
carriers;
labeling
yields
≥98%
achieved,
was
strongly
retained
particles
an
vitro
stability
assessment.
Moreover,
amounts
reaching
kidneys,
liver,
spleen,
skeleton
mice
following
intraperitoneal
(i.p.)
administration
very
low
compared
i.p.
injection
unbound
212Pb2+,
indicating
CaCO3-bound
exhibited
when
administered
intraperitoneally.
Therapeutic
efficacy
observed
model
ovarian
cancer
all
tested
doses,
ranging
from
63
430
kBq
per
mouse.
Lead-212-labeled
candidate
intracavitary
cancers.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(29), С. 32788 - 32798
Опубликована: Июль 13, 2022
Porous
materials,
such
as
zeolites,
have
great
potential
for
biomedical
applications,
thanks
to
their
ability
accommodate
positively
charged
metal-ions
and
facile
surface
functionalization.
Although
the
latter
aspect
is
important
endow
nanoparticles
with
chemical/colloidal
stability
desired
biological
properties,
possibility
simple
ion-exchange
enables
easy
switching
between
imaging
modalities
and/or
combination
therapy,
depending
on
envisioned
application.
In
this
study,
nanozeolite
Linde
type
L
(LTL)
already
confirmed
magnetic
resonance
generated
by
paramagnetic
gadolinium
(GdIII)
in
inner
cavities,
was
successfully
radiolabeled
a
positron
emission
tomography
(PET)-tracer
zirconium-89
(89Zr).
Thereby,
exploiting
89Zr-chloride
resulted
slightly
higher
radiolabeling
cavities
compared
commonly
used
89Zr-oxalate,
which
apparently
remained
of
LTL.
Intravenous
injection
PEGylated
89Zr/GdIII-LTL
healthy
mice
allowed
PET-computed
evaluation,
revealing
initial
lung
uptake
followed
gradual
migration
LTL
liver
spleen.
Ex
vivo
biodistribution
integrity
proposed
multimodal
probe
demonstrating
original
metal/Si
ratio
being
preserved
organs.
These
findings
reveal
beneficial
behavior
hence
open
door
follow-up
theranostic
studies
immense
variety
metal-based
radioisotopes.
Interdisciplinary cancer research,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Targeted
alpha
therapy
(TAT)
has
emerged
as
a
viable
therapeutic
option
for
cancer
management,
due
to
its
high
target
specificity
and
superlative
ability
effectively
disrupt
the
genetic
make-up
of
cancerous
cells,
thereby
impeding
their
aggressive
growth.
TAT
belongs
category
radioligand
therapies
in
oncology
wherein
alpha-emitting
radionuclides
are
delivered
directly
tumours
tumour
microenvironment
with
little
impact
on
surrounding
healthy
cells.
This
approach
is
facilitated
by
chelating
ligands
or
conjugating
them
targeting
vehicles
which
facilitate
biodistribution,
localization,
accumulation
sites.
Currently,
continues
exhibit
promising
outcomes
both
preclinical
clinical
evaluations,
more
exciting
prospects
future.
Accordingly,
this
timely
review
focuses
pertinent,
appealing
merits
TAT,
elaborating
favourable
chemical
properties
potent
enhancement.
The
current
also
delves
into
radiobiology
dosimetry
alpha-particles,
application
TAT.
Recent
reports
have
further
supported
viability
intervention.
More
so,
sheds
light
possibilities
that
nuclear
medicine,
particularly
can
offer
oncology.