Impact of metallic coating on the retention of 225Ac and its daugthers within core–shell nanocarriers

Journal of Colloid and Interface Science, Год журнала: 2021, Номер 608, С. 2571 - 2583

Опубликована: Ноя. 2, 2021

Язык: Английский

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Improved Formulation of 224Ra-Labeled Calcium Carbonate Microparticles by Surface Layer Encapsulation and Addition of EDTMP

Pharmaceutics, Год журнала: 2021, Номер 13(5), С. 634 - 634

Опубликована: Апрель 29, 2021

Radium-224-labeled CaCO3 microparticles have been developed to treat peritoneal carcinomatosis. The function as carriers of 224Ra, facilitating intraperitoneal retention the alpha-emitting radionuclide. It was necessary control size in suspension over time and introduce a sterilization process for clinical use radiopharmaceutical. Ethylenediamine tetra(methylene phosphonic acid) (EDTMP) investigated stabilizing additive. possibility encapsulating radiolabeled with an outer surface layer improved radioactivity by carrier studied. This work evaluated these steps optimization their effect on radiochemical purity, biodistribution radionuclides, therapeutic efficacy. An EDTMP concentration >1% (w/w) relative stabilized particle at least one week. Without EDTMP, median increased from ~5 µm ~25 immediately after autoclaving, larger sedimented rapidly suspension. percentage adsorbed 224Ra progeny 212Pb 56% 94% 2.4–2.5% when 224Ra-labeled were layer-encapsulated. formulation also resulted suitable radionuclides mice, well survival benefit mice ovarian or colorectal tumors.

Язык: Английский

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RETRACTED: Theoretical simulation and experimental design of selenium and gold incorporated polymer-based microcarriers for ROS-mediated combined photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 643, С. 232 - 246

Опубликована: Апрель 10, 2023

Язык: Английский

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Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review

Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1719 - 1719

Опубликована: Июнь 13, 2023

The actinium-225 (225Ac) radioisotope exhibits highly attractive nuclear properties for application in radionuclide therapy. However, the 225Ac presents multiple daughter nuclides its decay chain, which can escape targeted site, circulate plasma, and cause toxicity areas such as kidneys renal tissues. Several ameliorative strategies have been devised to circumvent this issue, including nano-delivery. Alpha-emitting radionuclides nanotechnology applications medicine culminated major advancements that offer promising therapeutic possibilities treating several cancers. Accordingly, importance of nanomaterials retaining daughters from recoiling into unintended organs has established. This review expounds on therapy (TRT) an alternative anticancer treatment. It discusses recent developments preclinical clinical investigations a prospective agent. Moreover, rationale using improving efficacy α-particles alpha (TAT) with emphasis is discussed. Quality control measures preparation 225Ac-conjugates are also highlighted.

Язык: Английский

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Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment

Опубликована: Апрель 3, 2024

Nano- and microparticles are increasingly widely used in biomedical research applications, particularly as specific labels targeted delivery vehicles. Silica has long been considered the best material for such vehicles, but it some disadvantages limiting its potential, proneness of silica-based carriers to spontaneous drug release. Calcium carbonate (CaCO3) is an emerging alternative, being easily available, cost-effective, biocompatible with high porosity surface reactivity, which makes attractive choice delivery. CaCO3 particles this field form either bare microbeads or core/shell representing polymer-coated cores. In addition, they serve removable templates obtaining hollow polymer microcapsules. Each these types advantages terms applications. primarily due their capacity carrying pharmaceutics, whereas systems ensure better protection drug-loaded core from environment. Hollow capsules because can encapsulate large amounts pharmaceutical agents be so designed release contents target site response stimuli. This review focuses first on chemistry cores, microbeads, Then, using structures therapeutic agents, including drugs, proteins, DNA, outlined. The results systematic analysis available data presented. They show that encapsulation various CaCO3-based microcapsules a promising technique delivery, especially cancer therapy, enhancing bioavailability targeting cells while reducing side effects. To date, assembled mainly dealt properties vitro, vivo behavior still remains poorly studied. However, enormous potential highly applications undoubted. last issue addressed depth Conclusion Outlook sections review.

Язык: Английский

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Pr(H₃BNMe₂BH₃)₃ and Pr(thd)₃ as Volatile Carriers for Actinium-225. Deposition of Actinium-Doped Praseodymium Boride Thin Films for Potential Use in Brachytherapy

Inorganic Chemistry, Год журнала: 2022, Номер 61(19), С. 7217 - 7221

Опубликована: Май 5, 2022

Here we show that the praseodymium N,N-dimethylaminodiboranate complex Pr(H3BNMe2BH3)3 and 2,2,6,6-tetramethylheptane-3,5-dionate Pr(thd)3 can serve as volatile carriers for 225Ac. The actinium coordination complexes Ac(H3BNMe2BH3)3 Ac(thd)3 are likely species subliming with carrier material. A sample of 225Ac-doped was used to deposit amorphous boride films on glass Si(100) at 300 °C. α emission spectra refractory well-resolved, suggesting they could be radioactive implants brachytherapy related treatments.

Язык: Английский

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Preclinical studies of automated radiolabeled microcarriers for radiosynovectomy of inflammatory joint disease

Applied Materials Today, Год журнала: 2022, Номер 29, С. 101571 - 101571

Опубликована: Июнь 25, 2022

Язык: Английский

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A Novel Single-Step-Labeled 212Pb-CaCO3 Microparticle for Internal Alpha Therapy: Preparation, Stability, and Preclinical Data from Mice

Materials, Год журнала: 2021, Номер 14(23), С. 7130 - 7130

Опубликована: Ноя. 23, 2021

Lead-212 is recognized as a promising radionuclide for targeted alpha therapy tumors. Many studies of 212Pb-labeling various biomolecules through bifunctional chelators have been conducted. Another approach to exploiting the cytotoxic effect coupling microparticle acting carrier vehicle, which could be used treating disseminated cancers in body cavities. Calcium carbonate may represent suitable material, it biocompatible, biodegradable, and easy synthesize. In this work, we explored CaCO3 microparticles developed protocol that can straightforwardly implemented by clinicians. Vaterite stabilized pamidronate were effective 212Pb carriers; labeling yields ≥98% achieved, was strongly retained particles an vitro stability assessment. Moreover, amounts reaching kidneys, liver, spleen, skeleton mice following intraperitoneal (i.p.) administration very low compared i.p. injection unbound 212Pb2+, indicating CaCO3-bound exhibited when administered intraperitoneally. Therapeutic efficacy observed model ovarian cancer all tested doses, ranging from 63 430 kBq per mouse. Lead-212-labeled candidate intracavitary cancers.

Язык: Английский

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On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(29), С. 32788 - 32798

Опубликована: Июль 13, 2022

Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability accommodate positively charged metal-ions and facile surface functionalization. Although the latter aspect is important endow nanoparticles with chemical/colloidal stability desired biological properties, possibility simple ion-exchange enables easy switching between imaging modalities and/or combination therapy, depending on envisioned application. In this study, nanozeolite Linde type L (LTL) already confirmed magnetic resonance generated by paramagnetic gadolinium (GdIII) in inner cavities, was successfully radiolabeled a positron emission tomography (PET)-tracer zirconium-89 (89Zr). Thereby, exploiting 89Zr-chloride resulted slightly higher radiolabeling cavities compared commonly used 89Zr-oxalate, which apparently remained of LTL. Intravenous injection PEGylated 89Zr/GdIII-LTL healthy mice allowed PET-computed evaluation, revealing initial lung uptake followed gradual migration LTL liver spleen. Ex vivo biodistribution integrity proposed multimodal probe demonstrating original metal/Si ratio being preserved organs. These findings reveal beneficial behavior hence open door follow-up theranostic studies immense variety metal-based radioisotopes.

Язык: Английский

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Targeted Alpha Therapy in Cancer Management: Therapeutic Prospects of Nuclear Medicine in Oncology

Interdisciplinary cancer research, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Targeted alpha therapy (TAT) has emerged as a viable therapeutic option for cancer management, due to its high target specificity and superlative ability effectively disrupt the genetic make-up of cancerous cells, thereby impeding their aggressive growth. TAT belongs category radioligand therapies in oncology wherein alpha-emitting radionuclides are delivered directly tumours tumour microenvironment with little impact on surrounding healthy cells. This approach is facilitated by chelating ligands or conjugating them targeting vehicles which facilitate biodistribution, localization, accumulation sites. Currently, continues exhibit promising outcomes both preclinical clinical evaluations, more exciting prospects future. Accordingly, this timely review focuses pertinent, appealing merits TAT, elaborating favourable chemical properties potent enhancement. The current also delves into radiobiology dosimetry alpha-particles, application TAT. Recent reports have further supported viability intervention. More so, sheds light possibilities that nuclear medicine, particularly can offer oncology.

Язык: Английский

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