Biomaterials Advances, Год журнала: 2022, Номер 136, С. 212799 - 212799
Опубликована: Апрель 11, 2022
Язык: Английский
Pharmaceuticals, Год журнала: 2022, Номер 15(10), С. 1282 - 1282
Опубликована: Окт. 19, 2022
Advancements in the material design of smart hydrogels have transformed way therapeutic agents are encapsulated and released biological environments. On other hand, expeditious development 3D printing technologies has revolutionized fabrication hydrogel systems for biomedical applications. By combining these two aspects, 4D (i.e., hydrogels) emerged as a new promising platform novel controlled drug delivery that can adapt mimic natural physio-mechanical changes over time. This allows printed objects to transform from static dynamic response various physiological chemical interactions, meeting needs healthcare industry. In this review, we provide an overview innovation systems, current technical approaches toward printing, emerging structures Finally, discuss existing challenges their prospects.
Язык: Английский
Процитировано
43
Chemical Society Reviews, Год журнала: 2023, Номер 52(10), С. 3470 - 3542
Опубликована: Янв. 1, 2023
CO 2 -responsive gels respond to exposure by either changing their properties or switching between gel and non-gel states.
Язык: Английский
Процитировано
39
Deleted Journal, Год журнала: 2023, Номер 1(4)
Опубликована: Авг. 18, 2023
Abstract Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged an efficient bioactive multifunctional alternative. Hydrogels are three‐dimensional, water‐swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties hydrogels can be modified easily, allowing them to suitable various biomedical applications. Moreover, imparted through manipulations, making ideal candidates supplementing replacing traditional plaster. As result, sticky widely transdermal drug delivery even found commercial purposes. Beyond delivery, also applications in cardiac therapy, cancer research, biosensing, among other In mini‐review, we critically discuss challenges fabricating patches. Furthermore, introduce some chemical strategies involved with We review their emerging Finally, explore potential future flourishing field engineering delivery.
Язык: Английский
Процитировано
34
Chemical Engineering Journal, Год журнала: 2023, Номер 462, С. 142193 - 142193
Опубликована: Март 2, 2023
Язык: Английский
Процитировано
29
Theranostics, Год журнала: 2024, Номер 14(5), С. 1982 - 2035
Опубликована: Янв. 1, 2024
Many human tissues exhibit a highly oriented architecture that confers them with distinct mechanical properties, enabling adaptation to diverse and challenging environments. Hydrogels, their water-rich "soft wet" structure, have emerged as promising biomimetic materials in tissue engineering for repairing replacing damaged organs. Highly hydrogels can especially emulate the structural orientation found tissue, exhibiting unique physiological functions properties absent traditional homogeneous isotropic hydrogels. The design preparation of involve strategies like including nanofillers, polymer-chain networks, void channels, microfabricated structures. Understanding specific mechanism action how these affect cell behavior biological applications such cornea, skin, skeletal muscle, tendon, ligament, cartilage, bone, blood vessels, heart, etc., requires further exploration generalization. Therefore, this review aims fill gap by focusing on strategy application field engineering. Furthermore, we provide detailed discussion various organs mechanisms through which structures influence behavior.
Язык: Английский
Процитировано
16
Materials Today Advances, Год журнала: 2024, Номер 21, С. 100465 - 100465
Опубликована: Фев. 7, 2024
Hydrogels have emerged as promising biomaterials for nerve regeneration due to their adjustable properties, structural resemblance the extracellular matrix, and ability promote cell adhesion proliferation. This comprehensive review discusses advantages, challenges, future directions of various functional hydrogels. Advanced technologies fabricating Multistructured hydrogel, including injectable hydrogels, hydrogel microspheres, fibrous 3D printing nanogels, stem cell-loaded electrical ultrasound magnetic been developed studied regeneration. These demonstrate versatility hydrogels in neural tissue repair. However, challenges such biocompatibility, degradation rates, scaffold design need be addressed. Interdisciplinary research is necessary develop innovative systems that overcome these realize potential provides valuable insights into advanced highlights regenerative medicine, particularly Researchers can use this knowledge refine therapeutic approaches involving enhancing
Язык: Английский
Процитировано
14
Biomacromolecules, Год журнала: 2024, Номер 25(9), С. 5417 - 5436
Опубликована: Авг. 28, 2024
There has been growing interest in polymeric systems that break down or undergo property changes response to stimuli. Such polymers can play important roles biological systems, where they be used control the release of therapeutics, modulate imaging signals, actuate movement, direct growth cells. In this Perspective, after discussing most stimuli relevant applications, we will present a selection recent exciting developments. The importance stimuli-responsive polysaccharides discussed, followed by variety for delivery small molecule drugs and nucleic acids. Switchable emerging area therapeutic measurement theranostics described. Then, diverse functions achieved using hydrogels cross-linked covalently, as well various dynamic approaches presented. Finally, discuss some challenges future perspectives field.
Язык: Английский
Процитировано
13
Journal of Macromolecular Science Part A, Год журнала: 2024, Номер 61(5), С. 265 - 288
Опубликована: Март 19, 2024
Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.
Язык: Английский
Процитировано
12
Cell Reports Physical Science, Год журнала: 2024, Номер 5(3), С. 101819 - 101819
Опубликована: Фев. 6, 2024
External magnetic fields can regulate cellular responses when interacting with nanoparticles (MNPs). Here, we develop a 4D-bioprinted construct by incorporating anisotropic MNPs into silk fibroin-gelatin bioink human bone-marrow-derived mesenchymal stromal cells for cartilage regeneration. We measure the magnetic-field-induced temperature response of acellular construct, determine its mechanical (actuation), and compare it MNPs. Constructs are then magnetically actuated, their effects on chondrogenesis investigated. Actuation is induced cyclically every other day (5 min 30 min/day) 21 days. exhibits enhanced early (Sox-9 aggrecan) late (collagen-II) expression downregulation hypertrophic markers (collagen-X matrix metalloproteinase-13) deposition, total collagen, glycosaminoglycan compared to constructs actuated 5 min, kept static, or no Hence, field actuation could be significant strategy stimulate mechanically articular
Язык: Английский
Процитировано
11
Advanced Functional Materials, Год журнала: 2024, Номер 34(22)
Опубликована: Фев. 5, 2024
Abstract Although a widely used option in contemporary anticancer treatment, surgery still causes serious issues, including post‐operation recurrence and the development of metastases. Immunotherapy, often following surgical resection tumor, has demonstrated benefits improving therapeutical outcomes surgery. However, antigen generation presentation play an essential role reversing limited T‐cell responses or immunological resistance. Thus, gelatin‐tannic acid gel (GelTA) crosslinked bimetallic (Zn 0.35 Fe 0.65 ) magnetocaloric‐responsive hydrogels (GelTAMNPs) are developed to mediate pyroptosis‐relay‐immunotherapy for suppressing tumor metastasis. After GelTAMNPs generate hyperthermia inducible by alternating magnetic field release ions (Fe 3+ , 2+ Zn ), reinforcing pyroptosis. Subsequently, cell contents cytokines released due pyroptosis act as “relay baton” passed from lymph nodes, leading enhanced systemic immune response. Combined with PD‐1 checkpoint blockade, metastasis significantly suppressed. An vivo preclinical study on B16F10 tumor‐bearing mice demonstrates long‐lasting activation post‐surgical administration GelTAMNPs. Altogether, presented hydrogel exhibits potential high sensitive pyroptosis‐relay‐immunotherapeutic platform postoperative adjuvant treatment.
Язык: Английский
Процитировано
11