Chitosan nanoparticles as promising tool for berberine delivery: Formulation, characterization and in vivo evaluation

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 80, С. 104203 - 104203

Опубликована: Янв. 23, 2023

Язык: Английский

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Self-assembly and functional activity of amphiphilic conjugates of the diterpenoid isosteviol and triphenylphosphonium cation, with focusing on biotechnological potential

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 697, С. 134505 - 134505

Опубликована: Июнь 12, 2024

Язык: Английский

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Innovative lipid nanoparticles: A cutting-edge approach for potential renal cell carcinoma therapeutics

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117465 - 117465

Опубликована: Сен. 24, 2024

Язык: Английский

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Transport functions of intestinal lymphatic vessels

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Язык: Английский

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A Novel Approach for Bladder Cancer Treatment: Nanoparticles as a Drug Delivery System

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 13461 - 13483

Опубликована: Дек. 1, 2024

Bladder cancer represents one of the most prevalent malignant neoplasms urinary tract. In Asian context, it eighth common in males. 2022, there were approximately 613,791 individuals diagnosed with bladder worldwide. Despite availability efficacious treatments for two principal forms cancer, namely non-invasive and invasive high incidence recurrence following treatment suboptimal outcomes observed patients high-grade advanced disease represent significant concerns management at this juncture. Nanoparticles have gained attention their excellent properties, including stable physical a porous structure that can be loaded variety substances, so on. The in-depth research on nanoparticles has led to emergence as new class combination therapy, due advantageous properties. These include extension drug release window, enhancement bioavailability, improvement targeting ability, reduction local systemic toxicity, simultaneous delivery multiple drugs therapy. As result, become novel agent system. advent provided impetus development non-surgical chemotherapy, immunotherapy, gene therapy phototherapy. unique properties facilitated diverse therapeutic modalities, enhancing overall efficacy. This review examines recent advancements use treatments, encompassing aspects such delivery, efficacy, associated toxicity nanoparticles, well challenges encountered clinical applications.

Язык: Английский

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Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer

annals of urologic oncology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Bladder cancer is among most common malignancies worldwide, with significant morbidity and mortality. Conventional treatment strategies for bladder include transurethral resection, radical cystectomy chemotherapy. However, the complex immune landscape of involves innate adaptive components that either promote or suppress tumor progression. Upregulation checkpoint molecules like PD-L1 recruitment immunosuppressive cells, contribute to evasion resistance. Immune inhibitors such as nivolumab, pembrolizumab, avelumab, atezolizumab have shown promising results in clinical trials been approved metastatic high-risk cancer. Additionally, Bacillus Calmette-Guérin (BCG) immunotherapy has long use treatment. Furthermore, natural killer cell-based therapies novel targets TIGIT CD155 are under investigation enhance anti-tumor immunity. challenges toxic side-effects, variable response rates need predictive biomarkers persists. Nanotechnology offers solutions improve outcomes. Recent advances gold nanoparticles, TLR agonist-loaded exosome-based delivery systems boost responses. nanovaccine incorporating tumor-associated antigens adjuvants show potential personalized immunotherapy. Here, we discuss cancer, explore emerging immunotherapies being used treatment, advantages using nanoparticles carriers against By optimizing combination strategies, identifying immunotherapeutic targets, leveraging nanotechnology precision medicine, future holds great promise improving efficacy alleviating burden.

Язык: Английский

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Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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The role of nanotechnologies in diagnostics and treatment of female reproductive system cancer

Obstetrics Gynecology and Reproduction, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Introduction . By enhancing detection accuracy, therapeutic effectiveness and minimizing side effects, nanotechnology may contribute to improve diagnostics treatment of patients with female reproductive system cancer. Aim : summarize current literature data assess а role in cervical cancer (CC), ovarian (OC), endometrial (EC) reveal gaps requiring further research. Materials Methods The search was carried out the electronic databases PubMed/MEDLINE, Google Scholar eLibrary using following keywords: “gynecological cancer”, “targeted therapy”, “cervical “ovarian “endometrial “nanotechnology”, “nanoparticles”. All works were published between 2011 2024. Results Nanocarrier-based drug delivery systems represent a promising approach oncology, providing precise directly tumor cells. Such systems, including liposomes, nanoparticles, micelles, dendrimers, are characterized by advanced efficiency, reduced toxicity, as well opportunity for controlled release active components. Nanotechnologies increase vaccines prolonging their half-life, affect СС microenvironment potentiate antitumor immune response minimal toxicity. Nanovaccines capable delivering antigens adjuvants cells, improving ОС results. show prominent potential EC despite that this context remains understudied compared other types Conclusion Nanoparticles can carry both conventional drugs protein- nucleic acid-based However, only few nanoparticle-based treatments have been approved use. field is making significant progress toward more effective widely available treatments.

Язык: Английский

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Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Diabetes mellitus (DM) is a chronic metabolic disorder marked by sustained hyperglycemia. These disturbances contribute to extensive damage across various tissues and organs, giving rise severe complications such as vision loss, kidney failure, amputations, higher morbidity mortality rates. Furthermore, DM imposes substantial economic emotional burden on patients, families, healthcare systems. Mitophagy, selective process that targets the clearance of damaged or dysfunctional mitochondria, pivotal for sustaining cellular homeostasis through mitochondrial turnover recycling. Emerging evidence indicates mitophagy acts key pathogenic driver in pathogenesis its associated complications. Natural small molecules are particularly attractive this regard, offering advantages low toxicity, favorable pharmacokinetic profiles, excellent biocompatibility, broad range biochemical activities. This review systematically evaluates mechanistic roles natural molecules-including ginsenosides, resveratrol, berberine-in enhancing restoring via activation core signaling pathways (e.g., PINK1/Parkin, BNIP3/NIX, FUNDC1). collectively ameliorate pathological hallmarks DM, oxidative stress, inflammation, insulin resistance. integration nanotechnology with these compounds optimizes their bioavailability tissue-specific targeting, thereby establishing transformative therapeutic platform management. Current demonstrates modulation not only offers novel strategies but also advances foundation future drug development targeting disorders.

Язык: Английский

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Smart on-demand drug release strategies for cancer combination therapy

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113782 - 113782

Опубликована: Апрель 1, 2025

Язык: Английский

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